Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23659 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Phospholipase A2 group XV |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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PLA2G15 |
SynonymsGene synonyms aliases
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ACS, GXVPLA2, LLPL, LPLA2, LYPLA3 |
ChromosomeChromosome number
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16 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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16q22.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is presen |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q8NCC3 |
Protein name |
Lysosomal phospholipase A and acyltransferase (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) (Phospholipase A2 group XV |
Protein function |
Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:10092508, P |
PDB |
4X90
,
4X91
,
4X92
,
4X93
,
4X94
,
4X95
,
4X97
,
6MTW
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02450 |
LCAT |
72 → 318 |
Lecithin:cholesterol acyltransferase |
Family |
PF02450 |
LCAT |
309 → 399 |
Lecithin:cholesterol acyltransferase |
Family |
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Sequence |
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Sequence length |
412 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
29483656 |
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