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NCS1 (neuronal calcium sensor 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23413
Gene nameGene Name - the full gene name approved by the HGNC.
Neuronal calcium sensor 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
NCS1
SynonymsGene synonyms aliases
FLUP, FREQ
ChromosomeChromosome number
9
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.11
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019373 hsa-miR-148b-3p Microarray 17612493
MIRT021815 hsa-miR-132-3p Microarray 17612493
MIRT023761 hsa-miR-1-3p Proteomics 18668040
MIRT043837 hsa-miR-330-3p CLASH 23622248
MIRT043430 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IEA
GO:0005245 Function Voltage-gated calcium channel activity ISS
GO:0005509 Function Calcium ion binding TAS 11092894
GO:0005515 Function Protein binding IPI 12783849, 16189514, 21516116, 25416956, 32296183
GO:0005737 Component Cytoplasm IDA 12783849
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P62166
Protein name Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)
Protein function Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity
PDB 1G8I , 2LCP , 4GUK , 5O9S , 6QI4 , 8AHY , 8ALH , 8ALM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00036 EF-hand_1
65 92
EF hand
Domain
PF13499 EF-hand_7
98 174
EF-hand domain pair
Domain
PF00036 EF-hand_1
148 175
EF hand
Domain
Sequence
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGD
PTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE
MLDIVDAIYQMVGNTVELPEEENTPEK
RVDRIFAMMDKNADGKLTLQEFQEGSKADPSIV
QALSLYDGLV
Sequence length 190
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 23535033
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 15364041, 24631552
Unknown
Disease name Disease term dbSNP ID References
Bipolar disorder Bipolar Disorder 24631552, 16691292

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