ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1)

Gene

• Entrez ID: 23140
• Gene name: Zinc finger ZZ-type and EF-hand domain containing 1
• Gene symbol: ZZEF1
• Synonyms: ZZZ4
• Chromosome: 17
• Chromosome location: 17p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051207	hsa-miR-16-5p	CLASH	23622248
MIRT045740	hsa-miR-125a-5p	CLASH	23622248
MIRT042030	hsa-miR-484	CLASH	23622248
MIRT040251	hsa-miR-615-3p	CLASH	23622248
MIRT439172	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439172	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1544932	hsa-miR-122	CLIP-seq
MIRT1544933	hsa-miR-1243	CLIP-seq
MIRT1544934	hsa-miR-1245b-5p	CLIP-seq
MIRT1544935	hsa-miR-149	CLIP-seq
MIRT1544936	hsa-miR-15a	CLIP-seq
MIRT1544937	hsa-miR-15b	CLIP-seq
MIRT1544938	hsa-miR-16	CLIP-seq
MIRT1544939	hsa-miR-1914	CLIP-seq
MIRT1544940	hsa-miR-195	CLIP-seq
MIRT1544941	hsa-miR-1972	CLIP-seq
MIRT1544942	hsa-miR-2110	CLIP-seq
MIRT1544943	hsa-miR-296-5p	CLIP-seq
MIRT1544944	hsa-miR-3064-5p	CLIP-seq
MIRT1544945	hsa-miR-3065-3p	CLIP-seq
MIRT1544946	hsa-miR-3074-5p	CLIP-seq
MIRT1544947	hsa-miR-3127-3p	CLIP-seq
MIRT1544948	hsa-miR-3142	CLIP-seq
MIRT1544949	hsa-miR-3150a-3p	CLIP-seq
MIRT1544950	hsa-miR-3151	CLIP-seq
MIRT1544951	hsa-miR-3184	CLIP-seq
MIRT1544952	hsa-miR-326	CLIP-seq
MIRT1544953	hsa-miR-330-5p	CLIP-seq
MIRT1544954	hsa-miR-3545-5p	CLIP-seq
MIRT1544955	hsa-miR-3654	CLIP-seq
MIRT1544956	hsa-miR-3692	CLIP-seq
MIRT1544957	hsa-miR-3914	CLIP-seq
MIRT1544958	hsa-miR-3977	CLIP-seq
MIRT1544959	hsa-miR-423-5p	CLIP-seq
MIRT1544960	hsa-miR-424	CLIP-seq
MIRT1544961	hsa-miR-4266	CLIP-seq
MIRT1544962	hsa-miR-4283	CLIP-seq
MIRT1544963	hsa-miR-4328	CLIP-seq
MIRT1544964	hsa-miR-4428	CLIP-seq
MIRT1544965	hsa-miR-4432	CLIP-seq
MIRT1544966	hsa-miR-4450	CLIP-seq
MIRT1544967	hsa-miR-4456	CLIP-seq
MIRT1544968	hsa-miR-4530	CLIP-seq
MIRT1544969	hsa-miR-4650-5p	CLIP-seq
MIRT1544970	hsa-miR-4677-3p	CLIP-seq
MIRT1544971	hsa-miR-4695-5p	CLIP-seq
MIRT1544972	hsa-miR-4755-3p	CLIP-seq
MIRT1544973	hsa-miR-4779	CLIP-seq
MIRT1544974	hsa-miR-4794	CLIP-seq
MIRT1544975	hsa-miR-497	CLIP-seq
MIRT1544976	hsa-miR-499-5p	CLIP-seq
MIRT1544977	hsa-miR-499a-5p	CLIP-seq
MIRT1544978	hsa-miR-541	CLIP-seq
MIRT1544979	hsa-miR-654-5p	CLIP-seq
MIRT1544980	hsa-miR-659	CLIP-seq
MIRT1544981	hsa-miR-760	CLIP-seq
MIRT1544982	hsa-miR-873	CLIP-seq
MIRT1544983	hsa-miR-942	CLIP-seq
MIRT2164576	hsa-miR-1268	CLIP-seq
MIRT2164577	hsa-miR-1268b	CLIP-seq
MIRT2164578	hsa-miR-1282	CLIP-seq
MIRT2164579	hsa-miR-1285	CLIP-seq
MIRT2164580	hsa-miR-1293	CLIP-seq
MIRT2164581	hsa-miR-147	CLIP-seq
MIRT2164582	hsa-miR-153	CLIP-seq
MIRT2164583	hsa-miR-1912	CLIP-seq
MIRT2164584	hsa-miR-1913	CLIP-seq
MIRT2164585	hsa-miR-1915	CLIP-seq
MIRT1544942	hsa-miR-2110	CLIP-seq
MIRT2164586	hsa-miR-2115	CLIP-seq
MIRT2164587	hsa-miR-299-3p	CLIP-seq
MIRT2164588	hsa-miR-31	CLIP-seq
MIRT2164589	hsa-miR-3130-3p	CLIP-seq
MIRT1544949	hsa-miR-3150a-3p	CLIP-seq
MIRT2164590	hsa-miR-3158-5p	CLIP-seq
MIRT2164591	hsa-miR-3166	CLIP-seq
MIRT1544951	hsa-miR-3184	CLIP-seq
MIRT2164592	hsa-miR-3187-5p	CLIP-seq
MIRT2164593	hsa-miR-3194-3p	CLIP-seq
MIRT2164594	hsa-miR-324-3p	CLIP-seq
MIRT1544956	hsa-miR-3692	CLIP-seq
MIRT2164595	hsa-miR-3907	CLIP-seq
MIRT2164596	hsa-miR-3910	CLIP-seq
MIRT2164597	hsa-miR-3911	CLIP-seq
MIRT1544959	hsa-miR-423-5p	CLIP-seq
MIRT2164598	hsa-miR-425	CLIP-seq
MIRT2164599	hsa-miR-4252	CLIP-seq
MIRT1544961	hsa-miR-4266	CLIP-seq
MIRT2164600	hsa-miR-4303	CLIP-seq
MIRT2164601	hsa-miR-432	CLIP-seq
MIRT1544965	hsa-miR-4432	CLIP-seq
MIRT1544966	hsa-miR-4450	CLIP-seq
MIRT1544967	hsa-miR-4456	CLIP-seq
MIRT2164602	hsa-miR-448	CLIP-seq
MIRT2164603	hsa-miR-4483	CLIP-seq
MIRT2164604	hsa-miR-4484	CLIP-seq
MIRT2164605	hsa-miR-4491	CLIP-seq
MIRT2164606	hsa-miR-4505	CLIP-seq
MIRT2164607	hsa-miR-4509	CLIP-seq
MIRT2164608	hsa-miR-4648	CLIP-seq
MIRT2164609	hsa-miR-4657	CLIP-seq
MIRT2164610	hsa-miR-4665-3p	CLIP-seq
MIRT2164611	hsa-miR-4685-5p	CLIP-seq
MIRT2164612	hsa-miR-4691-3p	CLIP-seq
MIRT1544971	hsa-miR-4695-5p	CLIP-seq
MIRT2164613	hsa-miR-4696	CLIP-seq
MIRT2164614	hsa-miR-4726-3p	CLIP-seq
MIRT2164615	hsa-miR-4749-3p	CLIP-seq
MIRT2164616	hsa-miR-4771	CLIP-seq
MIRT1544973	hsa-miR-4779	CLIP-seq
MIRT1544976	hsa-miR-499-5p	CLIP-seq
MIRT2164617	hsa-miR-508-5p	CLIP-seq
MIRT1544978	hsa-miR-541	CLIP-seq
MIRT2164618	hsa-miR-548an	CLIP-seq
MIRT2164619	hsa-miR-612	CLIP-seq
MIRT2164620	hsa-miR-644	CLIP-seq
MIRT1544979	hsa-miR-654-5p	CLIP-seq
MIRT2164621	hsa-miR-892a	CLIP-seq
MIRT2383650	hsa-miR-2682	CLIP-seq
MIRT2383651	hsa-miR-3120-3p	CLIP-seq
MIRT2164590	hsa-miR-3158-5p	CLIP-seq
MIRT2164591	hsa-miR-3166	CLIP-seq
MIRT2383652	hsa-miR-34a	CLIP-seq
MIRT2383653	hsa-miR-34c-5p	CLIP-seq
MIRT1544958	hsa-miR-3977	CLIP-seq
MIRT2383654	hsa-miR-4267	CLIP-seq
MIRT2383655	hsa-miR-4436b-3p	CLIP-seq
MIRT2383656	hsa-miR-4476	CLIP-seq
MIRT2383657	hsa-miR-449a	CLIP-seq
MIRT2383658	hsa-miR-449b	CLIP-seq
MIRT2383659	hsa-miR-449c	CLIP-seq
MIRT2383660	hsa-miR-4514	CLIP-seq
MIRT2164611	hsa-miR-4685-5p	CLIP-seq
MIRT2383661	hsa-miR-4692	CLIP-seq
MIRT2164615	hsa-miR-4749-3p	CLIP-seq
MIRT2383662	hsa-miR-4758-3p	CLIP-seq
MIRT2164616	hsa-miR-4771	CLIP-seq
MIRT2383663	hsa-miR-4773	CLIP-seq
MIRT1544977	hsa-miR-499a-5p	CLIP-seq
MIRT1544956	hsa-miR-3692	CLIP-seq
MIRT1544969	hsa-miR-4650-5p	CLIP-seq
MIRT2164611	hsa-miR-4685-5p	CLIP-seq
MIRT2397794	hsa-miR-4733-3p	CLIP-seq
MIRT2696478	hsa-miR-1287	CLIP-seq
MIRT2696479	hsa-miR-193a-5p	CLIP-seq
MIRT2696480	hsa-miR-3135b	CLIP-seq
MIRT2696481	hsa-miR-3978	CLIP-seq
MIRT2164599	hsa-miR-4252	CLIP-seq
MIRT2696482	hsa-miR-431	CLIP-seq
MIRT2696483	hsa-miR-637	CLIP-seq
MIRT2696484	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0008270	Function	Zinc ion binding	IEA

Other IDs

• MIM: 619459
• HGNC: 29027
• e!Ensembl: ENSG00000074755

Protein

• UniProt ID: O43149
• Protein name: Zinc finger ZZ-type and EF-hand domain-containing protein 1
• Protein function: Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03256	ANAPC10	226 → 393	Anaphase-promoting complex, subunit 10 (APC10)	Family
  PF00569	ZZ	1779 → 1820	Zinc finger, ZZ type	Domain
  PF00569	ZZ	1826 → 1870	Zinc finger, ZZ type	Domain

• Sequence:

  MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAA
  AALLPTPPCESLVSRHRGALFRWLEERLGRGEESVTLEQFRELLEARGAGCSSEQFEEAF
  AQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLD
  IHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRS
  PEMDKLKSVAKCYAYIETSSNSADIDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLRH
  LSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQIN
  IKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQT
  VLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFA
  LARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGK
  EDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGL
  VFAYNSSSDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEE
  WDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCR
  KDTEESVCGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQ
  NPREECVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKGVEAAKELYTHLCDVVD
  KVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFTMMNVTEQEHKQSLQLTFRSL
  CTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSVAARECELLMLSGAPGEVGSVL
  FSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVGQFLASMRAILESLFSQYSGKT
  IVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFSVLTELLKKLCSGPEGGLRKLD
  VETWQQEQPVVLHTWTKESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEF
  TDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGLPDVAV
  SWGLDLQLLVSRLMGRLASQCMALKSVRQLGSNMVVPQAKMALVLSSPLWKPVFRHQVCP
  ELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRK
  QAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALSEEFAQVYSLADG
  IRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPESLAKECIEKSLLLLKFLPTGISSKES
  CEKLETADETSHLQPLNKRQRTSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPKLPSS
  SGLPAADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKEKYPVLKDV
  MDFIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQHCAESLGQPHCFHPPFILFLLELL
  TCQKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDRSLLPALSCVQTA
  LLHLLDMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSEWM
  DECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRYRCLQC
  SDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYA
  AKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVD
  GEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSSLEDQALPVT
  VPTGASEEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVSLSKDPSCQTQ
  ISDSPADASPPTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPL
  KSGPTVPLIDLEHVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVL
  SAKHNLFAAGDSSIVPDGWKTTHLLFSLGAVCLDSRVGLDWACSMAEILRSLNSAPLWRD
  VIATFTDHCIKQLPFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFT
  EKNRAVIVDVKTRKRKTVKDYQLVQKGGGQECGDSRAQLSQYSQHFAFIASHLLQSSMDS
  HCPEAVEATWVLSLALKGLYKTLKAHGFEEIRATFLQTDLLKLLVKKCSKGTGFSKTWLL
  RDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEVERPVSSPGDPEQKKLDPLEGLD
  EPTRICFLMAHDALNAPLHILRAIYELQMKKTDYFFLEVQKRFDGDELTTDERIRSLAQR
  WQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISSTESELQQSYA
  KQRRSKSAALLHKELNCKSKRAVRDYLFRVNEATAVLYARHVLASLLAEWPSHVPVSEDI
  LELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLGTMALAACQFMEEPGMEVQ
  VRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSG
  SQQKWKDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVP
  HLPLAKIWEWLVGVACRQTGHQRLKAIHLLLRIVRCCGHSDLCDLALLKPLWQLFTHMEY
  GLFEDVTQPGILLPLHRALTELFFVTENRAQELGVLQDYLLALTTDDHLLRCAAQALQNI
  AAISLAINYPNKATRLWNVEC

• Sequence length: 2961

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28566273, 30054458, 29632382, 30718926