PLCL2 (phospholipase C like 2)

Gene

• Entrez ID: 23228
• Gene name: Phospholipase C like 2
• Gene symbol: PLCL2
• Synonyms: PLCE2
• Chromosome: 3
• Chromosome location: 3p24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025184	hsa-miR-181a-5p	Microarray	17612493
MIRT2595190	hsa-miR-1910	CLIP-seq
MIRT2595191	hsa-miR-1912	CLIP-seq
MIRT2595192	hsa-miR-25	CLIP-seq
MIRT2595193	hsa-miR-3128	CLIP-seq
MIRT2595194	hsa-miR-3157-5p	CLIP-seq
MIRT2595195	hsa-miR-32	CLIP-seq
MIRT2595196	hsa-miR-363	CLIP-seq
MIRT2595197	hsa-miR-367	CLIP-seq
MIRT2595198	hsa-miR-4270	CLIP-seq
MIRT2595199	hsa-miR-4279	CLIP-seq
MIRT2595200	hsa-miR-4300	CLIP-seq
MIRT2595201	hsa-miR-4304	CLIP-seq
MIRT2595202	hsa-miR-4441	CLIP-seq
MIRT2595203	hsa-miR-4522	CLIP-seq
MIRT2595204	hsa-miR-455-3p	CLIP-seq
MIRT2595205	hsa-miR-4691-3p	CLIP-seq
MIRT2595206	hsa-miR-4715-3p	CLIP-seq
MIRT2595207	hsa-miR-4720-5p	CLIP-seq
MIRT2595208	hsa-miR-4799-3p	CLIP-seq
MIRT2595209	hsa-miR-515-5p	CLIP-seq
MIRT2595210	hsa-miR-760	CLIP-seq
MIRT2595211	hsa-miR-920	CLIP-seq
MIRT2595212	hsa-miR-92a	CLIP-seq
MIRT2595213	hsa-miR-92b	CLIP-seq
MIRT2595190	hsa-miR-1910	CLIP-seq
MIRT2595194	hsa-miR-3157-5p	CLIP-seq
MIRT2595198	hsa-miR-4270	CLIP-seq
MIRT2595200	hsa-miR-4300	CLIP-seq
MIRT2595201	hsa-miR-4304	CLIP-seq
MIRT2595202	hsa-miR-4441	CLIP-seq
MIRT2595204	hsa-miR-455-3p	CLIP-seq
MIRT2595205	hsa-miR-4691-3p	CLIP-seq
MIRT2595211	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002322	Process	B cell proliferation involved in immune response	IEA
GO:0002337	Process	B-1a B cell differentiation	IEA
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IEA
GO:0032228	Process	Regulation of synaptic transmission, GABAergic	IEA
GO:0033135	Process	Regulation of peptidyl-serine phosphorylation	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0050811	Function	GABA receptor binding	IDA	16754670
GO:0050859	Process	Negative regulation of B cell receptor signaling pathway	IEA
GO:0070679	Function	Inositol 1,4,5 trisphosphate binding	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	26706316
GO:1900122	Process	Positive regulation of receptor binding	IEA

Other IDs

• MIM: 614276
• HGNC: 9064
• e!Ensembl: ENSG00000154822

Protein

• UniProt ID: Q9UPR0
• Protein name: Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)
• Protein function: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16457	PH_12	135 → 251	Pleckstrin homology domain	Domain
  PF09279	EF-hand_like	334 → 419	Phosphoinositide-specific phospholipase C, efhand-like	Domain
  PF00388	PI-PLC-X	428 → 571	Phosphatidylinositol-specific phospholipase C, X domain	Family
  PF00387	PI-PLC-Y	618 → 732	Phosphatidylinositol-specific phospholipase C, Y domain	Family
  PF00168	C2	754 → 862	C2 domain	Domain

• Sequence:

  MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS
  LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK
  TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD
  SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN
  IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN
  PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT
  KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE
  HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN
  EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG
  DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN
  MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN
  PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ
  NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD
  PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE
  FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK
  KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM
  LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA
  VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE
  TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE

• Sequence length: 1127

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Myocardial infarction	Myocardial Infarction	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	24916648
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	25939698
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	24390342, 30423114
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21822266, 31374203

Unknown
Disease name	Disease term	dbSNP ID	References
Biliary cirrhosis	Biliary cirrhosis, Primary biliary cirrhosis		21399635, 21399635, 26394269
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	29942085
Mood disorder	Mood Disorders		29942085
Psoriasis vulgaris	Psoriasis vulgaris		26626624