ATP11A (ATPase phospholipid transporting 11A)

Gene

• Entrez ID: 23250
• Gene name: ATPase phospholipid transporting 11A
• Gene symbol: ATP11A
• Synonyms: ATPIH, ATPIS
• Chromosome: 13
• Chromosome location: 13q34
• Summary: The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT037411	hsa-miR-744-5p	CLASH	23622248
MIRT039140	hsa-miR-769-5p	CLASH	23622248
MIRT042225	hsa-miR-484	CLASH	23622248
MIRT048064	hsa-miR-197-3p	CLASH	23622248
MIRT049412	hsa-miR-92a-3p	CLASH	23622248
MIRT705415	hsa-miR-4777-5p	HITS-CLIP	23313552
MIRT705416	hsa-miR-523-5p	HITS-CLIP	23313552
MIRT705417	hsa-miR-526a	HITS-CLIP	23313552
MIRT705418	hsa-miR-522-5p	HITS-CLIP	23313552
MIRT705419	hsa-miR-520c-5p	HITS-CLIP	23313552
MIRT705420	hsa-miR-519c-5p	HITS-CLIP	23313552
MIRT705421	hsa-miR-519b-5p	HITS-CLIP	23313552
MIRT705422	hsa-miR-519a-5p	HITS-CLIP	23313552
MIRT705423	hsa-miR-518f-5p	HITS-CLIP	23313552
MIRT705424	hsa-miR-518e-5p	HITS-CLIP	23313552
MIRT705425	hsa-miR-518d-5p	HITS-CLIP	23313552
MIRT705426	hsa-miR-337-3p	HITS-CLIP	23313552
MIRT705427	hsa-miR-202-5p	HITS-CLIP	23313552
MIRT705428	hsa-miR-365b-5p	HITS-CLIP	23313552
MIRT705429	hsa-miR-365a-5p	HITS-CLIP	23313552
MIRT705430	hsa-miR-617	HITS-CLIP	23313552
MIRT705431	hsa-miR-8067	HITS-CLIP	23313552
MIRT705432	hsa-miR-6508-5p	HITS-CLIP	23313552
MIRT705433	hsa-miR-770-5p	HITS-CLIP	23313552
MIRT705434	hsa-miR-4712-5p	HITS-CLIP	23313552
MIRT705435	hsa-miR-211-3p	HITS-CLIP	23313552
MIRT705436	hsa-miR-5680	HITS-CLIP	23313552
MIRT705437	hsa-miR-3121-3p	HITS-CLIP	23313552

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	21914794, 25947375
GO:0005524	Function	ATP binding	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005769	Component	Early endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	21914794
GO:0005802	Component	Trans-Golgi network	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IDA	25315773
GO:0016020	Component	Membrane	HDA	19946888
GO:0035579	Component	Specific granule membrane	TAS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045332	Process	Phospholipid translocation	IBA	21873635
GO:0045332	Process	Phospholipid translocation	NAS	21914794
GO:0055037	Component	Recycling endosome	IBA	21873635
GO:0055037	Component	Recycling endosome	IDA	21914794
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0090555	Function	Phosphatidylethanolamine flippase activity	IDA	25315773, 25947375
GO:0140326	Function	ATPase-coupled intramembrane lipid transporter activity	IBA	21873635
GO:0140331	Process	Aminophospholipid translocation	IEA
GO:0140346	Function	Phosphatidylserine flippase activity	IDA	25315773, 25947375
GO:1990531	Component	Phospholipid-translocating ATPase complex	IDA	25947375

Other IDs

• MIM: 605868
• HGNC: 13552
• e!Ensembl: ENSG00000068650

Protein

• UniProt ID: P98196
• Protein name: Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A)
• Protein function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:25315773, PubMed:25947375, PubMed:26567335, PubMed:29799007, PubMed:30018401). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation (PubMed:29799007). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16209	PhoLip_ATPase_N	26 → 97	Phospholipid-translocating ATPase N-terminal	Family
  PF00122	E1-E2_ATPase	124 → 377		Family
  PF13246	Cation_ATPase	476 → 587		Family
  PF16212	PhoLip_ATPase_C	851 → 1103	Phospholipid-translocating P-type ATPase C-terminal	Family

• Sequence:

  MDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNF
  IPKNLFEQFRRVANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHK
  ADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRGDGTCHVTT
  ASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPV
  VRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVY
  LCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDFLAFMVLFNYII
  PVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLT
  ENNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHT
  VQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNREN
  HIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVER
  NAVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATA
  VEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIEE
  QSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNY
  RELFLEICRSCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGI
  GVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLY
  QFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALL
  RWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSNGQIFGNWTFGTLVFTVMVFTVTLKL
  ALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYYVFIQMLSSGPAWLAIV
  LLVTISLLPDVLKKVLCRQLWPTATERVQTKSQCLSVEQSTIFMLSQTSSSLSF

• Sequence length: 1134

Pathways

KEGG:

Efferocytosis

Reactome:

Neutrophil degranulation
Ion transport by P-type ATPases

Associated diseases

Disease name	Disease term	References
	Basal Cell Neoplasm	31174203
	Basal Cell Cancer	31174203
	Bronchiectasis
	Basal cell carcinoma	31174203
	Hamman-Rich Disease	23583980
	Gastroesophageal reflux disease
	Honeycomb lung
	Lung Diseases, Interstitial	23583980
	Pulmonary Fibrosis
	Idiopathic Pulmonary Fibrosis	23583980
	Familial Idiopathic Pulmonary Fibrosis	23583980
	Hamman-Rich syndrome	23583980