USP24 (ubiquitin specific peptidase 24)

Gene

• Entrez ID: 23358
• Gene name: Ubiquitin specific peptidase 24
• Gene symbol: USP24
• Synonyms: -
• Chromosome: 1
• Chromosome location: 1p32.3
• Summary: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1557523211	G>A	Likely-pathogenic	Intron variant, genic downstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026075	hsa-miR-196a-5p	Sequencing	20371350
MIRT032176	hsa-let-7d-5p	Sequencing	20371350
MIRT047289	hsa-miR-181b-5p	CLASH	23622248
MIRT041365	hsa-miR-193b-3p	CLASH	23622248
MIRT041365	hsa-miR-193b-3p	CLASH	23622248
MIRT036649	hsa-miR-935	CLASH	23622248
MIRT036516	hsa-miR-1226-3p	CLASH	23622248
MIRT734673	hsa-miR-139-5p	pSILAC, RNA-seq	33573268
MIRT1478337	hsa-miR-103a	CLIP-seq
MIRT1478338	hsa-miR-107	CLIP-seq
MIRT1478339	hsa-miR-1200	CLIP-seq
MIRT1478340	hsa-miR-1224-5p	CLIP-seq
MIRT1478341	hsa-miR-1234	CLIP-seq
MIRT1478342	hsa-miR-1273f	CLIP-seq
MIRT1478343	hsa-miR-1301	CLIP-seq
MIRT1478344	hsa-miR-143	CLIP-seq
MIRT1478345	hsa-miR-146a	CLIP-seq
MIRT1478346	hsa-miR-146b-5p	CLIP-seq
MIRT1478347	hsa-miR-150	CLIP-seq
MIRT1478348	hsa-miR-1915	CLIP-seq
MIRT1478349	hsa-miR-199a-5p	CLIP-seq
MIRT1478350	hsa-miR-199b-5p	CLIP-seq
MIRT1478351	hsa-miR-2053	CLIP-seq
MIRT1478352	hsa-miR-3124-3p	CLIP-seq
MIRT1478353	hsa-miR-3150b-3p	CLIP-seq
MIRT1478354	hsa-miR-3156-3p	CLIP-seq
MIRT1478355	hsa-miR-3156-5p	CLIP-seq
MIRT1478356	hsa-miR-338-3p	CLIP-seq
MIRT1478357	hsa-miR-338-5p	CLIP-seq
MIRT1478358	hsa-miR-3682-3p	CLIP-seq
MIRT1478359	hsa-miR-3691-5p	CLIP-seq
MIRT1478360	hsa-miR-3911	CLIP-seq
MIRT1478361	hsa-miR-3915	CLIP-seq
MIRT1478362	hsa-miR-4276	CLIP-seq
MIRT1478363	hsa-miR-4300	CLIP-seq
MIRT1478364	hsa-miR-4301	CLIP-seq
MIRT1478365	hsa-miR-4302	CLIP-seq
MIRT1478366	hsa-miR-4310	CLIP-seq
MIRT1478367	hsa-miR-4317	CLIP-seq
MIRT1478368	hsa-miR-4324	CLIP-seq
MIRT1478369	hsa-miR-4461	CLIP-seq
MIRT1478370	hsa-miR-4475	CLIP-seq
MIRT1478371	hsa-miR-4529-5p	CLIP-seq
MIRT1478372	hsa-miR-4689	CLIP-seq
MIRT1478373	hsa-miR-4693-3p	CLIP-seq
MIRT1478374	hsa-miR-4708-5p	CLIP-seq
MIRT1478375	hsa-miR-4713-5p	CLIP-seq
MIRT1478376	hsa-miR-4726-3p	CLIP-seq
MIRT1478377	hsa-miR-4733-5p	CLIP-seq
MIRT1478378	hsa-miR-4752	CLIP-seq
MIRT1478379	hsa-miR-4770	CLIP-seq
MIRT1478380	hsa-miR-4784	CLIP-seq
MIRT1478381	hsa-miR-498	CLIP-seq
MIRT1478382	hsa-miR-5047	CLIP-seq
MIRT1478383	hsa-miR-526b	CLIP-seq
MIRT1478384	hsa-miR-532-3p	CLIP-seq
MIRT1478385	hsa-miR-532-5p	CLIP-seq
MIRT1478386	hsa-miR-544b	CLIP-seq
MIRT1478387	hsa-miR-569	CLIP-seq
MIRT1478388	hsa-miR-580	CLIP-seq
MIRT1478389	hsa-miR-589	CLIP-seq
MIRT1478390	hsa-miR-616	CLIP-seq
MIRT1478391	hsa-miR-920	CLIP-seq
MIRT1478341	hsa-miR-1234	CLIP-seq
MIRT2144081	hsa-miR-145	CLIP-seq
MIRT1478345	hsa-miR-146a	CLIP-seq
MIRT1478346	hsa-miR-146b-5p	CLIP-seq
MIRT2144082	hsa-miR-214	CLIP-seq
MIRT1478355	hsa-miR-3156-5p	CLIP-seq
MIRT2144083	hsa-miR-3619-5p	CLIP-seq
MIRT2144084	hsa-miR-4291	CLIP-seq
MIRT1478363	hsa-miR-4300	CLIP-seq
MIRT1478366	hsa-miR-4310	CLIP-seq
MIRT1478369	hsa-miR-4461	CLIP-seq
MIRT2144085	hsa-miR-4663	CLIP-seq
MIRT2144086	hsa-miR-4712-5p	CLIP-seq
MIRT1478383	hsa-miR-526b	CLIP-seq
MIRT2144087	hsa-miR-548ag	CLIP-seq
MIRT2144088	hsa-miR-548ai	CLIP-seq
MIRT1478388	hsa-miR-580	CLIP-seq
MIRT2144089	hsa-miR-582-5p	CLIP-seq
MIRT1478389	hsa-miR-589	CLIP-seq
MIRT2144090	hsa-miR-622	CLIP-seq
MIRT2144091	hsa-miR-657	CLIP-seq
MIRT2144092	hsa-miR-761	CLIP-seq
MIRT2144093	hsa-miR-770-5p	CLIP-seq
MIRT1478391	hsa-miR-920	CLIP-seq
MIRT2144094	hsa-miR-922	CLIP-seq
MIRT1478339	hsa-miR-1200	CLIP-seq
MIRT2364280	hsa-miR-1208	CLIP-seq
MIRT1478340	hsa-miR-1224-5p	CLIP-seq
MIRT2364281	hsa-miR-1228	CLIP-seq
MIRT2364282	hsa-miR-1236	CLIP-seq
MIRT2364283	hsa-miR-140-5p	CLIP-seq
MIRT2364284	hsa-miR-153	CLIP-seq
MIRT2364285	hsa-miR-1587	CLIP-seq
MIRT2364286	hsa-miR-18a	CLIP-seq
MIRT2364287	hsa-miR-18b	CLIP-seq
MIRT2364288	hsa-miR-21	CLIP-seq
MIRT2364289	hsa-miR-224	CLIP-seq
MIRT2364290	hsa-miR-296-3p	CLIP-seq
MIRT2364291	hsa-miR-3155	CLIP-seq
MIRT2364292	hsa-miR-3155b	CLIP-seq
MIRT2364293	hsa-miR-329	CLIP-seq
MIRT1478356	hsa-miR-338-3p	CLIP-seq
MIRT2364294	hsa-miR-362-3p	CLIP-seq
MIRT2364295	hsa-miR-3647-3p	CLIP-seq
MIRT2364296	hsa-miR-3674	CLIP-seq
MIRT1478358	hsa-miR-3682-3p	CLIP-seq
MIRT2364297	hsa-miR-371b-5p	CLIP-seq
MIRT2364298	hsa-miR-3920	CLIP-seq
MIRT2364299	hsa-miR-3925-3p	CLIP-seq
MIRT2364300	hsa-miR-4252	CLIP-seq
MIRT2364301	hsa-miR-4297	CLIP-seq
MIRT1478368	hsa-miR-4324	CLIP-seq
MIRT2364302	hsa-miR-4437	CLIP-seq
MIRT2364303	hsa-miR-4524	CLIP-seq
MIRT2364304	hsa-miR-4530	CLIP-seq
MIRT2364305	hsa-miR-4645-5p	CLIP-seq
MIRT2144085	hsa-miR-4663	CLIP-seq
MIRT2364306	hsa-miR-4673	CLIP-seq
MIRT2364307	hsa-miR-4674	CLIP-seq
MIRT2364308	hsa-miR-4690-5p	CLIP-seq
MIRT1478373	hsa-miR-4693-3p	CLIP-seq
MIRT2364309	hsa-miR-4710	CLIP-seq
MIRT2144086	hsa-miR-4712-5p	CLIP-seq
MIRT1478377	hsa-miR-4733-5p	CLIP-seq
MIRT2364310	hsa-miR-4735-3p	CLIP-seq
MIRT2364311	hsa-miR-4747-5p	CLIP-seq
MIRT2364312	hsa-miR-4762-3p	CLIP-seq
MIRT2364313	hsa-miR-4792	CLIP-seq
MIRT2364314	hsa-miR-483-3p	CLIP-seq
MIRT2364315	hsa-miR-484	CLIP-seq
MIRT2364316	hsa-miR-491-3p	CLIP-seq
MIRT2364317	hsa-miR-499-3p	CLIP-seq
MIRT2364318	hsa-miR-499a-3p	CLIP-seq
MIRT1478385	hsa-miR-532-5p	CLIP-seq
MIRT1478386	hsa-miR-544b	CLIP-seq
MIRT2364319	hsa-miR-545	CLIP-seq
MIRT2144087	hsa-miR-548ag	CLIP-seq
MIRT2144088	hsa-miR-548ai	CLIP-seq
MIRT2364320	hsa-miR-586	CLIP-seq
MIRT2364321	hsa-miR-590-5p	CLIP-seq
MIRT2364322	hsa-miR-640	CLIP-seq
MIRT2364323	hsa-miR-668	CLIP-seq
MIRT2364324	hsa-miR-766	CLIP-seq
MIRT2144093	hsa-miR-770-5p	CLIP-seq
MIRT2144082	hsa-miR-214	CLIP-seq
MIRT2144083	hsa-miR-3619-5p	CLIP-seq
MIRT2144084	hsa-miR-4291	CLIP-seq
MIRT2144091	hsa-miR-657	CLIP-seq
MIRT2144092	hsa-miR-761	CLIP-seq
MIRT2144094	hsa-miR-922	CLIP-seq
MIRT1478337	hsa-miR-103a	CLIP-seq
MIRT1478338	hsa-miR-107	CLIP-seq
MIRT2658056	hsa-miR-1183	CLIP-seq
MIRT2364280	hsa-miR-1208	CLIP-seq
MIRT1478340	hsa-miR-1224-5p	CLIP-seq
MIRT2658057	hsa-miR-1237	CLIP-seq
MIRT2658058	hsa-miR-124	CLIP-seq
MIRT2658059	hsa-miR-1248	CLIP-seq
MIRT2658060	hsa-miR-1257	CLIP-seq
MIRT1478342	hsa-miR-1273f	CLIP-seq
MIRT2658061	hsa-miR-1281	CLIP-seq
MIRT2658062	hsa-miR-1286	CLIP-seq
MIRT1478343	hsa-miR-1301	CLIP-seq
MIRT2364283	hsa-miR-140-5p	CLIP-seq
MIRT1478344	hsa-miR-143	CLIP-seq
MIRT2658063	hsa-miR-1468	CLIP-seq
MIRT2658064	hsa-miR-149	CLIP-seq
MIRT1478351	hsa-miR-2053	CLIP-seq
MIRT2144082	hsa-miR-214	CLIP-seq
MIRT2658065	hsa-miR-300	CLIP-seq
MIRT2658066	hsa-miR-302a	CLIP-seq
MIRT2658067	hsa-miR-302b	CLIP-seq
MIRT2658068	hsa-miR-302c	CLIP-seq
MIRT2658069	hsa-miR-302d	CLIP-seq
MIRT2658070	hsa-miR-302e	CLIP-seq
MIRT2658071	hsa-miR-3129-3p	CLIP-seq
MIRT2658072	hsa-miR-3136-5p	CLIP-seq
MIRT2658073	hsa-miR-3137	CLIP-seq
MIRT1478353	hsa-miR-3150b-3p	CLIP-seq
MIRT2658074	hsa-miR-3168	CLIP-seq
MIRT2658075	hsa-miR-3177-5p	CLIP-seq
MIRT2658076	hsa-miR-323-3p	CLIP-seq
MIRT1478357	hsa-miR-338-5p	CLIP-seq
MIRT2658077	hsa-miR-3609	CLIP-seq
MIRT2658078	hsa-miR-3613-5p	CLIP-seq
MIRT2144083	hsa-miR-3619-5p	CLIP-seq
MIRT2364295	hsa-miR-3647-3p	CLIP-seq
MIRT2658079	hsa-miR-3671	CLIP-seq
MIRT2658080	hsa-miR-3714	CLIP-seq
MIRT2658081	hsa-miR-371-5p	CLIP-seq
MIRT2364297	hsa-miR-371b-5p	CLIP-seq
MIRT2658082	hsa-miR-372	CLIP-seq
MIRT2658083	hsa-miR-373	CLIP-seq
MIRT2658084	hsa-miR-381	CLIP-seq
MIRT2658085	hsa-miR-3910	CLIP-seq
MIRT1478361	hsa-miR-3915	CLIP-seq
MIRT2658086	hsa-miR-409-5p	CLIP-seq
MIRT2364300	hsa-miR-4252	CLIP-seq
MIRT1478362	hsa-miR-4276	CLIP-seq
MIRT2658087	hsa-miR-4277	CLIP-seq
MIRT2144084	hsa-miR-4291	CLIP-seq
MIRT1478365	hsa-miR-4302	CLIP-seq
MIRT1478367	hsa-miR-4317	CLIP-seq
MIRT2658088	hsa-miR-4439	CLIP-seq
MIRT2658089	hsa-miR-4457	CLIP-seq
MIRT2658090	hsa-miR-4484	CLIP-seq
MIRT2658091	hsa-miR-4509	CLIP-seq
MIRT2658092	hsa-miR-4519	CLIP-seq
MIRT2658093	hsa-miR-4521	CLIP-seq
MIRT2658094	hsa-miR-4532	CLIP-seq
MIRT2658095	hsa-miR-4666-3p	CLIP-seq
MIRT2658096	hsa-miR-4684-5p	CLIP-seq
MIRT1478372	hsa-miR-4689	CLIP-seq
MIRT1478374	hsa-miR-4708-5p	CLIP-seq
MIRT2364309	hsa-miR-4710	CLIP-seq
MIRT2658097	hsa-miR-4738-3p	CLIP-seq
MIRT2658098	hsa-miR-4768-5p	CLIP-seq
MIRT1478379	hsa-miR-4770	CLIP-seq
MIRT1478380	hsa-miR-4784	CLIP-seq
MIRT2364313	hsa-miR-4792	CLIP-seq
MIRT2658099	hsa-miR-492	CLIP-seq
MIRT1478382	hsa-miR-5047	CLIP-seq
MIRT2658100	hsa-miR-506	CLIP-seq
MIRT2658101	hsa-miR-513b	CLIP-seq
MIRT2658102	hsa-miR-513c	CLIP-seq
MIRT2658103	hsa-miR-514b-5p	CLIP-seq
MIRT2658104	hsa-miR-519a	CLIP-seq
MIRT2658105	hsa-miR-519b-3p	CLIP-seq
MIRT2658106	hsa-miR-519c-3p	CLIP-seq
MIRT2658107	hsa-miR-520a-3p	CLIP-seq
MIRT2658108	hsa-miR-520b	CLIP-seq
MIRT2658109	hsa-miR-520c-3p	CLIP-seq
MIRT2658110	hsa-miR-520d-3p	CLIP-seq
MIRT2658111	hsa-miR-520e	CLIP-seq
MIRT2658112	hsa-miR-520g	CLIP-seq
MIRT2658113	hsa-miR-520h	CLIP-seq
MIRT2364319	hsa-miR-545	CLIP-seq
MIRT2658114	hsa-miR-548ad	CLIP-seq
MIRT2658115	hsa-miR-548ah	CLIP-seq
MIRT2658116	hsa-miR-548an	CLIP-seq
MIRT1478387	hsa-miR-569	CLIP-seq
MIRT2658117	hsa-miR-570	CLIP-seq
MIRT2144089	hsa-miR-582-5p	CLIP-seq
MIRT1478390	hsa-miR-616	CLIP-seq
MIRT2658118	hsa-miR-634	CLIP-seq
MIRT2364322	hsa-miR-640	CLIP-seq
MIRT2144091	hsa-miR-657	CLIP-seq
MIRT2364323	hsa-miR-668	CLIP-seq
MIRT2658119	hsa-miR-760	CLIP-seq
MIRT2144092	hsa-miR-761	CLIP-seq
MIRT2658120	hsa-miR-767-3p	CLIP-seq
MIRT2658121	hsa-miR-888	CLIP-seq
MIRT2658122	hsa-miR-892b	CLIP-seq
MIRT2144094	hsa-miR-922	CLIP-seq
MIRT2658123	hsa-miR-940	CLIP-seq
MIRT2658124	hsa-miR-942	CLIP-seq
MIRT2658125	hsa-miR-943	CLIP-seq
MIRT2658056	hsa-miR-1183	CLIP-seq
MIRT2364280	hsa-miR-1208	CLIP-seq
MIRT1478340	hsa-miR-1224-5p	CLIP-seq
MIRT2658057	hsa-miR-1237	CLIP-seq
MIRT2658059	hsa-miR-1248	CLIP-seq
MIRT2658060	hsa-miR-1257	CLIP-seq
MIRT2658064	hsa-miR-149	CLIP-seq
MIRT1478351	hsa-miR-2053	CLIP-seq
MIRT2144082	hsa-miR-214	CLIP-seq
MIRT2658065	hsa-miR-300	CLIP-seq
MIRT2658072	hsa-miR-3136-5p	CLIP-seq
MIRT2658073	hsa-miR-3137	CLIP-seq
MIRT1478353	hsa-miR-3150b-3p	CLIP-seq
MIRT2658075	hsa-miR-3177-5p	CLIP-seq
MIRT2658076	hsa-miR-323-3p	CLIP-seq
MIRT2694809	hsa-miR-323b-3p	CLIP-seq
MIRT1478357	hsa-miR-338-5p	CLIP-seq
MIRT2658078	hsa-miR-3613-5p	CLIP-seq
MIRT2144083	hsa-miR-3619-5p	CLIP-seq
MIRT2658079	hsa-miR-3671	CLIP-seq
MIRT2658081	hsa-miR-371-5p	CLIP-seq
MIRT2364297	hsa-miR-371b-5p	CLIP-seq
MIRT2658084	hsa-miR-381	CLIP-seq
MIRT1478361	hsa-miR-3915	CLIP-seq
MIRT2364300	hsa-miR-4252	CLIP-seq
MIRT1478362	hsa-miR-4276	CLIP-seq
MIRT2144084	hsa-miR-4291	CLIP-seq
MIRT1478365	hsa-miR-4302	CLIP-seq
MIRT2658088	hsa-miR-4439	CLIP-seq
MIRT2658089	hsa-miR-4457	CLIP-seq
MIRT2658092	hsa-miR-4519	CLIP-seq
MIRT2658094	hsa-miR-4532	CLIP-seq
MIRT2658095	hsa-miR-4666-3p	CLIP-seq
MIRT1478372	hsa-miR-4689	CLIP-seq
MIRT1478380	hsa-miR-4784	CLIP-seq
MIRT2658101	hsa-miR-513b	CLIP-seq
MIRT2658102	hsa-miR-513c	CLIP-seq
MIRT2658103	hsa-miR-514b-5p	CLIP-seq
MIRT2364319	hsa-miR-545	CLIP-seq
MIRT1478387	hsa-miR-569	CLIP-seq
MIRT2364322	hsa-miR-640	CLIP-seq
MIRT2144091	hsa-miR-657	CLIP-seq
MIRT2364323	hsa-miR-668	CLIP-seq
MIRT2658119	hsa-miR-760	CLIP-seq
MIRT2144092	hsa-miR-761	CLIP-seq
MIRT2658121	hsa-miR-888	CLIP-seq
MIRT2658122	hsa-miR-892b	CLIP-seq
MIRT2144094	hsa-miR-922	CLIP-seq
MIRT2658124	hsa-miR-942	CLIP-seq
MIRT2658125	hsa-miR-943	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA	21873635
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0016032	Process	Viral process	IEA
GO:0016579	Process	Protein deubiquitination	IBA	21873635
GO:0016579	Process	Protein deubiquitination	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA

Other IDs

• MIM: 610569
• HGNC: 12623
• e!Ensembl: ENSG00000162402

Protein

• UniProt ID: Q9UPU5
• Protein name: Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)
• Protein function: Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in l
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00443	UCH	1689 → 2039	Ubiquitin carboxyl-terminal hydrolase	Family
  PF12030	DUF3517	2219 → 2570	Domain of unknown function (DUF3517)	Family

• Sequence:

  MESEEEQHMTTLLCMGFSDPATIRKALRLAKNDINEAVALLTNERPGLDYGGYEPMDSGG
  GPSPGPGGGPRGDGGGDGGGGGPSRGGSTGGGGGFDPPPAYHEVVDAEKNDENGNCSGEG
  IEFPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDENCRRFMDRCM
  PEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQDPIPTGLLGVLTMAFNPDN
  EYHFKNRMKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELGGFAAIQAK
  LHSEDIELGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQDVRSVEEKDLKDKRLVS
  IPELLSAVKLLCMRFQPDLVTIVDDLRLDILLRMLKSPHFSAKMNSLKEVTKLIEDSTLS
  KSVKNAIDTDRLLDWLVENSVLSIALEGNIDQAQYCDRIKGIIELLGSKLSLDELTKIWK
  IQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQKSWETESDRVRQKLLSLIGRIGR
  EARFETTSGKVLDVLWELAHLPTLPSSLIQQALEEHLTILSDAYAVKEAIKRSYIIKCIE
  DIKRPGEWSGLEKNKKDGFKSSQLNNPQFVWVVPALRQLHEITRSFIKQTYQKQDKSIIQ
  DLKKNFEIVKLVTGSLIACHRLAAAVAGPGGLSGSTLVDGRYTYREYLEAHLKFLAFFLQ
  EATLYLGWNRAKEIWECLVTGQDVCELDREMCFEWFTKGQHDLESDVQQQLFKEKILKLE
  SYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYVEKLELIGMDFIWKIAMESPDEEIAN
  EAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAASSALGGPTLTHAVTRATKML
  TATAMPTVATSVQSPYRSTKLVIIERLLLLAERYVITIEDFYSVPRTILPHGASFHGHLL
  TLNVTYESTKDTFTVEAHSNETIGSVRWKIAKQLCSPVDNIQIFTNDSLLTVNKDQKLLH
  QLGFSDEQILTVKTSGSGTPSGSSADSSTSSSSSSSGVFSSSYAMEQEKSLPGVVMALVC
  NVFDMLYQLANLEEPRITLRVRKLLLLIPTDPAIQEALDQLDSLGRKKTLLSESSSQSSK
  SPSLSSKQQHQPSASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPTADDDMARSCAKS
  FCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLLVGQTMPTLLDEDL
  TKDGIEALSSRPFRNVSRQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQ
  TMEVSDFTSTVACFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSG
  SEGEPVALHAGICVRQQSVSTKDSLIAGEALSLLVTCLQLRSQQLASFYNLPCVADFIID
  ILLGSPSAEIRRVACDQLYTLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGV
  NQRLLSQCMEYFDLRCQLLDDLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSE
  ADNILLAGHLRLIKTLLSLCGAEKEMLGSSLIKPLLDDFLFRASRIILNSHSPAGSAAIS
  QQDFHPKCSTANSRLAAYEVLVMLADSSPSNLQIIIKELLSMHHQPDPALTKEFDYLPPV
  DSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFG
  HLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKN
  TFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCE
  KCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGM
  ARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRG
  CGKGKWYKFNDTVIEEFDLNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQ
  RVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVK
  KGEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLKHPYYPC
  MAKVSLQLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFISSEGRE
  LIKIFLLECNVREVRVAVATILEKTLDSALFYQDKLKSLHQLLEVLLALLDKDVPENCKN
  CAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGASRQNNQIRRWSSAQAREFGNL
  HNTVALLVLHSDVSSQRNVAPGIFKQRPPISIAPSSPLLPLHEEVEALLFMSEGKPYLLE
  VMFALRELTGSLLALIEMVVYCCFCNEHFSFTMLHFIKNQLETAPPHELKNTFQLLHEIL
  VIEDPIQVERVKFVFETENGLLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKEN
  SHHWSWAVQWLQKKMSEHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATALLNEKEQSG
  SSNGSESSPANENGDRHLQQGSESPMMIGELRSDLDDVDP

• Sequence length: 2620

Pathways

Reactome:

Ub-specific processing proteases

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	25514360