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DAAM2 (dishevelled associated activator of morphogenesis 2)

Gene

Dishevelled associated activator of morphogenesis 2

DAAM2

NPHS24, dJ90A20A.1

6

6p21.2

Show/Hide all(258)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031230	hsa-miR-19b-3p	Sequencing	20371350
MIRT031355	hsa-miR-18a-5p	Sequencing	20371350
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT640334	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT640333	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT640332	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT640331	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT640330	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT640329	hsa-miR-7112-3p	HITS-CLIP	23824327
MIRT640328	hsa-miR-4711-5p	HITS-CLIP	23824327
MIRT640327	hsa-miR-3136-5p	HITS-CLIP	23824327
MIRT640326	hsa-miR-4439	HITS-CLIP	23824327
MIRT640325	hsa-miR-943	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT640334	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT640333	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT640332	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT640331	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT640330	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT640329	hsa-miR-7112-3p	HITS-CLIP	23824327
MIRT640328	hsa-miR-4711-5p	HITS-CLIP	23824327
MIRT640327	hsa-miR-3136-5p	HITS-CLIP	23824327
MIRT640326	hsa-miR-4439	HITS-CLIP	23824327
MIRT640325	hsa-miR-943	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT609347	hsa-miR-8485	HITS-CLIP	23824327
MIRT609346	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT609345	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT609344	hsa-miR-589-3p	HITS-CLIP	23824327
MIRT609343	hsa-miR-7108-3p	HITS-CLIP	23824327
MIRT609342	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT922481	hsa-miR-1207-3p	CLIP-seq
MIRT922482	hsa-miR-1224-3p	CLIP-seq
MIRT922483	hsa-miR-1260	CLIP-seq
MIRT922484	hsa-miR-1260b	CLIP-seq
MIRT922485	hsa-miR-1266	CLIP-seq
MIRT922486	hsa-miR-1273f	CLIP-seq
MIRT922487	hsa-miR-1280	CLIP-seq
MIRT922488	hsa-miR-1299	CLIP-seq
MIRT922489	hsa-miR-138	CLIP-seq
MIRT922490	hsa-miR-143	CLIP-seq
MIRT922491	hsa-miR-146a	CLIP-seq
MIRT922492	hsa-miR-146b-5p	CLIP-seq
MIRT922493	hsa-miR-1470	CLIP-seq
MIRT922494	hsa-miR-1827	CLIP-seq
MIRT922495	hsa-miR-197	CLIP-seq
MIRT922496	hsa-miR-198	CLIP-seq
MIRT922497	hsa-miR-2355-5p	CLIP-seq
MIRT922498	hsa-miR-3144-5p	CLIP-seq
MIRT922499	hsa-miR-3191	CLIP-seq
MIRT922500	hsa-miR-3202	CLIP-seq
MIRT922501	hsa-miR-3622a-3p	CLIP-seq
MIRT922502	hsa-miR-3622b-3p	CLIP-seq
MIRT922503	hsa-miR-3664-3p	CLIP-seq
MIRT922504	hsa-miR-3914	CLIP-seq
MIRT922505	hsa-miR-3934	CLIP-seq
MIRT922506	hsa-miR-4254	CLIP-seq
MIRT922507	hsa-miR-4299	CLIP-seq
MIRT922508	hsa-miR-4323	CLIP-seq
MIRT922509	hsa-miR-4434	CLIP-seq
MIRT922510	hsa-miR-4435	CLIP-seq
MIRT922511	hsa-miR-4516	CLIP-seq
MIRT922512	hsa-miR-4518	CLIP-seq
MIRT922513	hsa-miR-4531	CLIP-seq
MIRT922514	hsa-miR-4533	CLIP-seq
MIRT922515	hsa-miR-4652-5p	CLIP-seq
MIRT922516	hsa-miR-4667-3p	CLIP-seq
MIRT922517	hsa-miR-4690-3p	CLIP-seq
MIRT922518	hsa-miR-4691-5p	CLIP-seq
MIRT922519	hsa-miR-4694-3p	CLIP-seq
MIRT922520	hsa-miR-4698	CLIP-seq
MIRT922521	hsa-miR-4708-5p	CLIP-seq
MIRT922522	hsa-miR-4710	CLIP-seq
MIRT922523	hsa-miR-4768-3p	CLIP-seq
MIRT922524	hsa-miR-4770	CLIP-seq
MIRT922525	hsa-miR-4773	CLIP-seq
MIRT922526	hsa-miR-4777-5p	CLIP-seq
MIRT922527	hsa-miR-4792	CLIP-seq
MIRT922528	hsa-miR-512-5p	CLIP-seq
MIRT922529	hsa-miR-513b	CLIP-seq
MIRT922530	hsa-miR-532-3p	CLIP-seq
MIRT922531	hsa-miR-589	CLIP-seq
MIRT922532	hsa-miR-619	CLIP-seq
MIRT922533	hsa-miR-665	CLIP-seq
MIRT922534	hsa-miR-873	CLIP-seq
MIRT922535	hsa-miR-875-3p	CLIP-seq
MIRT922536	hsa-miR-2682	CLIP-seq
MIRT922537	hsa-miR-298	CLIP-seq
MIRT922538	hsa-miR-3714	CLIP-seq
MIRT922539	hsa-miR-449c	CLIP-seq
MIRT922540	hsa-miR-4662a-3p	CLIP-seq
MIRT922541	hsa-miR-488	CLIP-seq
MIRT922542	hsa-miR-548an	CLIP-seq
MIRT922543	hsa-miR-940	CLIP-seq
MIRT1547843	hsa-miR-1252	CLIP-seq
MIRT1922675	hsa-miR-3156-3p	CLIP-seq
MIRT922501	hsa-miR-3622a-3p	CLIP-seq
MIRT922502	hsa-miR-3622b-3p	CLIP-seq
MIRT922506	hsa-miR-4254	CLIP-seq
MIRT1922676	hsa-miR-4279	CLIP-seq
MIRT1922677	hsa-miR-4301	CLIP-seq
MIRT922509	hsa-miR-4434	CLIP-seq
MIRT922511	hsa-miR-4516	CLIP-seq
MIRT922513	hsa-miR-4531	CLIP-seq
MIRT922530	hsa-miR-532-3p	CLIP-seq
MIRT922532	hsa-miR-619	CLIP-seq
MIRT922518	hsa-miR-4691-5p	CLIP-seq
MIRT2208901	hsa-miR-3200-5p	CLIP-seq
MIRT2386683	hsa-miR-3616-3p	CLIP-seq
MIRT2386684	hsa-miR-4638-3p	CLIP-seq
MIRT2447979	hsa-miR-324-5p	CLIP-seq
MIRT2447980	hsa-miR-3529	CLIP-seq
MIRT2447981	hsa-miR-379	CLIP-seq
MIRT2447982	hsa-miR-3910	CLIP-seq
MIRT2447983	hsa-miR-4292	CLIP-seq
MIRT2447984	hsa-miR-4308	CLIP-seq
MIRT2447985	hsa-miR-4451	CLIP-seq
MIRT2447986	hsa-miR-4493	CLIP-seq
MIRT2447987	hsa-miR-4650-3p	CLIP-seq
MIRT2512676	hsa-miR-1233	CLIP-seq
MIRT2512677	hsa-miR-125a-5p	CLIP-seq
MIRT2512678	hsa-miR-125b	CLIP-seq
MIRT2512679	hsa-miR-1913	CLIP-seq
MIRT2512680	hsa-miR-3184	CLIP-seq
MIRT2512681	hsa-miR-324-3p	CLIP-seq
MIRT2512682	hsa-miR-331-3p	CLIP-seq
MIRT2512683	hsa-miR-423-5p	CLIP-seq
MIRT2512684	hsa-miR-4290	CLIP-seq
MIRT2512685	hsa-miR-4319	CLIP-seq
MIRT2512686	hsa-miR-4687-5p	CLIP-seq
MIRT2512687	hsa-miR-4749-3p	CLIP-seq
MIRT2512688	hsa-miR-4752	CLIP-seq
MIRT2512689	hsa-miR-544b	CLIP-seq
MIRT2512690	hsa-miR-563	CLIP-seq
MIRT2512691	hsa-miR-670	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0021516	Process	Dorsal spinal cord development	ISS
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0048715	Process	Negative regulation of oligodendrocyte differentiation	IBA	21873635
GO:0048715	Process	Negative regulation of oligodendrocyte differentiation	ISS
GO:0060828	Process	Regulation of canonical Wnt signaling pathway	ISS
GO:0070062	Component	Extracellular exosome	HDA	18570454
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA	21873635
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	ISS
GO:2000050	Process	Regulation of non-canonical Wnt signaling pathway	IBA	21873635
GO:2000050	Process	Regulation of non-canonical Wnt signaling pathway	ISS

MIM	HGNC	e!Ensembl
606627	18143	ENSG00000146122

Protein

UniProt ID

Protein name

Disheveled-associated activator of morphogenesis 2

Protein function

Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06371	Drf_GBD	40 → 228	Diaphanous GTPase-binding Domain	Family
PF06367	Drf_FH3	231 → 435	Diaphanous FH3 Domain	Family
PF02181	FH2	595 → 969	Formin Homology 2 Domain	Family

Sequence

MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELD
LTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDE
EETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGC
IKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAM
LHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL
RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMF
ELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDL
APLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMM
RTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDL
PPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQ
PSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDI
YLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFI
PEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVE
AILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNIS
LLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRR
QVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGI
FDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEG
GEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY

Sequence length

1068

Interactions

View interactions

	KEGG
	Wnt signaling pathway Cytoskeleton in muscle cells

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	30598549
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19358997

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