PASK (PAS domain containing serine/threonine kinase)

Gene

• Entrez ID: 23178
• Gene name: PAS domain containing serine/threonine kinase
• Gene symbol: PASK
• Synonyms: PASKIN, STK37
• Chromosome: 2
• Chromosome location: 2q37.3
• Summary: This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024926	hsa-miR-215-5p	Microarray	19074876
MIRT026483	hsa-miR-192-5p	Microarray	19074876
MIRT1214978	hsa-miR-18a	CLIP-seq
MIRT1214979	hsa-miR-18b	CLIP-seq
MIRT1214980	hsa-miR-4422	CLIP-seq
MIRT1214981	hsa-miR-4735-3p	CLIP-seq
MIRT1214982	hsa-miR-4775	CLIP-seq
MIRT1214978	hsa-miR-18a	CLIP-seq
MIRT1214979	hsa-miR-18b	CLIP-seq
MIRT1214980	hsa-miR-4422	CLIP-seq
MIRT1214981	hsa-miR-4735-3p	CLIP-seq
MIRT1214982	hsa-miR-4775	CLIP-seq
MIRT1214978	hsa-miR-18a	CLIP-seq
MIRT1214979	hsa-miR-18b	CLIP-seq
MIRT1214980	hsa-miR-4422	CLIP-seq
MIRT1214981	hsa-miR-4735-3p	CLIP-seq
MIRT1214982	hsa-miR-4775	CLIP-seq
MIRT1214978	hsa-miR-18a	CLIP-seq
MIRT1214979	hsa-miR-18b	CLIP-seq
MIRT1214980	hsa-miR-4422	CLIP-seq
MIRT1214981	hsa-miR-4735-3p	CLIP-seq
MIRT1214982	hsa-miR-4775	CLIP-seq
MIRT1214978	hsa-miR-18a	CLIP-seq
MIRT1214979	hsa-miR-18b	CLIP-seq
MIRT1214980	hsa-miR-4422	CLIP-seq
MIRT1214981	hsa-miR-4735-3p	CLIP-seq
MIRT1214982	hsa-miR-4775	CLIP-seq
MIRT2290257	hsa-miR-1	CLIP-seq
MIRT2290258	hsa-miR-141	CLIP-seq
MIRT1214978	hsa-miR-18a	CLIP-seq
MIRT1214979	hsa-miR-18b	CLIP-seq
MIRT2290259	hsa-miR-200a	CLIP-seq
MIRT2290260	hsa-miR-206	CLIP-seq
MIRT2290261	hsa-miR-3673	CLIP-seq
MIRT2290262	hsa-miR-4307	CLIP-seq
MIRT1214980	hsa-miR-4422	CLIP-seq
MIRT1214981	hsa-miR-4735-3p	CLIP-seq
MIRT1214982	hsa-miR-4775	CLIP-seq
MIRT2290263	hsa-miR-613	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	16275910, 17595531, 20943661, 21418524
GO:0005515	Function	Protein binding	IPI	16275910, 17595531, 21418524
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	17595531
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	17595531
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IDA	16275910
GO:0035091	Function	Phosphatidylinositol binding	IDA	21418524
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0043576	Process	Regulation of respiratory gaseous exchange	ISS
GO:0045719	Process	Negative regulation of glycogen biosynthetic process	IBA	21873635
GO:0045719	Process	Negative regulation of glycogen biosynthetic process	IDA	16275910
GO:0045727	Process	Positive regulation of translation	TAS	17595531
GO:0046777	Process	Protein autophosphorylation	IDA	20943661, 21418524
GO:0070092	Process	Regulation of glucagon secretion	ISS
GO:0097009	Process	Energy homeostasis	ISS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 607505
• HGNC: 17270
• e!Ensembl: ENSG00000115687

Protein

• UniProt ID: Q96RG2
• Protein name: PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)
• Protein function: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under sta
• PDB: 1LL8, 3DLS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13426	PAS_9	131 → 233	PAS domain	Domain
  PF13426	PAS_9	345 → 414	PAS domain	Domain
  PF00069	Pkinase	999 → 1251	Protein kinase domain	Domain

• Sequence:

  MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
  RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
  PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
  ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
  WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
  GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
  NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
  TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
  LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
  KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
  LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
  LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
  DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
  VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
  RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
  RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
  LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
  KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
  MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF
  TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE
  NPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADY
  TWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRL
  LTS

• Sequence length: 1323

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
2q37 deletion syndrome	Chromosome 2q37 deletion syndrome	rs748900140, rs1064797002	19365831
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	19365831

Unknown
Disease name	Disease term	dbSNP ID	References
Metastatic melanoma	Metastatic melanoma