PHLDB1 (pleckstrin homology like domain family B member 1)

Gene

• Entrez ID: 23187
• Gene name: Pleckstrin homology like domain family B member 1
• Gene symbol: PHLDB1
• Synonyms: LL5A, LL5alpha, OI23
• Chromosome: 11
• Chromosome location: 11q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040852	hsa-miR-18a-3p	CLASH	23622248
MIRT1232074	hsa-miR-296-5p	CLIP-seq
MIRT1232075	hsa-miR-4437	CLIP-seq
MIRT1232076	hsa-miR-4645-5p	CLIP-seq
MIRT1232077	hsa-miR-4673	CLIP-seq
MIRT1232078	hsa-miR-4742-5p	CLIP-seq
MIRT1232079	hsa-miR-661	CLIP-seq
MIRT1232080	hsa-miR-200b	CLIP-seq
MIRT1232081	hsa-miR-200c	CLIP-seq
MIRT1232082	hsa-miR-203	CLIP-seq
MIRT1232083	hsa-miR-3128	CLIP-seq
MIRT1232084	hsa-miR-3153	CLIP-seq
MIRT1232085	hsa-miR-3160-3p	CLIP-seq
MIRT1232086	hsa-miR-331-3p	CLIP-seq
MIRT1232087	hsa-miR-3665	CLIP-seq
MIRT1232088	hsa-miR-3934	CLIP-seq
MIRT1232089	hsa-miR-3936	CLIP-seq
MIRT1232090	hsa-miR-4273	CLIP-seq
MIRT1232091	hsa-miR-429	CLIP-seq
MIRT1232092	hsa-miR-4428	CLIP-seq
MIRT1232093	hsa-miR-4470	CLIP-seq
MIRT1232094	hsa-miR-4475	CLIP-seq
MIRT1232095	hsa-miR-4649-3p	CLIP-seq
MIRT1232096	hsa-miR-4677-5p	CLIP-seq
MIRT1232097	hsa-miR-4724-5p	CLIP-seq
MIRT1232098	hsa-miR-520d-5p	CLIP-seq
MIRT1232099	hsa-miR-524-5p	CLIP-seq
MIRT1232100	hsa-miR-548l	CLIP-seq
MIRT1232101	hsa-miR-548n	CLIP-seq
MIRT2068111	hsa-miR-4656	CLIP-seq
MIRT2068112	hsa-miR-4731-5p	CLIP-seq
MIRT2068113	hsa-miR-136	CLIP-seq
MIRT2068114	hsa-miR-143	CLIP-seq
MIRT2068115	hsa-miR-3135b	CLIP-seq
MIRT2068116	hsa-miR-4770	CLIP-seq
MIRT2295465	hsa-miR-3145-5p	CLIP-seq
MIRT2593100	hsa-miR-1291	CLIP-seq
MIRT2593101	hsa-miR-1909	CLIP-seq
MIRT2593102	hsa-miR-2278	CLIP-seq
MIRT1232074	hsa-miR-296-5p	CLIP-seq
MIRT2593103	hsa-miR-3117-5p	CLIP-seq
MIRT1232084	hsa-miR-3153	CLIP-seq
MIRT2593104	hsa-miR-3176	CLIP-seq
MIRT2593105	hsa-miR-3179	CLIP-seq
MIRT2593106	hsa-miR-326	CLIP-seq
MIRT2593107	hsa-miR-328	CLIP-seq
MIRT2593108	hsa-miR-330-5p	CLIP-seq
MIRT2593109	hsa-miR-3591-5p	CLIP-seq
MIRT2593110	hsa-miR-361-3p	CLIP-seq
MIRT2593111	hsa-miR-3689d	CLIP-seq
MIRT2593112	hsa-miR-3922-3p	CLIP-seq
MIRT2593113	hsa-miR-4255	CLIP-seq
MIRT2593114	hsa-miR-4417	CLIP-seq
MIRT1232092	hsa-miR-4428	CLIP-seq
MIRT1232075	hsa-miR-4437	CLIP-seq
MIRT1232094	hsa-miR-4475	CLIP-seq
MIRT2593115	hsa-miR-4533	CLIP-seq
MIRT1232076	hsa-miR-4645-5p	CLIP-seq
MIRT2593116	hsa-miR-4646-5p	CLIP-seq
MIRT2593117	hsa-miR-4649-5p	CLIP-seq
MIRT1232077	hsa-miR-4673	CLIP-seq
MIRT2068112	hsa-miR-4731-5p	CLIP-seq
MIRT1232078	hsa-miR-4742-5p	CLIP-seq
MIRT2593118	hsa-miR-4747-5p	CLIP-seq
MIRT2593119	hsa-miR-4780	CLIP-seq
MIRT2593120	hsa-miR-524-3p	CLIP-seq
MIRT2593121	hsa-miR-525-3p	CLIP-seq
MIRT2593122	hsa-miR-541	CLIP-seq
MIRT2593123	hsa-miR-548ag	CLIP-seq
MIRT2593124	hsa-miR-548ai	CLIP-seq
MIRT1232100	hsa-miR-548l	CLIP-seq
MIRT1232101	hsa-miR-548n	CLIP-seq
MIRT2593125	hsa-miR-570	CLIP-seq
MIRT2593126	hsa-miR-654-5p	CLIP-seq
MIRT1232079	hsa-miR-661	CLIP-seq
MIRT2687848	hsa-miR-1207-3p	CLIP-seq
MIRT2593100	hsa-miR-1291	CLIP-seq
MIRT2593101	hsa-miR-1909	CLIP-seq
MIRT2593102	hsa-miR-2278	CLIP-seq
MIRT1232074	hsa-miR-296-5p	CLIP-seq
MIRT2593103	hsa-miR-3117-5p	CLIP-seq
MIRT2068115	hsa-miR-3135b	CLIP-seq
MIRT2593104	hsa-miR-3176	CLIP-seq
MIRT2593106	hsa-miR-326	CLIP-seq
MIRT2593107	hsa-miR-328	CLIP-seq
MIRT2593108	hsa-miR-330-5p	CLIP-seq
MIRT2593109	hsa-miR-3591-5p	CLIP-seq
MIRT2687849	hsa-miR-3612	CLIP-seq
MIRT2593110	hsa-miR-361-3p	CLIP-seq
MIRT2593111	hsa-miR-3689d	CLIP-seq
MIRT2593112	hsa-miR-3922-3p	CLIP-seq
MIRT2593113	hsa-miR-4255	CLIP-seq
MIRT2593114	hsa-miR-4417	CLIP-seq
MIRT1232092	hsa-miR-4428	CLIP-seq
MIRT1232075	hsa-miR-4437	CLIP-seq
MIRT2687850	hsa-miR-4443	CLIP-seq
MIRT2593115	hsa-miR-4533	CLIP-seq
MIRT1232076	hsa-miR-4645-5p	CLIP-seq
MIRT2593116	hsa-miR-4646-5p	CLIP-seq
MIRT1232077	hsa-miR-4673	CLIP-seq
MIRT2687851	hsa-miR-4691-5p	CLIP-seq
MIRT2068112	hsa-miR-4731-5p	CLIP-seq
MIRT1232078	hsa-miR-4742-5p	CLIP-seq
MIRT2593118	hsa-miR-4747-5p	CLIP-seq
MIRT2593119	hsa-miR-4780	CLIP-seq
MIRT2593120	hsa-miR-524-3p	CLIP-seq
MIRT2593121	hsa-miR-525-3p	CLIP-seq
MIRT2593122	hsa-miR-541	CLIP-seq
MIRT2593125	hsa-miR-570	CLIP-seq
MIRT2687852	hsa-miR-650	CLIP-seq
MIRT2593126	hsa-miR-654-5p	CLIP-seq
MIRT1232079	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0010470	Process	Regulation of gastrulation	IMP	23940118
GO:0010717	Process	Regulation of epithelial to mesenchymal transition	IMP	23940118
GO:0045180	Component	Basal cortex	IBA	21873635
GO:0045180	Component	Basal cortex	IDA	23940118
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IBA	21873635
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IGI	23940118
GO:1904261	Process	Positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IGI	23940118
GO:1904261	Process	Positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IMP	23940118

Other IDs

• MIM: 612834
• HGNC: 23697
• e!Ensembl: ENSG00000019144

Protein

• UniProt ID: Q86UU1
• Protein name: Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	1257 → 1369	PH domain	Domain

• Sequence:

  MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLE
  EGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYPCGNACTIDGLPVRQPTRLTQGC
  MLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSPVPAESESLVNGNHTPQTATRGP
  SACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPG
  AMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQ
  SRPSGARSESPRLSRKGGHERPPSPGLRGLLTDSPAATVLAEARRATESPRLGGQLPVVA
  ISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGTLQDRPPSPFREPPGSERVLTTSP
  SRQLVGRTFSDGLATRTLQPPESPRLGRRGLDSMRELPPLSPSLSRRALSPLPTRTTPDP
  KLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHKGSFSGRLSP
  AYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDLLEYHRRQRQER
  LREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATAALALAGRRPSRGLAGA
  SGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKLQGEVLALEEER
  AQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVDQLQEKL
  VALETGIQKERDKEAEALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRS
  IAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGG
  RPFPKTTSTLKEMEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKASRQLQV
  YRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNGTGSLPR
  NLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAAPFPAGP
  SGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSPDNMSSA
  SGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQALEEERRRREQVERRLQSESAR
  RQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCR
  GYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAK
  KRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEGYTQFMN

• Sequence length: 1377

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	19578367, 21531791, 29743610, 30714141, 26424050, 28346443, 19578367
Nasopharyngeal carcinoma	Nasopharyngeal carcinoma	rs200046052	20512145

Unknown
Disease name	Disease term	dbSNP ID	References
Celiac disease	Celiac Disease	rs2305764, rs35218876	25920553
Central nervous system neoplasms	Central Nervous System Neoplasms		19578367, 21531791, 28346443, 26424050
Sclerosing cholangitis	Primary sclerosing cholangitis		23603763