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DCUN1D4 (defective in cullin neddylation 1 domain containing 4)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23142
Gene nameGene Name - the full gene name approved by the HGNC.
Defective in cullin neddylation 1 domain containing 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
DCUN1D4
SynonymsGene synonyms aliases
DCNL4
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q12
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019951 hsa-miR-375 Microarray 20215506
MIRT050924 hsa-miR-17-5p CLASH 23622248
MIRT164842 hsa-miR-27a-3p HITS-CLIP 22473208
MIRT164846 hsa-miR-27b-3p HITS-CLIP 22473208
MIRT927926 hsa-miR-1179 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IBA 21873635
GO:0005515 Function Protein binding IPI 21911577, 23201271, 26906416
GO:0005634 Component Nucleus IDA
GO:0005634 Component Nucleus IMP 26906416
GO:0031624 Function Ubiquitin conjugating enzyme binding IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q92564
Protein name DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)
Protein function Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin
PDB 5V89
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03556 Cullin_binding
175 285
Cullin binding
Family
Sequence
MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKV
MPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVV
GPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTL
DYLRSFLNDSTNFKLIYRYAFDFAREKDQRSLDINTAKCMLGLLLGKIWPLFPVFHQFLE
QSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEW
YKDKQMS
Sequence length 292
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Neddylation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lung carcinoma Squamous cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 29924316

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