BRD1 (bromodomain containing 1)

Gene

• Entrez ID: 23774
• Gene name: Bromodomain containing 1
• Gene symbol: BRD1
• Synonyms: BRL, BRPF1, BRPF2
• Chromosome: 22
• Chromosome location: 22q13.33
• Summary: This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021155	hsa-miR-186-5p	Sequencing	20371350
MIRT024192	hsa-miR-221-3p	Sequencing	20371350
MIRT046561	hsa-let-7g-5p	CLASH	23622248
MIRT041191	hsa-miR-497-5p	CLASH	23622248
MIRT040831	hsa-miR-18a-3p	CLASH	23622248
MIRT824152	hsa-miR-1273f	CLIP-seq
MIRT824153	hsa-miR-137	CLIP-seq
MIRT824154	hsa-miR-150	CLIP-seq
MIRT824155	hsa-miR-1972	CLIP-seq
MIRT824156	hsa-miR-2052	CLIP-seq
MIRT824157	hsa-miR-21	CLIP-seq
MIRT824158	hsa-miR-300	CLIP-seq
MIRT824159	hsa-miR-3163	CLIP-seq
MIRT824160	hsa-miR-329	CLIP-seq
MIRT824161	hsa-miR-338-5p	CLIP-seq
MIRT824162	hsa-miR-362-3p	CLIP-seq
MIRT824163	hsa-miR-3713	CLIP-seq
MIRT824164	hsa-miR-381	CLIP-seq
MIRT824165	hsa-miR-3941	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT824167	hsa-miR-4255	CLIP-seq
MIRT824168	hsa-miR-4452	CLIP-seq
MIRT824169	hsa-miR-4480	CLIP-seq
MIRT824170	hsa-miR-455-5p	CLIP-seq
MIRT824171	hsa-miR-4666-3p	CLIP-seq
MIRT824172	hsa-miR-4668-3p	CLIP-seq
MIRT824173	hsa-miR-4729	CLIP-seq
MIRT824174	hsa-miR-4789-5p	CLIP-seq
MIRT824175	hsa-miR-520g	CLIP-seq
MIRT824176	hsa-miR-520h	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT824178	hsa-miR-550a	CLIP-seq
MIRT824179	hsa-miR-561	CLIP-seq
MIRT824180	hsa-miR-568	CLIP-seq
MIRT824181	hsa-miR-586	CLIP-seq
MIRT824182	hsa-miR-590-5p	CLIP-seq
MIRT824183	hsa-miR-603	CLIP-seq
MIRT824184	hsa-miR-767-3p	CLIP-seq
MIRT824155	hsa-miR-1972	CLIP-seq
MIRT824158	hsa-miR-300	CLIP-seq
MIRT824160	hsa-miR-329	CLIP-seq
MIRT824162	hsa-miR-362-3p	CLIP-seq
MIRT824164	hsa-miR-381	CLIP-seq
MIRT824165	hsa-miR-3941	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT824171	hsa-miR-4666-3p	CLIP-seq
MIRT824173	hsa-miR-4729	CLIP-seq
MIRT824174	hsa-miR-4789-5p	CLIP-seq
MIRT824175	hsa-miR-520g	CLIP-seq
MIRT824176	hsa-miR-520h	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT824181	hsa-miR-586	CLIP-seq
MIRT824183	hsa-miR-603	CLIP-seq
MIRT2182303	hsa-miR-122	CLIP-seq
MIRT824154	hsa-miR-150	CLIP-seq
MIRT824157	hsa-miR-21	CLIP-seq
MIRT824159	hsa-miR-3163	CLIP-seq
MIRT2182304	hsa-miR-340	CLIP-seq
MIRT2182305	hsa-miR-3659	CLIP-seq
MIRT2182306	hsa-miR-3667-5p	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT2182307	hsa-miR-4289	CLIP-seq
MIRT824169	hsa-miR-4480	CLIP-seq
MIRT824172	hsa-miR-4668-3p	CLIP-seq
MIRT824175	hsa-miR-520g	CLIP-seq
MIRT824176	hsa-miR-520h	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT824182	hsa-miR-590-5p	CLIP-seq
MIRT824184	hsa-miR-767-3p	CLIP-seq
MIRT824152	hsa-miR-1273f	CLIP-seq
MIRT2486001	hsa-miR-3124-3p	CLIP-seq
MIRT2486002	hsa-miR-3692	CLIP-seq
MIRT2486003	hsa-miR-384	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT2486004	hsa-miR-4643	CLIP-seq
MIRT2486005	hsa-miR-466	CLIP-seq
MIRT2486006	hsa-miR-4672	CLIP-seq
MIRT2486007	hsa-miR-4698	CLIP-seq
MIRT2486008	hsa-miR-4713-5p	CLIP-seq
MIRT2486009	hsa-miR-4789-3p	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT2486010	hsa-miR-616	CLIP-seq
MIRT824152	hsa-miR-1273f	CLIP-seq
MIRT2676034	hsa-miR-1587	CLIP-seq
MIRT2486001	hsa-miR-3124-3p	CLIP-seq
MIRT2486002	hsa-miR-3692	CLIP-seq
MIRT2676035	hsa-miR-378g	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT2676036	hsa-miR-4286	CLIP-seq
MIRT2676037	hsa-miR-4492	CLIP-seq
MIRT2676038	hsa-miR-4498	CLIP-seq
MIRT2676039	hsa-miR-4656	CLIP-seq
MIRT2486006	hsa-miR-4672	CLIP-seq
MIRT2676040	hsa-miR-4675	CLIP-seq
MIRT2486007	hsa-miR-4698	CLIP-seq
MIRT2486008	hsa-miR-4713-5p	CLIP-seq
MIRT2676041	hsa-miR-4741	CLIP-seq
MIRT2676042	hsa-miR-521	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT2676043	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	10602503, 21880731
GO:0005634	Component	Nucleus	IMP	21753189
GO:0005634	Component	Nucleus	TAS	10602503
GO:0005694	Component	Chromosome	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0030425	Component	Dendrite	IEA
GO:0035902	Process	Response to immobilization stress	IEA
GO:0036409	Component	Histone H3-K14 acetyltransferase complex	IDA	21753189
GO:0042393	Function	Histone binding	IBA	21873635
GO:0042393	Function	Histone binding	IDA	21880731
GO:0043204	Component	Perikaryon	IEA
GO:0043249	Process	Erythrocyte maturation	IEA
GO:0043966	Process	Histone H3 acetylation	IDA	16387653
GO:0043972	Process	Histone H3-K23 acetylation	IEA
GO:0043994	Function	Histone acetyltransferase activity (H3-K23 specific)	IBA	21873635
GO:0044154	Process	Histone H3-K14 acetylation	IBA	21873635
GO:0044154	Process	Histone H3-K14 acetylation	ISS
GO:0045648	Process	Positive regulation of erythrocyte differentiation	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051602	Process	Response to electrical stimulus	IEA
GO:0070776	Component	MOZ/MORF histone acetyltransferase complex	IBA	21873635
GO:0070776	Component	MOZ/MORF histone acetyltransferase complex	IDA	16387653

Other IDs

• MIM: 604589
• HGNC: 1102
• e!Ensembl: ENSG00000100425

Protein

• UniProt ID: O95696
• Protein name: Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2)
• Protein function: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by di
• PDB: 2KU3, 2L43, 2LQ6, 3LYI, 3RCW, 4Z02, 5AME, 5AMF, 5FG6, 5GK9, 5N49, 5PNX, 5PNY, 5PNZ, 5PO0, 5PO1, 5PO2, 5PO3, 5PO4, 5PO5, 5PO6, 5PO7, 5PO8, 5PO9, 5POA, 5POB, 5POC, 5POD, 5POE, 5POF, 5POG, 5POH, 5POI, 5POJ, 5POK, 5POL, 5POM, 5PON, 5POO, 5POP, 5POQ, 5POR, 5POS, 5POT, 5POU, 5POV, 5POW, 5POX, 5POY, 5POZ, 5PP0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10513	EPL1	47 → 196	Enhancer of polycomb-like	Family
  PF13831	PHD_2	228 → 262		Family
  PF13832	zf-HC5HC2H_2	269 → 388		Domain
  PF00439	Bromodomain	571 → 654	Bromodomain	Domain
  PF00855	PWWP	927 → 1044	PWWP domain	Domain

• Sequence:

  MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEII
  LEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEP
  KVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPA
  VSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLA
  VHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPE
  VGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGL
  YMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTV
  RSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPPQRLNRIANQVAIQRKKQFVERAHSYW
  LLKRLSRNGAPLLRRLQSSLQSQRSSQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIE
  LLRKREKLKREQVKVEQVAMELRLTPLTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYL
  DHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGG
  VVLRQARREVDSIGLEEASGMHLPERPAAAPRRPFSWEDVDRLLDPANRAHLGLEEQLRE
  LLDMLDLTCAMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEEDGAALG
  PEAGEEVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGL
  GRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENGN
  YAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHN
  GVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETIDKLKM
  MEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID

• Sequence length: 1058

Pathways

Reactome:

HATs acetylate histones
Regulation of TP53 Activity through Acetylation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Adenocarcinoma	Adenoid Cystic Carcinoma	rs121913530, rs886039394, rs121913474	23685749
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19908236, 23894747, 16924267, 19693800, 19763615, 22341945

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		19763615, 22341945, 16924267, 19693800