MTCL1 (microtubule crosslinking factor 1)

Gene

• Entrez ID: 23255
• Gene name: Microtubule crosslinking factor 1
• Gene symbol: MTCL1
• Synonyms: CCDC165, KIAA0802, SOGA2
• Chromosome: 18
• Chromosome location: 18p11.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439564	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT439565	hsa-miR-543	HITS-CLIP	24374217
MIRT439564	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT439565	hsa-miR-543	HITS-CLIP	24374217
MIRT740601	hsa-miR-6499-5p	HITS-CLIP	19536157
MIRT740602	hsa-miR-5695	HITS-CLIP	19536157
MIRT740603	hsa-miR-4268	HITS-CLIP	19536157
MIRT740604	hsa-miR-4448	HITS-CLIP	19536157
MIRT740605	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT740606	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT740607	hsa-miR-6788-3p	HITS-CLIP	19536157
MIRT740608	hsa-miR-4750-5p	HITS-CLIP	19536157
MIRT740609	hsa-miR-6772-3p	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IBA	21873635
GO:0000922	Component	Spindle pole	IDA	23902687
GO:0001578	Process	Microtubule bundle formation	IBA	21873635
GO:0001578	Process	Microtubule bundle formation	ISS
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IDA	23902687
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0008017	Function	Microtubule binding	IDA	23902687
GO:0010506	Process	Regulation of autophagy	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016327	Component	Apicolateral plasma membrane	IBA	21873635
GO:0016327	Component	Apicolateral plasma membrane	ISS
GO:0016328	Component	Lateral plasma membrane	IBA	21873635
GO:0016328	Component	Lateral plasma membrane	ISS
GO:0030496	Component	Midbody	IBA	21873635
GO:0030496	Component	Midbody	IDA	23902687
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0045197	Process	Establishment or maintenance of epithelial cell apical/basal polarity	IBA	21873635
GO:0045197	Process	Establishment or maintenance of epithelial cell apical/basal polarity	ISS
GO:0090314	Process	Positive regulation of protein targeting to membrane	ISS
GO:0097427	Component	Microtubule bundle	IBA	21873635
GO:0097427	Component	Microtubule bundle	ISS
GO:2000576	Process	Positive regulation of microtubule motor activity	ISS

Other IDs

• MIM: 615766
• HGNC: 29121
• e!Ensembl: ENSG00000168502

Protein

• UniProt ID: Q9Y4B5
• Protein name: Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2)
• Protein function: Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral memb
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11365	SOGA	501 → 595	Protein SOGA	Coiled-coil
  PF11365	SOGA	630 → 722	Protein SOGA	Coiled-coil
  PF14818	DUF4482	1228 → 1351	Domain of unknown function (DUF4482)	Family

• Sequence:

  METLNGPAGGGAPDAKLQPPGQHHRHHHLHPVAERRRLHRAPSPARPFLKDLHARPAAPG
  PAVPSSGRAPAPAAPRSPNLAGKAPPSPGSLAAPGRLSRRSGGVPGAKDKPPPGAGARAA
  GGAKAALGSRRAARVAPAEPLSRAGKPPGAEPPSAAAKGRKAKRGSRAPPARTVGPPTPA
  ARIPAVTLAVTSVAGSPARCSRISHTDSSSDLSDCPSEPLSDEQRLLPAASSDAESGTGS
  SDREPPRGAPTPSPAARGAPPGSPEPPALLAAPLAAGACPGGRSIPSGVSGGFAGPGVAE
  DVRGRSPPERPVPGTPKEPSLGEQSRLVPAAEEEELLREMEELRSENDYLKDELDELRAE
  MEEMRDSYLEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRS
  LEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKES
  SLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKY
  KSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEME
  DMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNR
  QLTHELSKFKFEPPREPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENH
  ALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEE
  MFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLH
  DAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGL
  SPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLR
  LRAARELHRRADGDTGSHGLGGQTCFSLEMEEEHLYALRWKELEMHSLALQNTLHERTWS
  DEKNLMQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEEGEEFTEGEHPETLSRLGELG
  VQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFS
  AFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELG
  SSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWE
  RQKKEFLWRIEQLQKENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSI
  PFEDRPLSKLKESDRCSASENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNL
  QRAVSVSSMSEFQRLMDISPFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPN
  RGHNGGGPDLWADRTEVGRAGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRS
  HVLTEQSGLRVLHSPPAVRRVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCT
  SPRHSRDYVEGARRPLDSPLCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGE
  LQVKDMACQTNGSRTMGTQTVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSP
  SRSLRSRQVAPAIEKVQAKFERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSE
  SAWARSTTTRESPVHTTINDGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGP
  GQETGTNSRGRSPSPIGVGSEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEH
  ALKEERRQAAHGPPGLHSDSHSLGDTAEPGPMENQTVLLTAPWGL

• Sequence length: 1905

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	28166215, 30804561