ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A)

Gene

• Entrez ID: 23294
• Gene name: Ankyrin repeat and sterile alpha motif domain containing 1A
• Gene symbol: ANKS1A
• Synonyms: ANKS1
• Chromosome: 6
• Chromosome location: 6p21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049292	hsa-miR-92a-3p	CLASH	23622248
MIRT218696	hsa-miR-487a-5p	PAR-CLIP	21572407
MIRT218697	hsa-miR-509-3p	PAR-CLIP	21572407
MIRT218698	hsa-miR-487b-5p	PAR-CLIP	21572407
MIRT218699	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT218701	hsa-miR-6740-5p	PAR-CLIP	21572407
MIRT549364	hsa-miR-744-3p	PAR-CLIP	21572407
MIRT549365	hsa-miR-1263	PAR-CLIP	21572407
MIRT549366	hsa-miR-150-3p	PAR-CLIP	21572407
MIRT549367	hsa-miR-4777-3p	PAR-CLIP	21572407
MIRT549368	hsa-miR-4684-3p	PAR-CLIP	21572407
MIRT549369	hsa-miR-622	PAR-CLIP	21572407
MIRT549370	hsa-miR-4307	PAR-CLIP	21572407
MIRT717769	hsa-miR-513a-5p	HITS-CLIP	19536157
MIRT717770	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT717771	hsa-miR-4253	HITS-CLIP	19536157
MIRT717772	hsa-miR-3945	HITS-CLIP	19536157
MIRT717773	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT717774	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT717775	hsa-miR-6854-5p	HITS-CLIP	19536157
MIRT735973	hsa-miR-1205	PAR-CLIP	26701625
MIRT736618	hsa-miR-125a-3p	PAR-CLIP	26701625
MIRT741096	hsa-miR-3197	PAR-CLIP	26701625
MIRT741432	hsa-miR-34a-5p	PAR-CLIP	26701625
MIRT741473	hsa-miR-34c-5p	PAR-CLIP	26701625
MIRT742034	hsa-miR-3665	PAR-CLIP	26701625
MIRT743988	hsa-miR-4316	PAR-CLIP	26701625
MIRT745396	hsa-miR-449a	PAR-CLIP	26701625
MIRT745428	hsa-miR-449b-5p	PAR-CLIP	26701625
MIRT747389	hsa-miR-4710	PAR-CLIP	26701625
MIRT750603	hsa-miR-548au-3p	PAR-CLIP	26701625
MIRT751034	hsa-miR-558	PAR-CLIP	26701625
MIRT751897	hsa-miR-6087	PAR-CLIP	26701625
MIRT753495	hsa-miR-657	PAR-CLIP	26701625
MIRT753729	hsa-miR-6717-5p	PAR-CLIP	26701625
MIRT755070	hsa-miR-6765-5p	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 24658140, 31980649
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006929	Process	Substrate-dependent cell migration	ISS
GO:0016322	Process	Neuron remodeling	ISS
GO:0043005	Component	Neuron projection	ISS
GO:0046875	Function	Ephrin receptor binding	IBA	21873635
GO:0048013	Process	Ephrin receptor signaling pathway	IBA	21873635
GO:0048013	Process	Ephrin receptor signaling pathway	ISS
GO:1901187	Process	Regulation of ephrin receptor signaling pathway	IEA

Other IDs

• MIM: 608994
• HGNC: 20961
• e!Ensembl: ENSG00000064999

Protein

• UniProt ID: Q92625
• Protein name: Ankyrin repeat and SAM domain-containing protein 1A (Odin)
• Protein function: Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).
• PDB: 2LMR, 2MYQ, 6F7O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00023	Ank	79 → 111	Ankyrin repeat	Repeat
  PF00023	Ank	112 → 147	Ankyrin repeat	Repeat
  PF00023	Ank	148 → 180	Ankyrin repeat	Repeat
  PF00023	Ank	215 → 246	Ankyrin repeat	Repeat
  PF00023	Ank	249 → 278	Ankyrin repeat	Repeat
  PF00536	SAM_1	696 → 760	SAM domain (Sterile alpha motif)	Domain
  PF00536	SAM_1	768 → 832	SAM domain (Sterile alpha motif)	Domain
  PF00640	PID	942 → 1068	Phosphotyrosine interaction domain (PTB/PID)	Domain

• Sequence:

  MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP
  LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA
  AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN
  KFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMD
  SNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVRELPSQKSQQIAA
  LIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTELIIDFDANAEEEGP
  YEALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVKPAGVRPRERPPPPAKPPPDEEEE
  DHIDKKYFPLTASEVLSMRPRIHGSAAREEDEHPYELLLTAETKKVVLVDGKTKDHRRSS
  SSRSQDSAEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLCTAGQSHPDGSPQQGACHKA
  SMQLEETGVHAPGASQPSALDQSKRVGYLTGLPTTNSRSHPETLTHTASPHPGGAEEGDR
  SGARSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEK
  SPSFASEWDEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLN
  GFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLD
  SLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLLGHRKRIIASLADRPYEEPPQK
  PPRFSQLRCQDLLSQTSSPLSQNDSCTGRSADLLLPPGDTGRRRHDSLHDPAAPSRAERF
  RIQEEHREAKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTES
  TQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLC
  TFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRATGASAAE
  MIETKSSKPVPKPRVGVRKSALEPPDMDQDAQSHASVSWVVDPKPDSKRSLSTN

• Sequence length: 1134

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	21378990
Coronary heart disease	Coronary heart disease	rs-1	21378990

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary arteriosclerosis	Coronary Arteriosclerosis		21378990
Lupus erythematosus	Lupus Erythematosus, Systemic		26502338, 23740937
Scleroderma	Systemic Scleroderma		23740937