HEBP2 (heme binding protein 2)

Gene

• Entrez ID: 23593
• Gene name: Heme binding protein 2
• Gene symbol: HEBP2
• Synonyms: C6ORF34B, C6orf34, PP23, SOUL
• Chromosome: 6
• Chromosome location: 6q24.1
• Summary: The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane per

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002643	hsa-miR-124-3p	Microarray	15685193
MIRT002643	hsa-miR-124-3p	Microarray;Other	15685193
MIRT715677	hsa-miR-543	HITS-CLIP	19536157
MIRT715676	hsa-miR-15a-3p	HITS-CLIP	19536157
MIRT715674	hsa-miR-1972	HITS-CLIP	19536157
MIRT715675	hsa-miR-622	HITS-CLIP	19536157
MIRT715673	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT715672	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT715671	hsa-miR-5189-3p	HITS-CLIP	19536157
MIRT642179	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT642178	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT642177	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT642176	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT642175	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT642174	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT642173	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT642172	hsa-miR-612	HITS-CLIP	23824327
MIRT642171	hsa-miR-6860	HITS-CLIP	23824327
MIRT642170	hsa-miR-4486	HITS-CLIP	23824327
MIRT642168	hsa-miR-1260a	HITS-CLIP	23824327
MIRT642169	hsa-miR-4314	HITS-CLIP	23824327
MIRT607500	hsa-miR-500b-3p	HITS-CLIP	24906430
MIRT607499	hsa-miR-5693	HITS-CLIP	24906430
MIRT607498	hsa-miR-6773-3p	HITS-CLIP	24906430
MIRT607497	hsa-miR-215-3p	HITS-CLIP	24906430
MIRT607496	hsa-miR-383-5p	HITS-CLIP	24906430
MIRT607495	hsa-miR-4772-5p	HITS-CLIP	24906430
MIRT607494	hsa-miR-6499-3p	HITS-CLIP	24906430
MIRT607493	hsa-miR-3194-3p	HITS-CLIP	24906430
MIRT607492	hsa-miR-3135b	HITS-CLIP	24906430
MIRT607491	hsa-miR-504-3p	HITS-CLIP	24906430
MIRT607490	hsa-miR-122-5p	HITS-CLIP	24906430
MIRT607489	hsa-miR-3622b-5p	HITS-CLIP	24906430
MIRT607488	hsa-miR-3652	HITS-CLIP	24906430
MIRT607487	hsa-miR-4430	HITS-CLIP	24906430
MIRT607486	hsa-miR-6879-3p	HITS-CLIP	24906430
MIRT607485	hsa-miR-143-5p	HITS-CLIP	24906430
MIRT607484	hsa-miR-5691	HITS-CLIP	24906430
MIRT607483	hsa-miR-6805-3p	HITS-CLIP	24906430
MIRT607482	hsa-miR-5698	HITS-CLIP	24906430
MIRT715677	hsa-miR-543	HITS-CLIP	19536157
MIRT715676	hsa-miR-15a-3p	HITS-CLIP	19536157
MIRT715674	hsa-miR-1972	HITS-CLIP	19536157
MIRT715675	hsa-miR-622	HITS-CLIP	19536157
MIRT715673	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT715672	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT715671	hsa-miR-5189-3p	HITS-CLIP	19536157
MIRT642179	hsa-miR-6819-3p	HITS-CLIP	23824327
MIRT642178	hsa-miR-6877-3p	HITS-CLIP	23824327
MIRT642177	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT642176	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT642175	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT642174	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT642173	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT642172	hsa-miR-612	HITS-CLIP	23824327
MIRT642171	hsa-miR-6860	HITS-CLIP	23824327
MIRT642170	hsa-miR-4486	HITS-CLIP	23824327
MIRT642168	hsa-miR-1260a	HITS-CLIP	23824327
MIRT642169	hsa-miR-4314	HITS-CLIP	23824327
MIRT1043343	hsa-miR-1252	CLIP-seq
MIRT1043344	hsa-miR-2052	CLIP-seq
MIRT1043345	hsa-miR-297	CLIP-seq
MIRT1043346	hsa-miR-3173-3p	CLIP-seq
MIRT1043347	hsa-miR-3668	CLIP-seq
MIRT1043348	hsa-miR-3935	CLIP-seq
MIRT1043349	hsa-miR-4307	CLIP-seq
MIRT1043350	hsa-miR-4779	CLIP-seq
MIRT1043351	hsa-miR-4796-5p	CLIP-seq
MIRT1043352	hsa-miR-513a-3p	CLIP-seq
MIRT1043353	hsa-miR-567	CLIP-seq
MIRT1043354	hsa-miR-577	CLIP-seq
MIRT2009285	hsa-miR-1278	CLIP-seq
MIRT2241712	hsa-miR-3117-5p	CLIP-seq
MIRT2241713	hsa-miR-4704-5p	CLIP-seq
MIRT2451079	hsa-miR-548u	CLIP-seq
MIRT2451079	hsa-miR-548u	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21639858, 25416956, 27784779, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	17098234
GO:0005739	Component	Mitochondrion	IDA	17098234
GO:0010917	Process	Negative regulation of mitochondrial membrane potential	IMP	17098234
GO:0010940	Process	Positive regulation of necrotic cell death	IMP	17098234
GO:0020037	Function	Heme binding	IBA	21873635
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0035794	Process	Positive regulation of mitochondrial membrane permeability	IMP	17098234
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1901031	Process	Regulation of response to reactive oxygen species	IMP	17098234

Other IDs

• MIM: 605825
• HGNC: 15716
• e!Ensembl: ENSG00000051620

Protein

• UniProt ID: Q9Y5Z4
• Protein name: Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL)
• Protein function: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.
• PDB: 3R85, 3R8J, 3R8K, 4AYZ, 4B0Y, 5GQQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04832	SOUL	20 → 195	SOUL heme-binding protein	Family

• Sequence:

  MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVSTSVESMDWDS
  AIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSESTITISLYIPSEQQFDPP
  RPLESDVFIEDRAEMTVFVRSFDGFSSAQKNQEQLLTLASILREDGKVFDEKVYYTAGYN
  SPVKLLNRNNEVWLIQKNEPTKENE

• Sequence length: 205

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver neoplasms	Liver neoplasms		25058030
Liver cancer	Malignant neoplasm of liver		25058030