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ALOX5 (arachidonate 5-lipoxygenase)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
240
Gene nameGene Name - the full gene name approved by the HGNC.
Arachidonate 5-lipoxygenase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ALOX5
SynonymsGene synonyms aliases
5-LO, 5-LOX, 5LPG, LOG5
ChromosomeChromosome number
10
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q11.21
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachid
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT736469 hsa-miR-125a-3p RNA-seq, Immunofluorescence 33205517
MIRT736470 hsa-let-7e-3p RNA-seq, Immunofluorescence 33205517
MIRT736469 hsa-miR-125a-3p RNA-seq, Immunofluorescence 33205517
MIRT778919 hsa-miR-186 CLIP-seq
MIRT778920 hsa-miR-3688-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
EGR1 Activation 9062372
EGR1 Repression 15517885
EGR1 Unknown 10436859
HDAC2 Activation 21883892
HDAC3 Activation 21883892
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0001937 Process Negative regulation of endothelial cell proliferation ISS
GO:0002232 Process Leukocyte chemotaxis involved in inflammatory response IMP 17114001
GO:0002523 Process Leukocyte migration involved in inflammatory response ISS
GO:0002540 Process Leukotriene production involved in inflammatory response IEA
GO:0004051 Function Arachidonate 5-lipoxygenase activity IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P09917
Protein name Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
Protein function Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis o
PDB 3O8Y , 3V92 , 3V98 , 3V99 , 6N2W , 6NCF , 7TTJ , 7TTK , 7TTL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01477 PLAT
4 → 113
PLAT/LH2 domain
 Domain
PF00305 Lipoxygenase
216 → 662
Lipoxygenase
 Domain
Sequence
Sequence length 674
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Arachidonic acid metabolism
Metabolic pathways
Efferocytosis
Fc epsilon RI signaling pathway
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis 		  Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Interleukin-18 signaling
Biosynthesis of D-series resolvins
Biosynthesis of maresins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-3-derived protectins and resolvins
Biosynthesis of DPAn-3-derived maresins
Biosynthesis of DPAn-3-derived 13-series resolvins
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 30258081
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283
Carcinoma Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 30258081
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 14569062, 30258081, 18927292, 30258081, 18927292, 14569062
Unknown
Disease name Disease term dbSNP ID References
Adenoma Adenoma, Adenoma, Basal Cell, Follicular adenoma, Adenoma, Microcystic, Adenoma, Monomorphic, Adenoma, Trabecular 18927292
Atherosclerosis Atherosclerosis rs699947, rs59439148 16698924
Cerebral infraction Infarction, Middle Cerebral Artery 19309543
Cerebral thrombosis Middle Cerebral Artery Thrombosis 19309543

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