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ARC (activity regulated cytoskeleton associated protein)

Gene

23237

Activity regulated cytoskeleton associated protein

ARC

Arg3.1, hArc

8q24.3

Show/Hide all(191)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043974	hsa-miR-378a-5p	CLASH	23622248
MIRT053767	hsa-miR-185-5p	Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	24763054
MIRT053767	hsa-miR-185-5p	Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	24763054
MIRT053767	hsa-miR-185-5p	Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	24763054
MIRT053767	hsa-miR-185-5p	Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	24763054
MIRT549357	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT549356	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT549355	hsa-miR-135b-5p	PAR-CLIP	21572407
MIRT549354	hsa-miR-135a-5p	PAR-CLIP	21572407
MIRT549353	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT549351	hsa-miR-3163	PAR-CLIP	21572407
MIRT549352	hsa-miR-889-5p	PAR-CLIP	21572407
MIRT549350	hsa-miR-455-5p	PAR-CLIP	21572407
MIRT549349	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT549348	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT549347	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT549346	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT549345	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT549344	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT549343	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT549342	hsa-miR-8074	PAR-CLIP	21572407
MIRT549341	hsa-miR-548aw	PAR-CLIP	21572407
MIRT494753	hsa-miR-3141	PAR-CLIP	22012620
MIRT494752	hsa-miR-6746-5p	PAR-CLIP	22012620
MIRT529160	hsa-miR-4469	PAR-CLIP	22012620
MIRT529159	hsa-miR-2467-5p	PAR-CLIP	22012620
MIRT494750	hsa-miR-3195	PAR-CLIP	22012620
MIRT494751	hsa-miR-3960	PAR-CLIP	22012620
MIRT494749	hsa-miR-8072	PAR-CLIP	22012620
MIRT529158	hsa-miR-7106-3p	PAR-CLIP	22012620
MIRT494748	hsa-miR-4467	PAR-CLIP	22012620
MIRT494747	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT494746	hsa-miR-8085	PAR-CLIP	22012620
MIRT494753	hsa-miR-3141	PAR-CLIP	23592263
MIRT494752	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT494750	hsa-miR-3195	PAR-CLIP	23592263
MIRT494751	hsa-miR-3960	PAR-CLIP	23592263
MIRT494749	hsa-miR-8072	PAR-CLIP	23592263
MIRT494748	hsa-miR-4467	PAR-CLIP	23592263
MIRT494747	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT494746	hsa-miR-8085	PAR-CLIP	23592263
MIRT494753	hsa-miR-3141	PAR-CLIP	26701625
MIRT494750	hsa-miR-3195	PAR-CLIP	26701625
MIRT494751	hsa-miR-3960	PAR-CLIP	26701625
MIRT494748	hsa-miR-4467	PAR-CLIP	26701625
MIRT494747	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT494752	hsa-miR-6746-5p	PAR-CLIP	26701625
MIRT494749	hsa-miR-8072	PAR-CLIP	26701625
MIRT494746	hsa-miR-8085	PAR-CLIP	26701625
MIRT549357	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT549356	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT549355	hsa-miR-135b-5p	PAR-CLIP	21572407
MIRT549354	hsa-miR-135a-5p	PAR-CLIP	21572407
MIRT549353	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT549351	hsa-miR-3163	PAR-CLIP	21572407
MIRT549352	hsa-miR-889-5p	PAR-CLIP	21572407
MIRT549350	hsa-miR-455-5p	PAR-CLIP	21572407
MIRT549349	hsa-miR-7114-5p	PAR-CLIP	21572407
MIRT549348	hsa-miR-134-3p	PAR-CLIP	21572407
MIRT549347	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT549346	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT549345	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT549344	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT549343	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT549342	hsa-miR-8074	PAR-CLIP	21572407
MIRT549341	hsa-miR-548aw	PAR-CLIP	21572407
MIRT494753	hsa-miR-3141	PAR-CLIP	22012620
MIRT494752	hsa-miR-6746-5p	PAR-CLIP	22012620
MIRT529160	hsa-miR-4469	PAR-CLIP	22012620
MIRT529159	hsa-miR-2467-5p	PAR-CLIP	22012620
MIRT494750	hsa-miR-3195	PAR-CLIP	22012620
MIRT494751	hsa-miR-3960	PAR-CLIP	22012620
MIRT494749	hsa-miR-8072	PAR-CLIP	22012620
MIRT529158	hsa-miR-7106-3p	PAR-CLIP	22012620
MIRT494748	hsa-miR-4467	PAR-CLIP	22012620
MIRT494747	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT494746	hsa-miR-8085	PAR-CLIP	22012620
MIRT494753	hsa-miR-3141	PAR-CLIP	23592263
MIRT494752	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT494750	hsa-miR-3195	PAR-CLIP	23592263
MIRT494751	hsa-miR-3960	PAR-CLIP	23592263
MIRT494749	hsa-miR-8072	PAR-CLIP	23592263
MIRT494748	hsa-miR-4467	PAR-CLIP	23592263
MIRT494747	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT494746	hsa-miR-8085	PAR-CLIP	23592263
MIRT791721	hsa-miR-1205	CLIP-seq
MIRT791722	hsa-miR-1207-3p	CLIP-seq
MIRT791723	hsa-miR-1207-5p	CLIP-seq
MIRT791724	hsa-miR-1254	CLIP-seq
MIRT791725	hsa-miR-1286	CLIP-seq
MIRT791726	hsa-miR-1299	CLIP-seq
MIRT791727	hsa-miR-1587	CLIP-seq
MIRT791728	hsa-miR-18a	CLIP-seq
MIRT791729	hsa-miR-18b	CLIP-seq
MIRT791730	hsa-miR-198	CLIP-seq
MIRT791731	hsa-miR-2861	CLIP-seq
MIRT791732	hsa-miR-2964a-5p	CLIP-seq
MIRT791733	hsa-miR-3116	CLIP-seq
MIRT791734	hsa-miR-3120-5p	CLIP-seq
MIRT791735	hsa-miR-3151	CLIP-seq
MIRT791736	hsa-miR-3158-3p	CLIP-seq
MIRT791737	hsa-miR-320e	CLIP-seq
MIRT791738	hsa-miR-326	CLIP-seq
MIRT791739	hsa-miR-330-5p	CLIP-seq
MIRT791740	hsa-miR-331-3p	CLIP-seq
MIRT791741	hsa-miR-342-5p	CLIP-seq
MIRT791742	hsa-miR-3614-5p	CLIP-seq
MIRT791743	hsa-miR-3619-3p	CLIP-seq
MIRT791744	hsa-miR-3687	CLIP-seq
MIRT791745	hsa-miR-3918	CLIP-seq
MIRT791746	hsa-miR-4265	CLIP-seq
MIRT791747	hsa-miR-4283	CLIP-seq
MIRT791748	hsa-miR-4296	CLIP-seq
MIRT791749	hsa-miR-4322	CLIP-seq
MIRT791750	hsa-miR-4323	CLIP-seq
MIRT791751	hsa-miR-4417	CLIP-seq
MIRT791752	hsa-miR-4433	CLIP-seq
MIRT791753	hsa-miR-4442	CLIP-seq
MIRT791754	hsa-miR-4447	CLIP-seq
MIRT791755	hsa-miR-4455	CLIP-seq
MIRT791756	hsa-miR-4472	CLIP-seq
MIRT791757	hsa-miR-4489	CLIP-seq
MIRT791758	hsa-miR-4492	CLIP-seq
MIRT791759	hsa-miR-4498	CLIP-seq
MIRT791760	hsa-miR-4512	CLIP-seq
MIRT791761	hsa-miR-4651	CLIP-seq
MIRT791762	hsa-miR-4656	CLIP-seq
MIRT791763	hsa-miR-4664-5p	CLIP-seq
MIRT791764	hsa-miR-4667-5p	CLIP-seq
MIRT791765	hsa-miR-4675	CLIP-seq
MIRT791766	hsa-miR-4677-3p	CLIP-seq
MIRT791767	hsa-miR-4679	CLIP-seq
MIRT791768	hsa-miR-4685-5p	CLIP-seq
MIRT791769	hsa-miR-4690-3p	CLIP-seq
MIRT791770	hsa-miR-4700-5p	CLIP-seq
MIRT791771	hsa-miR-4722-5p	CLIP-seq
MIRT791772	hsa-miR-4731-5p	CLIP-seq
MIRT791773	hsa-miR-4735-3p	CLIP-seq
MIRT791774	hsa-miR-4736	CLIP-seq
MIRT791775	hsa-miR-4741	CLIP-seq
MIRT791776	hsa-miR-4763-3p	CLIP-seq
MIRT791777	hsa-miR-4764-5p	CLIP-seq
MIRT791778	hsa-miR-4776-5p	CLIP-seq
MIRT791779	hsa-miR-4782-5p	CLIP-seq
MIRT791780	hsa-miR-491-5p	CLIP-seq
MIRT791781	hsa-miR-516b	CLIP-seq
MIRT791782	hsa-miR-555	CLIP-seq
MIRT791783	hsa-miR-593	CLIP-seq
MIRT791784	hsa-miR-608	CLIP-seq
MIRT791785	hsa-miR-609	CLIP-seq
MIRT791786	hsa-miR-637	CLIP-seq
MIRT791787	hsa-miR-762	CLIP-seq
MIRT1933600	hsa-miR-2276	CLIP-seq
MIRT1933601	hsa-miR-3160-3p	CLIP-seq
MIRT1933602	hsa-miR-3184	CLIP-seq
MIRT1933603	hsa-miR-423-5p	CLIP-seq
MIRT791758	hsa-miR-4492	CLIP-seq
MIRT791759	hsa-miR-4498	CLIP-seq
MIRT1933604	hsa-miR-4633-3p	CLIP-seq
MIRT1933605	hsa-miR-4640-5p	CLIP-seq
MIRT1933606	hsa-miR-4708-3p	CLIP-seq
MIRT1933607	hsa-miR-4710	CLIP-seq
MIRT1933608	hsa-miR-4726-5p	CLIP-seq
MIRT1933609	hsa-miR-4761-5p	CLIP-seq
MIRT791787	hsa-miR-762	CLIP-seq
MIRT791723	hsa-miR-1207-5p	CLIP-seq
MIRT2173666	hsa-miR-1321	CLIP-seq
MIRT2173667	hsa-miR-3192	CLIP-seq
MIRT2173668	hsa-miR-3689a-3p	CLIP-seq
MIRT2173669	hsa-miR-3689c	CLIP-seq
MIRT2173670	hsa-miR-370	CLIP-seq
MIRT2173671	hsa-miR-4419a	CLIP-seq
MIRT2173672	hsa-miR-4510	CLIP-seq
MIRT2173673	hsa-miR-4728-5p	CLIP-seq
MIRT791772	hsa-miR-4731-5p	CLIP-seq
MIRT2173674	hsa-miR-4739	CLIP-seq
MIRT2173675	hsa-miR-4756-5p	CLIP-seq
MIRT791776	hsa-miR-4763-3p	CLIP-seq
MIRT2173676	hsa-miR-670	CLIP-seq
MIRT2384348	hsa-miR-1203	CLIP-seq
MIRT2443847	hsa-miR-1184	CLIP-seq
MIRT791721	hsa-miR-1205	CLIP-seq
MIRT2443848	hsa-miR-1909	CLIP-seq
MIRT2443849	hsa-miR-3158-5p	CLIP-seq
MIRT2443850	hsa-miR-361-3p	CLIP-seq
MIRT2443851	hsa-miR-4281	CLIP-seq
MIRT2443852	hsa-miR-4446-3p	CLIP-seq
MIRT791758	hsa-miR-4492	CLIP-seq
MIRT791759	hsa-miR-4498	CLIP-seq
MIRT2443853	hsa-miR-4527	CLIP-seq
MIRT791787	hsa-miR-762	CLIP-seq

Show/Hide all(41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0003729	Function	MRNA binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	21834987
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	21834987
GO:0005938	Component	Cell cortex	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0007010	Process	Cytoskeleton organization	IBA	21873635
GO:0007010	Process	Cytoskeleton organization	IMP	21834987
GO:0007492	Process	Endoderm development	IEA
GO:0007612	Process	Learning	IEA
GO:0007616	Process	Long-term memory	ISS
GO:0007616	Process	Long-term memory	TAS	15537891
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0015629	Component	Actin cytoskeleton	IBA	21873635
GO:0016477	Process	Cell migration	IMP	21834987
GO:0022604	Process	Regulation of cell morphogenesis	IMP	21834987
GO:0031901	Component	Early endosome membrane	IEA
GO:0043025	Component	Neuronal cell body	TAS	15537891
GO:0043197	Component	Dendritic spine	ISS
GO:0045121	Component	Membrane raft	ISS
GO:0048168	Process	Regulation of neuronal synaptic plasticity	IBA	21873635
GO:0050804	Process	Modulation of chemical synaptic transmission	ISS
GO:0051028	Process	MRNA transport	ISS
GO:0051260	Process	Protein homooligomerization	ISS
GO:0060291	Process	Long-term synaptic potentiation	TAS	15537891
GO:0060997	Process	Dendritic spine morphogenesis	TAS	15537891
GO:0061001	Process	Regulation of dendritic spine morphogenesis	ISS
GO:0071598	Component	Neuronal ribonucleoprotein granule	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098845	Component	Postsynaptic endosome	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099149	Process	Regulation of postsynaptic neurotransmitter receptor internalization	IEA
GO:0110077	Process	Vesicle-mediated intercellular transport	ISS
GO:1900271	Process	Regulation of long-term synaptic potentiation	IBA	21873635
GO:1900271	Process	Regulation of long-term synaptic potentiation	ISS
GO:1900452	Process	Regulation of long-term synaptic depression	ISS
GO:1903561	Component	Extracellular vesicle	ISS
GO:2000969	Process	Positive regulation of AMPA receptor activity	IBA	21873635

MIM	HGNC	e!Ensembl
612461	648	ENSG00000198576

Protein

UniProt ID

Q7LC44

Protein name

Activity-regulated cytoskeleton-associated protein (hArc) (Activity-regulated gene 3.1 protein homolog) (ARC/ARG3.1) (Arg3.1)

Protein function

Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate

PDB

6TN7 , 6TNQ , 6TQ0 , 6YTU , 7R1Z , 7R23 , 8QF4 , 8QF5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18162	Arc_C	278 → 360	Arc C-lobe	Domain

Sequence

MELDHRTSGGLHAYPGPRGGQVAKPNVILQIGKCRAEMLEHVRRTHRHLLAEVSKQVERE
LKGLHRSVGKLESNLDGYVPTSDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVF
YRLERWADRLESTGGKYPVGSESARHTVSVGVGGPESYCHEADGYDYTVSPYAITPPPAA
GELPGQEPAEAQQYQPWVPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQVGGSEEYWLS
QIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRELDLPQKQGEPLDQ
FLWRKRDLYQTLYVDADEEEIIQYVVGTLQPKLKRFLRHPLPKTLEQLIQRGMEVQDDLE
QAAEPAGPHLPVEDEAETLTPAPNSESVASDRTQPE

Sequence length

396

Interactions

View interactions

	KEGG		Reactome
	Amphetamine addiction		NGF-stimulated transcription

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	18503570
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22083728

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Movement disorders	Movement Disorders		20298714
Senile dementia	Presenile dementia, Acute Confusional Senile Dementia		18503570
Status marmoratus	Etat Marbre		20298714

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