DDN (dendrin)

Gene

• Entrez ID: 23109
• Gene name: Dendrin
• Gene symbol: DDN
• Synonyms: -
• Chromosome: 12
• Chromosome location: 12q13.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018142	hsa-miR-335-5p	Microarray	18185580
MIRT051128	hsa-miR-16-5p	CLASH	23622248
MIRT478339	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT478338	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT478337	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT478336	hsa-miR-4496	PAR-CLIP	23592263
MIRT478334	hsa-miR-1321	PAR-CLIP	23592263
MIRT478335	hsa-miR-4739	PAR-CLIP	23592263
MIRT478333	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT478332	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT478331	hsa-miR-4270	PAR-CLIP	23592263
MIRT478330	hsa-miR-4441	PAR-CLIP	23592263
MIRT478329	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT478328	hsa-miR-1266-5p	PAR-CLIP	23592263
MIRT478327	hsa-miR-4518	PAR-CLIP	23592263
MIRT478326	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT478325	hsa-miR-4738-3p	PAR-CLIP	23592263
MIRT478324	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT478323	hsa-miR-3975	PAR-CLIP	23592263
MIRT478322	hsa-miR-2467-5p	PAR-CLIP	23592263
MIRT478321	hsa-miR-3188	PAR-CLIP	23592263
MIRT478319	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT478320	hsa-miR-4480	PAR-CLIP	23592263
MIRT478318	hsa-miR-3934-3p	PAR-CLIP	23592263
MIRT478317	hsa-miR-3689d	PAR-CLIP	23592263
MIRT478316	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT478315	hsa-miR-3926	PAR-CLIP	23592263
MIRT478314	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT478313	hsa-miR-663b	PAR-CLIP	23592263
MIRT478312	hsa-miR-3616-5p	PAR-CLIP	23592263
MIRT478311	hsa-miR-573	PAR-CLIP	23592263
MIRT478310	hsa-miR-548s	PAR-CLIP	23592263
MIRT478309	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT478339	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT478338	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT478337	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT478336	hsa-miR-4496	PAR-CLIP	23592263
MIRT478334	hsa-miR-1321	PAR-CLIP	23592263
MIRT478335	hsa-miR-4739	PAR-CLIP	23592263
MIRT478333	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT478332	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT478331	hsa-miR-4270	PAR-CLIP	23592263
MIRT478330	hsa-miR-4441	PAR-CLIP	23592263
MIRT478329	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT478328	hsa-miR-1266-5p	PAR-CLIP	23592263
MIRT478327	hsa-miR-4518	PAR-CLIP	23592263
MIRT478326	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT478325	hsa-miR-4738-3p	PAR-CLIP	23592263
MIRT478324	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT478323	hsa-miR-3975	PAR-CLIP	23592263
MIRT478322	hsa-miR-2467-5p	PAR-CLIP	23592263
MIRT478321	hsa-miR-3188	PAR-CLIP	23592263
MIRT478319	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT478320	hsa-miR-4480	PAR-CLIP	23592263
MIRT478318	hsa-miR-3934-3p	PAR-CLIP	23592263
MIRT478317	hsa-miR-3689d	PAR-CLIP	23592263
MIRT478316	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT478315	hsa-miR-3926	PAR-CLIP	23592263
MIRT478314	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT478313	hsa-miR-663b	PAR-CLIP	23592263
MIRT478312	hsa-miR-3616-5p	PAR-CLIP	23592263
MIRT478311	hsa-miR-573	PAR-CLIP	23592263
MIRT478310	hsa-miR-548s	PAR-CLIP	23592263
MIRT478309	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT929379	hsa-miR-1227	CLIP-seq
MIRT929380	hsa-miR-19a	CLIP-seq
MIRT929381	hsa-miR-19b	CLIP-seq
MIRT929382	hsa-miR-2682	CLIP-seq
MIRT929383	hsa-miR-300	CLIP-seq
MIRT929384	hsa-miR-3144-5p	CLIP-seq
MIRT929385	hsa-miR-3154	CLIP-seq
MIRT929386	hsa-miR-3179	CLIP-seq
MIRT929387	hsa-miR-3191	CLIP-seq
MIRT929388	hsa-miR-339-3p	CLIP-seq
MIRT929389	hsa-miR-34a	CLIP-seq
MIRT929390	hsa-miR-34c-5p	CLIP-seq
MIRT929391	hsa-miR-381	CLIP-seq
MIRT929392	hsa-miR-4271	CLIP-seq
MIRT929393	hsa-miR-4302	CLIP-seq
MIRT929394	hsa-miR-4318	CLIP-seq
MIRT929395	hsa-miR-4461	CLIP-seq
MIRT929396	hsa-miR-449a	CLIP-seq
MIRT929397	hsa-miR-449b	CLIP-seq
MIRT929398	hsa-miR-449c	CLIP-seq
MIRT929399	hsa-miR-4514	CLIP-seq
MIRT929400	hsa-miR-4645-5p	CLIP-seq
MIRT929401	hsa-miR-4651	CLIP-seq
MIRT929402	hsa-miR-4652-5p	CLIP-seq
MIRT929403	hsa-miR-4673	CLIP-seq
MIRT929404	hsa-miR-4692	CLIP-seq
MIRT929405	hsa-miR-4693-5p	CLIP-seq
MIRT929406	hsa-miR-4708-3p	CLIP-seq
MIRT929407	hsa-miR-4719	CLIP-seq
MIRT929408	hsa-miR-4725-3p	CLIP-seq
MIRT929409	hsa-miR-4747-5p	CLIP-seq
MIRT929410	hsa-miR-4755-3p	CLIP-seq
MIRT929411	hsa-miR-4760-5p	CLIP-seq
MIRT929412	hsa-miR-524-3p	CLIP-seq
MIRT929413	hsa-miR-525-3p	CLIP-seq
MIRT929414	hsa-miR-608	CLIP-seq
MIRT929415	hsa-miR-648	CLIP-seq
MIRT929416	hsa-miR-765	CLIP-seq
MIRT929417	hsa-miR-892a	CLIP-seq
MIRT1975202	hsa-miR-3664-5p	CLIP-seq
MIRT929401	hsa-miR-4651	CLIP-seq
MIRT929414	hsa-miR-608	CLIP-seq
MIRT2210572	hsa-miR-1254	CLIP-seq
MIRT2210573	hsa-miR-3116	CLIP-seq
MIRT929394	hsa-miR-4318	CLIP-seq
MIRT929405	hsa-miR-4693-5p	CLIP-seq
MIRT929417	hsa-miR-892a	CLIP-seq
MIRT2514522	hsa-miR-23a	CLIP-seq
MIRT2514523	hsa-miR-23b	CLIP-seq
MIRT2514524	hsa-miR-23c	CLIP-seq
MIRT2514525	hsa-miR-3647-5p	CLIP-seq
MIRT2514526	hsa-miR-4717-3p	CLIP-seq
MIRT2514522	hsa-miR-23a	CLIP-seq
MIRT2514523	hsa-miR-23b	CLIP-seq
MIRT2514524	hsa-miR-23c	CLIP-seq
MIRT2514525	hsa-miR-3647-5p	CLIP-seq
MIRT2514526	hsa-miR-4717-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16464232, 16751601
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	16464232
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0032591	Component	Dendritic spine membrane	IEA
GO:0042995	Component	Cell projection	IDA	16464232
GO:0043204	Component	Perikaryon	IEA
GO:0045211	Component	Postsynaptic membrane	IEA

Other IDs

• MIM: 610588
• HGNC: 24458
• e!Ensembl: ENSG00000181418

Protein

• UniProt ID: O94850
• Protein name: Dendrin
• Protein function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15498	Dendrin	55 → 709	Nephrin and CD2AP-binding protein, Dendrin	Family

• Sequence:

  MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAPSRQPMDFQAS
  HWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQER
  EAKETERKRRKAGGARRSPPGRPRPEPRNAPRVAQLAGLPAPLRPERLAPVGRAPRPSAQ
  PQSDPGSAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTL
  GTKRGPGNSQVPTSSAPAATPARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGC
  GAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAKATGSAGTEIAPAGSATAAPCAPHP
  APRSRHHLKGSREGKEGEQIWFPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESLGLGE
  GAGPETLEGWKATRRAHTLPRSSQGLSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPS
  GVTRVVGDSPSQSKPGKEEGEGATVFPSPCQKRLSSSRLLHQPGGGRGGEAEGGRPGDST
  LEERTFRILGLPAPEVNLRDAPTQPGSPEHQALGPAASGAQGRAEGSEVAVVQRRAGRGW
  ARTPGPYAGALREAVSRIRRHTAPDSDTDEAEELSVHSGSSDGSDTEAPGASWRNERTLP
  EVGNSSPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRKRQ

• Sequence length: 711

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		27329760