Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
2355 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
FOS like 2, AP-1 transcription factor subunit |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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FOSL2 |
SynonymsGene synonyms aliases
|
ACED, FRA2 |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2p23.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have bee |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000977 |
Function |
RNA polymerase II transcription regulatory region sequence-specific DNA binding |
IDA |
13679379 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
|
GO:0001228 |
Function |
DNA-binding transcription activator activity, RNA polymerase II-specific |
IDA |
13679379 |
GO:0003334 |
Process |
Keratinocyte development |
IEA |
|
GO:0003682 |
Function |
Chromatin binding |
IEA |
|
GO:0003700 |
Function |
DNA-binding transcription factor activity |
TAS |
8954781 |
GO:0005515 |
Function |
Protein binding |
IPI |
19321746, 20102225, 25416956, 25609649, 26496610, 27107012, 28514442, 31515488, 32296183, 32814053, 32911434 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0008219 |
Process |
Cell death |
TAS |
8954781 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
13679379 |
GO:0048146 |
Process |
Positive regulation of fibroblast proliferation |
IEA |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P15408 |
Protein name |
Fos-related antigen 2 (FRA-2) |
Protein function |
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). {ECO:0000250|UniProtKB:P47930, ECO:0000250|UniP |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00170 |
bZIP_1 |
122 → 183 |
bZIP transcription factor |
Coiled-coil |
|
Sequence |
MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSGSAFIPTINAITTSQDL QWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRRRRDEQLS PEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKL EFMLVAHGPVCKISPEERRSPPAPGLQPMRSGGGSVGAVVVKQEPLEEDSPSSSSAGLDK AQRSVIKPISIAGGFYGEEPLHTPIVVTSTPAVTPGTSNLVFTYPSVLEQESPASPSESC SKAHRRSSSSGDQSSDSLNSPTLLAL
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|
Sequence length |
326 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Arthritis |
Juvenile arthritis |
rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 |
19565504 |
Glioblastoma |
Glioblastoma, Glioblastoma Multiforme |
rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 |
23582323 |
Inflammatory bowel disease |
Inflammatory Bowel Diseases |
rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 |
26192919 |
Lung cancer |
Malignant neoplasm of lung |
rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 |
27935865 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Eczema |
Eczema |
|
30595370 |
Giant cell glioblastoma |
Giant Cell Glioblastoma |
|
23582323 |
Juvenile arthritis |
Juvenile psoriatic arthritis |
|
19565504 |
Lung neoplasms |
Lung Neoplasms |
|
27935865 |
Seronegative polyarthritis |
Polyarthritis, Juvenile, Rheumatoid Factor Negative |
|
19565504 |
Polyarthritis, rheumatoid factor positive |
Polyarthritis, Juvenile, Rheumatoid Factor Positive |
|
19565504 |
Still disease |
Juvenile-Onset Still Disease |
|
19565504 |
|