CLCF1 (cardiotrophin like cytokine factor 1)

Gene

• Entrez ID: 23529
• Gene name: Cardiotrophin like cytokine factor 1
• Gene symbol: CLCF1
• Synonyms: BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6
• Chromosome: 11
• Chromosome location: 11q13.2
• Summary: This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic facto

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440940	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440940	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT894535	hsa-miR-1293	CLIP-seq
MIRT894536	hsa-miR-3151	CLIP-seq
MIRT894537	hsa-miR-3158-3p	CLIP-seq
MIRT894538	hsa-miR-412	CLIP-seq
MIRT894539	hsa-miR-4481	CLIP-seq
MIRT894540	hsa-miR-4483	CLIP-seq
MIRT894541	hsa-miR-4693-3p	CLIP-seq
MIRT894542	hsa-miR-4745-5p	CLIP-seq
MIRT894543	hsa-miR-4758-5p	CLIP-seq
MIRT894544	hsa-miR-486-3p	CLIP-seq
MIRT894545	hsa-miR-603	CLIP-seq
MIRT1965277	hsa-miR-1207-5p	CLIP-seq
MIRT1965278	hsa-miR-1236	CLIP-seq
MIRT894535	hsa-miR-1293	CLIP-seq
MIRT1965279	hsa-miR-1914	CLIP-seq
MIRT1965280	hsa-miR-2053	CLIP-seq
MIRT1965281	hsa-miR-218	CLIP-seq
MIRT1965282	hsa-miR-299-5p	CLIP-seq
MIRT894536	hsa-miR-3151	CLIP-seq
MIRT1965283	hsa-miR-3160-5p	CLIP-seq
MIRT1965284	hsa-miR-3166	CLIP-seq
MIRT1965285	hsa-miR-3918	CLIP-seq
MIRT1965286	hsa-miR-4283	CLIP-seq
MIRT1965287	hsa-miR-4436b-3p	CLIP-seq
MIRT894539	hsa-miR-4481	CLIP-seq
MIRT894540	hsa-miR-4483	CLIP-seq
MIRT1965288	hsa-miR-4489	CLIP-seq
MIRT1965289	hsa-miR-4492	CLIP-seq
MIRT1965290	hsa-miR-4498	CLIP-seq
MIRT1965291	hsa-miR-4505	CLIP-seq
MIRT1965292	hsa-miR-4512	CLIP-seq
MIRT1965293	hsa-miR-4731-5p	CLIP-seq
MIRT894542	hsa-miR-4745-5p	CLIP-seq
MIRT1965294	hsa-miR-4753-3p	CLIP-seq
MIRT1965295	hsa-miR-4761-3p	CLIP-seq
MIRT1965296	hsa-miR-4763-3p	CLIP-seq
MIRT1965297	hsa-miR-4768-5p	CLIP-seq
MIRT1965298	hsa-miR-4771	CLIP-seq
MIRT894544	hsa-miR-486-3p	CLIP-seq
MIRT1965299	hsa-miR-569	CLIP-seq
MIRT894545	hsa-miR-603	CLIP-seq
MIRT1965300	hsa-miR-636	CLIP-seq
MIRT1965301	hsa-miR-637	CLIP-seq
MIRT1965302	hsa-miR-762	CLIP-seq
MIRT1965277	hsa-miR-1207-5p	CLIP-seq
MIRT894535	hsa-miR-1293	CLIP-seq
MIRT2201219	hsa-miR-2110	CLIP-seq
MIRT2201220	hsa-miR-22	CLIP-seq
MIRT2201221	hsa-miR-3150a-3p	CLIP-seq
MIRT894536	hsa-miR-3151	CLIP-seq
MIRT894537	hsa-miR-3158-3p	CLIP-seq
MIRT2201222	hsa-miR-3175	CLIP-seq
MIRT2201223	hsa-miR-3189-3p	CLIP-seq
MIRT1965285	hsa-miR-3918	CLIP-seq
MIRT894538	hsa-miR-412	CLIP-seq
MIRT1965286	hsa-miR-4283	CLIP-seq
MIRT2201224	hsa-miR-4300	CLIP-seq
MIRT894540	hsa-miR-4483	CLIP-seq
MIRT1965288	hsa-miR-4489	CLIP-seq
MIRT1965289	hsa-miR-4492	CLIP-seq
MIRT1965290	hsa-miR-4498	CLIP-seq
MIRT1965291	hsa-miR-4505	CLIP-seq
MIRT1965292	hsa-miR-4512	CLIP-seq
MIRT2201225	hsa-miR-4715-3p	CLIP-seq
MIRT1965293	hsa-miR-4731-5p	CLIP-seq
MIRT1965296	hsa-miR-4763-3p	CLIP-seq
MIRT894544	hsa-miR-486-3p	CLIP-seq
MIRT2201226	hsa-miR-548an	CLIP-seq
MIRT2201227	hsa-miR-558	CLIP-seq
MIRT1965301	hsa-miR-637	CLIP-seq
MIRT1965302	hsa-miR-762	CLIP-seq
MIRT2201228	hsa-miR-920	CLIP-seq
MIRT2201229	hsa-miR-939	CLIP-seq
MIRT894535	hsa-miR-1293	CLIP-seq
MIRT894536	hsa-miR-3151	CLIP-seq
MIRT1965286	hsa-miR-4283	CLIP-seq
MIRT894540	hsa-miR-4483	CLIP-seq
MIRT1965288	hsa-miR-4489	CLIP-seq
MIRT894535	hsa-miR-1293	CLIP-seq
MIRT894540	hsa-miR-4483	CLIP-seq
MIRT1965291	hsa-miR-4505	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002639	Process	Positive regulation of immunoglobulin production	ISS
GO:0005102	Function	Signaling receptor binding	IPI	15272019
GO:0005125	Function	Cytokine activity	IDA	10966616
GO:0005125	Function	Cytokine activity	NAS	10500198
GO:0005127	Function	Ciliary neurotrophic factor receptor binding	IDA	11285233
GO:0005127	Function	Ciliary neurotrophic factor receptor binding	IDA	10966616
GO:0005515	Function	Protein binding	IPI	10966616, 26858303, 29507344
GO:0005576	Component	Extracellular region	IBA	21873635
GO:0005576	Component	Extracellular region	IDA	10966616
GO:0005576	Component	Extracellular region	NAS	10448081
GO:0005576	Component	Extracellular region	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IBA	21873635
GO:0007166	Process	Cell surface receptor signaling pathway	ISS
GO:0007259	Process	Receptor signaling pathway via JAK-STAT	IBA	21873635
GO:0007259	Process	Receptor signaling pathway via JAK-STAT	ISS
GO:0008083	Function	Growth factor activity	TAS	14632778
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	10966616, 11285233
GO:0019221	Process	Cytokine-mediated signaling pathway	NAS	10500198
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0030183	Process	B cell differentiation	ISS
GO:0030890	Process	Positive regulation of B cell proliferation	IBA	21873635
GO:0030890	Process	Positive regulation of B cell proliferation	ISS
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IBA	21873635
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	10966616, 11285233
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	TAS	14632778
GO:0043524	Process	Negative regulation of neuron apoptotic process	IDA	10966616, 11285233
GO:0048295	Process	Positive regulation of isotype switching to IgE isotypes	ISS
GO:0048711	Process	Positive regulation of astrocyte differentiation	ISS
GO:0097058	Component	CRLF-CLCF1 complex	IBA	21873635
GO:0097058	Component	CRLF-CLCF1 complex	IDA	10966616
GO:0097059	Component	CNTFR-CLCF1 complex	IBA	21873635
GO:0097059	Component	CNTFR-CLCF1 complex	IDA	11285233

Other IDs

• MIM: 607672
• HGNC: 17412
• e!Ensembl: ENSG00000175505

Protein

• UniProt ID: Q9UBD9
• Protein name: Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)
• Protein function: In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor. {ECO:0000269|PubMed:10448081, ECO:000026
• PDB: 8D7H, 8D7R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06875	PRF	40 → 213	Plethodontid receptivity factor PRF	Domain

• Sequence:

  MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTYDLTRYLEHQLRSLAGT
  YLNYLGPPFNEPDFNPPRLGAETLPRATVDLEVWRSLNDKLRLTQNYEAYSHLLCYLRGL
  NRQAATAELRRSLAHFCTSLQGLLGSIAGVMAALGYPLPQPLPGTEPTWTPGPAHSDFLQ
  KMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAAAVTLHLGAHGF

• Sequence length: 225

Pathways

KEGG:

Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway

Reactome:

IL-6-type cytokine receptor ligand interactions

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cold-induced sweating syndrome	COLD-INDUCED SWEATING SYNDROME 1, COLD-INDUCED SWEATING SYNDROME 2, Cold-induced sweating syndrome	rs104894198, rs104894203, rs761746361, rs137853143, rs137853144, rs2145329741, rs137853145, rs367543004, rs137853929, rs137853932, rs137853934, rs137853935, rs768727082, rs137853928, rs879255557, rs879255558, rs780705654, rs879255556, rs1555758035, rs1600650861	1678282, 20400119, 16782820
Crisponi syndrome	Crisponi syndrome	rs1600651228	1678282, 20400119
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085

Unknown
Disease name	Disease term	dbSNP ID	References
Cubitus valgus	Acquired cubitus valgus
Clinodactyly	Clinodactyly of fingers, Clinodactyly
Facial paralysis	Facial paralysis
High palate	Byzanthine arch palate
Hypohidrosis	Hypohidrosis
Impaired cognition	Impaired cognition
Micrognathism	Micrognathism
Microstomia	Microstomia
Sensorimotor neuropathy	Sensorimotor neuropathy
Syndactyly of the toes	2-3 toe syndactyly
Thoracolumbar scoliosis	Thoracolumbar scoliosis