CYFIP1 (cytoplasmic FMR1 interacting protein 1)

Gene

• Entrez ID: 23191
• Gene name: Cytoplasmic FMR1 interacting protein 1
• Gene symbol: CYFIP1
• Synonyms: P140SRA-1, SHYC, SRA-1, SRA1
• Chromosome: 15
• Chromosome location: 15q11.2
• Summary: This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental re

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020537	hsa-miR-155-5p	Proteomics	18668040
MIRT045329	hsa-miR-185-5p	CLASH	23622248
MIRT042272	hsa-miR-484	CLASH	23622248
MIRT041300	hsa-miR-193b-3p	CLASH	23622248
MIRT920158	hsa-miR-214	CLIP-seq
MIRT920159	hsa-miR-3619-5p	CLIP-seq
MIRT920160	hsa-miR-4291	CLIP-seq
MIRT920161	hsa-miR-761	CLIP-seq
MIRT920162	hsa-miR-922	CLIP-seq
MIRT920163	hsa-miR-1178	CLIP-seq
MIRT920164	hsa-miR-1243	CLIP-seq
MIRT920165	hsa-miR-1290	CLIP-seq
MIRT920166	hsa-miR-1292	CLIP-seq
MIRT920167	hsa-miR-2964a-5p	CLIP-seq
MIRT920168	hsa-miR-31	CLIP-seq
MIRT920169	hsa-miR-3128	CLIP-seq
MIRT920170	hsa-miR-3167	CLIP-seq
MIRT920171	hsa-miR-3613-3p	CLIP-seq
MIRT920172	hsa-miR-4471	CLIP-seq
MIRT920173	hsa-miR-4502	CLIP-seq
MIRT920174	hsa-miR-4760-5p	CLIP-seq
MIRT920175	hsa-miR-4766-5p	CLIP-seq
MIRT920176	hsa-miR-494	CLIP-seq
MIRT920177	hsa-miR-569	CLIP-seq
MIRT920178	hsa-miR-582-3p	CLIP-seq
MIRT920179	hsa-miR-582-5p	CLIP-seq
MIRT920180	hsa-miR-876-5p	CLIP-seq
MIRT1972711	hsa-miR-590-3p	CLIP-seq
MIRT2208310	hsa-miR-1	CLIP-seq
MIRT2208311	hsa-miR-103a	CLIP-seq
MIRT2208312	hsa-miR-107	CLIP-seq
MIRT920164	hsa-miR-1243	CLIP-seq
MIRT920165	hsa-miR-1290	CLIP-seq
MIRT2208313	hsa-miR-15a	CLIP-seq
MIRT2208314	hsa-miR-15b	CLIP-seq
MIRT2208315	hsa-miR-16	CLIP-seq
MIRT2208316	hsa-miR-185	CLIP-seq
MIRT2208317	hsa-miR-1909	CLIP-seq
MIRT2208318	hsa-miR-195	CLIP-seq
MIRT2208319	hsa-miR-206	CLIP-seq
MIRT2208320	hsa-miR-216a	CLIP-seq
MIRT2208321	hsa-miR-22	CLIP-seq
MIRT920167	hsa-miR-2964a-5p	CLIP-seq
MIRT2208322	hsa-miR-300	CLIP-seq
MIRT2208323	hsa-miR-3121-3p	CLIP-seq
MIRT920170	hsa-miR-3167	CLIP-seq
MIRT2208324	hsa-miR-3190	CLIP-seq
MIRT2208325	hsa-miR-3591-5p	CLIP-seq
MIRT2208326	hsa-miR-3673	CLIP-seq
MIRT2208327	hsa-miR-3681	CLIP-seq
MIRT2208328	hsa-miR-3688-3p	CLIP-seq
MIRT2208329	hsa-miR-381	CLIP-seq
MIRT2208330	hsa-miR-3910	CLIP-seq
MIRT2208331	hsa-miR-424	CLIP-seq
MIRT2208332	hsa-miR-425	CLIP-seq
MIRT2208333	hsa-miR-4306	CLIP-seq
MIRT2208334	hsa-miR-4310	CLIP-seq
MIRT2208335	hsa-miR-4422	CLIP-seq
MIRT2208336	hsa-miR-4424	CLIP-seq
MIRT2208337	hsa-miR-4460	CLIP-seq
MIRT920173	hsa-miR-4502	CLIP-seq
MIRT2208338	hsa-miR-4530	CLIP-seq
MIRT2208339	hsa-miR-4644	CLIP-seq
MIRT2208340	hsa-miR-4659a-5p	CLIP-seq
MIRT2208341	hsa-miR-4659b-5p	CLIP-seq
MIRT2208342	hsa-miR-4666-3p	CLIP-seq
MIRT2208343	hsa-miR-4716-5p	CLIP-seq
MIRT2208344	hsa-miR-4727-3p	CLIP-seq
MIRT920174	hsa-miR-4760-5p	CLIP-seq
MIRT2208345	hsa-miR-4762-3p	CLIP-seq
MIRT920175	hsa-miR-4766-5p	CLIP-seq
MIRT2208346	hsa-miR-4788	CLIP-seq
MIRT920176	hsa-miR-494	CLIP-seq
MIRT2208347	hsa-miR-497	CLIP-seq
MIRT2208348	hsa-miR-548an	CLIP-seq
MIRT2208349	hsa-miR-548c-3p	CLIP-seq
MIRT920177	hsa-miR-569	CLIP-seq
MIRT920178	hsa-miR-582-3p	CLIP-seq
MIRT920179	hsa-miR-582-5p	CLIP-seq
MIRT1972711	hsa-miR-590-3p	CLIP-seq
MIRT2208350	hsa-miR-613	CLIP-seq
MIRT2208351	hsa-miR-642b	CLIP-seq
MIRT2208352	hsa-miR-671-5p	CLIP-seq
MIRT920180	hsa-miR-876-5p	CLIP-seq
MIRT920164	hsa-miR-1243	CLIP-seq
MIRT920165	hsa-miR-1290	CLIP-seq
MIRT920170	hsa-miR-3167	CLIP-seq
MIRT2208324	hsa-miR-3190	CLIP-seq
MIRT2208325	hsa-miR-3591-5p	CLIP-seq
MIRT2208327	hsa-miR-3681	CLIP-seq
MIRT2208337	hsa-miR-4460	CLIP-seq
MIRT2208344	hsa-miR-4727-3p	CLIP-seq
MIRT2208351	hsa-miR-642b	CLIP-seq
MIRT2208352	hsa-miR-671-5p	CLIP-seq
MIRT920180	hsa-miR-876-5p	CLIP-seq
MIRT920163	hsa-miR-1178	CLIP-seq
MIRT920166	hsa-miR-1292	CLIP-seq
MIRT2512090	hsa-miR-2114	CLIP-seq
MIRT920158	hsa-miR-214	CLIP-seq
MIRT2208320	hsa-miR-216a	CLIP-seq
MIRT2208321	hsa-miR-22	CLIP-seq
MIRT2208323	hsa-miR-3121-3p	CLIP-seq
MIRT2512091	hsa-miR-335	CLIP-seq
MIRT920171	hsa-miR-3613-3p	CLIP-seq
MIRT920159	hsa-miR-3619-5p	CLIP-seq
MIRT2512092	hsa-miR-3674	CLIP-seq
MIRT2512093	hsa-miR-3914	CLIP-seq
MIRT920160	hsa-miR-4291	CLIP-seq
MIRT2208335	hsa-miR-4422	CLIP-seq
MIRT920172	hsa-miR-4471	CLIP-seq
MIRT920176	hsa-miR-494	CLIP-seq
MIRT2512094	hsa-miR-513c	CLIP-seq
MIRT2512095	hsa-miR-514b-5p	CLIP-seq
MIRT2208349	hsa-miR-548c-3p	CLIP-seq
MIRT2208351	hsa-miR-642b	CLIP-seq
MIRT920161	hsa-miR-761	CLIP-seq
MIRT920162	hsa-miR-922	CLIP-seq
MIRT920163	hsa-miR-1178	CLIP-seq
MIRT920166	hsa-miR-1292	CLIP-seq
MIRT920158	hsa-miR-214	CLIP-seq
MIRT2208321	hsa-miR-22	CLIP-seq
MIRT2512091	hsa-miR-335	CLIP-seq
MIRT920171	hsa-miR-3613-3p	CLIP-seq
MIRT920159	hsa-miR-3619-5p	CLIP-seq
MIRT2512092	hsa-miR-3674	CLIP-seq
MIRT2512093	hsa-miR-3914	CLIP-seq
MIRT920160	hsa-miR-4291	CLIP-seq
MIRT920172	hsa-miR-4471	CLIP-seq
MIRT920176	hsa-miR-494	CLIP-seq
MIRT2512094	hsa-miR-513c	CLIP-seq
MIRT2512095	hsa-miR-514b-5p	CLIP-seq
MIRT2208351	hsa-miR-642b	CLIP-seq
MIRT920161	hsa-miR-761	CLIP-seq
MIRT920162	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000340	Function	RNA 7-methylguanosine cap binding	IBA	21873635
GO:0000902	Process	Cell morphogenesis	IBA	21873635
GO:0001726	Component	Ruffle	ISS
GO:0005515	Function	Protein binding	IPI	11438699, 15294869, 15296760, 16260607, 18805096, 19363480, 21107423, 24439377, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005845	Component	MRNA cap binding complex	ISS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006417	Process	Regulation of translation	IBA	21873635
GO:0007411	Process	Axon guidance	IBA	21873635
GO:0008360	Process	Regulation of cell shape	IEA
GO:0010592	Process	Positive regulation of lamellipodium assembly	IDA	21107423
GO:0016601	Process	Rac protein signal transduction	IMP	21107423
GO:0030027	Component	Lamellipodium	ISS
GO:0030031	Process	Cell projection assembly	IBA	21873635
GO:0030032	Process	Lamellipodium assembly	IBA	21873635
GO:0030032	Process	Lamellipodium assembly	ISS
GO:0031209	Component	SCAR complex	IBA	21873635
GO:0031209	Component	SCAR complex	IMP	21107423
GO:0031267	Function	Small GTPase binding	IMP	21107423
GO:0031267	Function	Small GTPase binding	ISS
GO:0031529	Process	Ruffle organization	ISS
GO:0031641	Process	Regulation of myelination	IEA
GO:0032433	Component	Filopodium tip	IEA
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0035580	Component	Specific granule lumen	TAS
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043005	Component	Neuron projection	ISS
GO:0043025	Component	Neuronal cell body	IEA
GO:0043195	Component	Terminal bouton	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0044294	Component	Dendritic growth cone	IEA
GO:0044295	Component	Axonal growth cone	IEA
GO:0045182	Function	Translation regulator activity	IEA
GO:0045202	Component	Synapse	IBA	21873635
GO:0045773	Process	Positive regulation of axon extension	IEA
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	TAS
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0048675	Process	Axon extension	IMP	16260607
GO:0050890	Process	Cognition	IMP	17519220
GO:0051015	Function	Actin filament binding	ISS
GO:0051388	Process	Positive regulation of neurotrophin TRK receptor signaling pathway	IEA
GO:0051602	Process	Response to electrical stimulus	IEA
GO:0060076	Component	Excitatory synapse	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0090724	Component	Central region of growth cone	IEA
GO:0090725	Component	Peripheral region of growth cone	IEA
GO:0097484	Process	Dendrite extension	IEA
GO:0099563	Process	Modification of synaptic structure	IBA	21873635
GO:0099578	Process	Regulation of translation at postsynapse, modulating synaptic transmission	IEA
GO:1900006	Process	Positive regulation of dendrite development	IEA
GO:1900029	Process	Positive regulation of ruffle assembly	IEA
GO:1903422	Process	Negative regulation of synaptic vesicle recycling	IEA
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1905274	Process	Regulation of modification of postsynaptic actin cytoskeleton	IEA
GO:2000601	Process	Positive regulation of Arp2/3 complex-mediated actin nucleation	IMP	21107423

Other IDs

• MIM: 606322
• HGNC: 13759
• e!Ensembl: ENSG00000273749

Protein

• UniProt ID: Q7L576
• Protein name: Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)
• Protein function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR
• PDB: 3P8C, 4N78, 7USC, 7USD, 7USE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07159	DUF1394	59 → 303	Protein of unknown function (DUF1394)	Family
  PF05994	FragX_IP	389 → 1222	Cytoplasmic Fragile-X interacting family	Family

• Sequence:

  MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYI
  EQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVT
  KLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCS
  VKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLAD
  IVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFK
  QLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFI
  SELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPT
  DKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTV
  YAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPK
  SGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESF
  FYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASM
  MEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGS
  LLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSL
  ELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRIT
  LHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSS
  IYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC
  RLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVC
  DLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDL
  LTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCI
  PVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVP
  LKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS

• Sequence length: 1253

Pathways

KEGG:

Regulation of actin cytoskeleton
Pathogenic Escherichia coli infection
Salmonella infection

Reactome:

Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation
FCGR3A-mediated phagocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24996170