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SLC7A11 (solute carrier family 7 member 11)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23657
Gene nameGene Name - the full gene name approved by the HGNC.
Solute carrier family 7 member 11
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SLC7A11
SynonymsGene synonyms aliases
CCBR1, xCT
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q28.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamat
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003333 Process Amino acid transmembrane transport IBA 21873635
GO:0005515 Function Protein binding IPI 21397861, 32296183
GO:0005791 Component Rough endoplasmic reticulum IEA
GO:0005856 Component Cytoskeleton IEA
GO:0005886 Component Plasma membrane TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9UPY5
Protein name Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
Protein function Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:11133847, PubMed:11417227, PubMed:14722095, PubMed:15
PDB 7CCS , 7EPZ , 7P9U , 7P9V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2
44 470
Amino acid permease
Family
Sequence
Sequence length 501
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Ferroptosis   Basigin interactions
Amino acid transport across the plasma membrane
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174

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