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UBXN4 (UBX domain protein 4)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23190
Gene nameGene Name - the full gene name approved by the HGNC.
UBX domain protein 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
UBXN4
SynonymsGene synonyms aliases
UBXD2, UBXDC1, erasin
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q21.3
SummarySummary of gene provided in NCBI Entrez Gene.
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT085307 hsa-miR-92a-3p PAR-CLIP 20371350
MIRT085309 hsa-miR-367-3p PAR-CLIP 20371350
MIRT085310 hsa-miR-92b-3p PAR-CLIP 20371350
MIRT085306 hsa-miR-32-5p PAR-CLIP 20371350
MIRT085305 hsa-miR-25-3p PAR-CLIP 20371350
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18775313, 19822669, 22119785, 25416956, 29997244, 32296183
GO:0005635 Component Nuclear envelope IEA
GO:0005783 Component Endoplasmic reticulum IDA
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0005829 Component Cytosol IDA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q92575
Protein name UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)
Protein function Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).
PDB 2KXJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00789 UBX
314 395
UBX domain
Domain
Sequence
MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDT
KSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETS
VANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSS
QEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKR
KQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLA
KQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNF
SLATMFPRREFTKEDYKKKLLDLELAPSASVVLLP
AGRPTASIVHSSSGDIWTLLGTVLY
PFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKK
EGKIYRLRTQDDGEDENNTWNGNSTQQM
Sequence length 508
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  Protein processing in endoplasmic reticulum  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Keratoconus Keratoconus rs273585637, rs273585632, rs273585616, rs273585618, rs281865144, rs281865150, rs1553500862, rs756938019 21979947

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