AKR1B1 (aldo-keto reductase family 1 member B)

Gene

• Entrez ID: 231
• Gene name: Aldo-keto reductase family 1 member B
• Gene symbol: AKR1B1
• Synonyms: ADR, ALDR1, ALR2, AR
• Chromosome: 7
• Chromosome location: 7q33
• Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated i

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025547	hsa-miR-34a-5p	Proteomics	21566225
MIRT038212	hsa-miR-342-5p	CLASH	23622248
MIRT036537	hsa-miR-1226-3p	CLASH	23622248
MIRT776271	hsa-miR-214	CLIP-seq
MIRT776272	hsa-miR-3132	CLIP-seq
MIRT776273	hsa-miR-3154	CLIP-seq
MIRT776274	hsa-miR-330-3p	CLIP-seq
MIRT776275	hsa-miR-3619-5p	CLIP-seq
MIRT776276	hsa-miR-4530	CLIP-seq
MIRT776277	hsa-miR-4650-3p	CLIP-seq
MIRT776278	hsa-miR-761	CLIP-seq
MIRT776271	hsa-miR-214	CLIP-seq
MIRT1929130	hsa-miR-2355-5p	CLIP-seq
MIRT776272	hsa-miR-3132	CLIP-seq
MIRT776275	hsa-miR-3619-5p	CLIP-seq
MIRT1929131	hsa-miR-3679-3p	CLIP-seq
MIRT776276	hsa-miR-4530	CLIP-seq
MIRT776277	hsa-miR-4650-3p	CLIP-seq
MIRT776278	hsa-miR-761	CLIP-seq
MIRT776271	hsa-miR-214	CLIP-seq
MIRT1929130	hsa-miR-2355-5p	CLIP-seq
MIRT776272	hsa-miR-3132	CLIP-seq
MIRT776275	hsa-miR-3619-5p	CLIP-seq
MIRT1929131	hsa-miR-3679-3p	CLIP-seq
MIRT776276	hsa-miR-4530	CLIP-seq
MIRT776277	hsa-miR-4650-3p	CLIP-seq
MIRT776278	hsa-miR-761	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2426162	hsa-miR-3148	CLIP-seq
MIRT2426163	hsa-miR-3662	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2435292	hsa-miR-3660	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2435293	hsa-miR-4526	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2435294	hsa-miR-526b	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2472638	hsa-miR-1264	CLIP-seq
MIRT2472639	hsa-miR-1304	CLIP-seq
MIRT2472640	hsa-miR-139-5p	CLIP-seq
MIRT2472641	hsa-miR-140-3p	CLIP-seq
MIRT2472642	hsa-miR-1827	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2472643	hsa-miR-2110	CLIP-seq
MIRT2472644	hsa-miR-31	CLIP-seq
MIRT2472645	hsa-miR-3144-5p	CLIP-seq
MIRT2426162	hsa-miR-3148	CLIP-seq
MIRT2472646	hsa-miR-3150a-3p	CLIP-seq
MIRT2472647	hsa-miR-3156-3p	CLIP-seq
MIRT2472648	hsa-miR-3191	CLIP-seq
MIRT2472649	hsa-miR-3614-5p	CLIP-seq
MIRT2435292	hsa-miR-3660	CLIP-seq
MIRT2426163	hsa-miR-3662	CLIP-seq
MIRT2472650	hsa-miR-4301	CLIP-seq
MIRT2472651	hsa-miR-4305	CLIP-seq
MIRT2472652	hsa-miR-431	CLIP-seq
MIRT2472653	hsa-miR-4311	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2435293	hsa-miR-4526	CLIP-seq
MIRT2472654	hsa-miR-4652-5p	CLIP-seq
MIRT2472655	hsa-miR-4663	CLIP-seq
MIRT2472656	hsa-miR-4690-5p	CLIP-seq
MIRT2472657	hsa-miR-4701-5p	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2472658	hsa-miR-4719	CLIP-seq
MIRT2472659	hsa-miR-4742-5p	CLIP-seq
MIRT2472660	hsa-miR-4765	CLIP-seq
MIRT2435294	hsa-miR-526b	CLIP-seq
MIRT2472661	hsa-miR-552	CLIP-seq
MIRT2472662	hsa-miR-588	CLIP-seq
MIRT2472663	hsa-miR-626	CLIP-seq
MIRT2472664	hsa-miR-628-5p	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2472665	hsa-miR-720	CLIP-seq
MIRT2472638	hsa-miR-1264	CLIP-seq
MIRT2472639	hsa-miR-1304	CLIP-seq
MIRT2674852	hsa-miR-133a	CLIP-seq
MIRT2674853	hsa-miR-133b	CLIP-seq
MIRT2472640	hsa-miR-139-5p	CLIP-seq
MIRT2472641	hsa-miR-140-3p	CLIP-seq
MIRT2674854	hsa-miR-145	CLIP-seq
MIRT2472642	hsa-miR-1827	CLIP-seq
MIRT2674855	hsa-miR-192	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2472643	hsa-miR-2110	CLIP-seq
MIRT776271	hsa-miR-214	CLIP-seq
MIRT2674856	hsa-miR-215	CLIP-seq
MIRT1929130	hsa-miR-2355-5p	CLIP-seq
MIRT2472644	hsa-miR-31	CLIP-seq
MIRT776272	hsa-miR-3132	CLIP-seq
MIRT2472645	hsa-miR-3144-5p	CLIP-seq
MIRT2426162	hsa-miR-3148	CLIP-seq
MIRT2472646	hsa-miR-3150a-3p	CLIP-seq
MIRT776273	hsa-miR-3154	CLIP-seq
MIRT2472647	hsa-miR-3156-3p	CLIP-seq
MIRT2472648	hsa-miR-3191	CLIP-seq
MIRT776274	hsa-miR-330-3p	CLIP-seq
MIRT2674857	hsa-miR-3529	CLIP-seq
MIRT2674858	hsa-miR-3613-5p	CLIP-seq
MIRT2472649	hsa-miR-3614-5p	CLIP-seq
MIRT776275	hsa-miR-3619-5p	CLIP-seq
MIRT2435292	hsa-miR-3660	CLIP-seq
MIRT2674859	hsa-miR-3661	CLIP-seq
MIRT2426163	hsa-miR-3662	CLIP-seq
MIRT1929131	hsa-miR-3679-3p	CLIP-seq
MIRT2674860	hsa-miR-379	CLIP-seq
MIRT2674861	hsa-miR-3977	CLIP-seq
MIRT2674862	hsa-miR-4274	CLIP-seq
MIRT2472650	hsa-miR-4301	CLIP-seq
MIRT2472651	hsa-miR-4305	CLIP-seq
MIRT2472652	hsa-miR-431	CLIP-seq
MIRT2472653	hsa-miR-4311	CLIP-seq
MIRT2674863	hsa-miR-4451	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2435293	hsa-miR-4526	CLIP-seq
MIRT776276	hsa-miR-4530	CLIP-seq
MIRT776277	hsa-miR-4650-3p	CLIP-seq
MIRT2472654	hsa-miR-4652-5p	CLIP-seq
MIRT2472655	hsa-miR-4663	CLIP-seq
MIRT2472656	hsa-miR-4690-5p	CLIP-seq
MIRT2472657	hsa-miR-4701-5p	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2472658	hsa-miR-4719	CLIP-seq
MIRT2472659	hsa-miR-4742-5p	CLIP-seq
MIRT2674864	hsa-miR-4753-3p	CLIP-seq
MIRT2472660	hsa-miR-4765	CLIP-seq
MIRT2674865	hsa-miR-4766-5p	CLIP-seq
MIRT2674866	hsa-miR-488	CLIP-seq
MIRT2435294	hsa-miR-526b	CLIP-seq
MIRT2472661	hsa-miR-552	CLIP-seq
MIRT2472662	hsa-miR-588	CLIP-seq
MIRT2472663	hsa-miR-626	CLIP-seq
MIRT2472664	hsa-miR-628-5p	CLIP-seq
MIRT2674867	hsa-miR-631	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2472665	hsa-miR-720	CLIP-seq
MIRT776278	hsa-miR-761	CLIP-seq
MIRT2674868	hsa-miR-9	CLIP-seq
MIRT2674869	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
EGR1	Unknown	12890669

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IMP	12732097
GO:0001758	Function	Retinal dehydrogenase activity	IDA	12732097
GO:0001894	Process	Tissue homeostasis	IEA
GO:0002070	Process	Epithelial cell maturation	IEA
GO:0003091	Process	Renal water homeostasis	IEA
GO:0004032	Function	Alditol:NADP+ 1-oxidoreductase activity	EXP	1420136, 15272156
GO:0004032	Function	Alditol:NADP+ 1-oxidoreductase activity	IBA	21873635
GO:0004032	Function	Alditol:NADP+ 1-oxidoreductase activity	IDA	8435445
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005615	Component	Extracellular space	TAS	2112546
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	TAS	2112546
GO:0006061	Process	Sorbitol biosynthetic process	IEA
GO:0006700	Process	C21-steroid hormone biosynthetic process	TAS
GO:0009055	Function	Electron transfer activity	TAS	2112546
GO:0009414	Process	Response to water deprivation	IEA
GO:0018931	Process	Naphthalene metabolic process	IEA
GO:0022900	Process	Electron transport chain	IEA
GO:0031098	Process	Stress-activated protein kinase signaling cascade	IEA
GO:0032838	Component	Plasma membrane bounded cell projection cytoplasm	IEA
GO:0033010	Component	Paranodal junction	IEA
GO:0035809	Process	Regulation of urine volume	IEA
GO:0042415	Process	Norepinephrine metabolic process	IEA
GO:0042572	Process	Retinol metabolic process	IEA
GO:0042629	Component	Mast cell granule	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043220	Component	Schmidt-Lanterman incisure	IEA
GO:0043795	Function	Glyceraldehyde oxidoreductase activity	IDA	20837989
GO:0044597	Process	Daunorubicin metabolic process	IMP	20837989
GO:0044598	Process	Doxorubicin metabolic process	IMP	20837989
GO:0046370	Process	Fructose biosynthetic process	TAS
GO:0046427	Process	Positive regulation of receptor signaling pathway via JAK-STAT	IEA
GO:0047655	Function	Allyl-alcohol dehydrogenase activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IEA
GO:0052650	Function	NADP-retinol dehydrogenase activity	IEA
GO:0060135	Process	Maternal process involved in female pregnancy	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0071475	Process	Cellular hyperosmotic salinity response	IDA	8435445
GO:0072061	Process	Inner medullary collecting duct development	IEA
GO:0072205	Process	Metanephric collecting duct development	IEA
GO:0097066	Process	Response to thyroid hormone	IEA
GO:0097238	Process	Cellular response to methylglyoxal	IEA
GO:0097454	Component	Schwann cell microvillus	IEA
GO:1901653	Process	Cellular response to peptide	IEA

Other IDs

• MIM: 103880
• HGNC: 381
• e!Ensembl: ENSG00000085662

Protein

• UniProt ID: P15121
• Protein name: Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR)
• Protein function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosachari
• PDB: 1ABN, 1ADS, 1AZ1, 1AZ2, 1EF3, 1EL3, 1IEI, 1MAR, 1PWL, 1PWM, 1T40, 1T41, 1US0, 1X96, 1X97, 1X98, 1XGD, 1Z3N, 1Z89, 1Z8A, 2ACQ, 2ACR, 2ACS, 2ACU, 2AGT, 2DUX, 2DUZ, 2DV0, 2F2K, 2FZ8, 2FZ9, 2FZB, 2FZD, 2HV5, 2HVN, 2HVO, 2I16, 2I17, 2IKG, 2IKH, 2IKI, 2IKJ, 2INE, 2INZ, 2IPW, 2IQ0, 2IQD, 2IS7, 2ISF, 2J8T, 2NVC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00248	Aldo_ket_red	15 → 294	Aldo/keto reductase family	Domain

• Sequence:

  MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
  EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
  EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
  AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
  HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
  LLSCTSHKDYPFHEEF

• Sequence length: 316

Pathways

KEGG:

Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Folate biosynthesis
Metabolic pathways

Reactome:

Pregnenolone biosynthesis
Fructose biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cataract	Cataract, Pseudoaphakia	rs118203965, rs118203966, rs104893685, rs121908938, rs104894175, rs121909048, rs28937573, rs121909049, rs121909050, rs74315488, rs80358200, rs80358203, rs121434643, rs56141211, rs132630322, rs121917775, rs121917735, rs121917736, rs137853199, rs137853200, rs121917867, rs121917869, rs121913555, rs104893736, rs121909595, rs121909596, rs121909597, rs28931605, rs121909598, rs104893618, rs1695062782, rs74315486, rs74315487, rs74315490, rs74315489, rs745938679, rs1566402656, rs74315439, rs74315441, rs121912973, rs121917823, rs1593332981, rs121917825, rs121917827, rs113994108, rs387906963, rs387906964, rs1240503246, rs387906965, rs387906966, rs750207077, rs387907336, rs387907337, rs387907342, rs140332366, rs397514703, rs398122937, rs398122378, rs398122392, rs398122944, rs137853924, rs398122947, rs397515623, rs397515624, rs397515625, rs397515626, rs398122948, rs587778872, rs398123066, rs587777601, rs370424081, rs786205221, rs786205222, rs864309684, rs864309688, rs864309701, rs864309689, rs864309690, rs864309681, rs864309686, rs864309696, rs864309693, rs864309687, rs864309691, rs864309692, rs864309695, rs864309678, rs864309685, rs864309700, rs864309698, rs864309683, rs864309682, rs864309679, rs111534978, rs864309680, rs864309702, rs864622780, rs756898971, rs869312732, rs775038545, rs878852983, rs1114167312, rs1114167313, rs1114167314, rs1114167315, rs1114167307, rs886041410, rs886041412, rs1057518738, rs1057517926, rs1057518878, rs1057519616, rs12799308, rs1064793935, rs1064797219, rs1085307126, rs1085307127, rs765628635, rs1114167427, rs1114167433, rs1554744860, rs1554743428, rs747093432, rs1411557416, rs1555179713, rs1481963503, rs1555549755, rs1456161420, rs1555547008, rs1555889308, rs1555888762, rs766522434, rs1264025914, rs1553585262, rs1567671947, rs1337897299, rs764945940, rs1307969607, rs949335475, rs1184095219, rs776129797, rs1569203234, rs1567668570, rs749141857, rs764098604, rs1184398243, rs1578956689, rs1568480054, rs1564745688, rs1564722302, rs1564723150, rs1571175950, rs1569602837, rs1576552712, rs1575369255, rs981126461, rs1570403798, rs200557771, rs1477743112, rs1651879427, rs1651881222, rs1651919374, rs2024441691, rs148284531, rs1246080692	21329682, 25541468, 21376710, 28137510, 28137510, 21329682, 25541468, 21376710
Endometrial carcinoma	Endometrial Carcinoma	rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077, rs587779206, rs63750439, rs63751405, rs63750741, rs63750854, rs63750909, rs587779212, rs63749874, rs267608076, rs587779220, rs63750735, rs267608082, rs587779227, rs267608068, rs63750075, rs587779232, rs267608058, rs63751127, rs63750138, rs267608065, rs63751017, rs587779246, rs63750111, rs63750563, rs267608073, rs63751407, rs63749999, rs267608042, rs63750833, rs587779255, rs587779256, rs267608078, rs267608092, rs587779263, rs267608098, rs587779267, rs63750194, rs63751327, rs63751328, rs587779284, rs63749942, rs63751058, rs267608114, rs267608118, rs63751319, rs267608128, rs1553333594, rs267608126, rs63750767, rs267608120, rs267608121, rs267608122, rs63750342, rs63749873, rs587779318, rs63750019, rs63749980, rs267608048, rs1553412283, rs146816935, rs63750855, rs63751711, rs267607789, rs587779094, rs63750224, rs267607972, rs63750084, rs587779185, rs587778617, rs398123231, rs398123232, rs398123318, rs587780021, rs63750119, rs267608064, rs587781490, rs587781558, rs587781691, rs63749821, rs587782111, rs587782326, rs587782704, rs587779264, rs587779333, rs587782712, rs587783056, rs730881825, rs730881827, rs730881829, rs730881830, rs786202193, rs587782281, rs786202848, rs786201049, rs750528093, rs786202108, rs267608083, rs786201050, rs786203924, rs587781544, rs786201084, rs1553333738, rs863224829, rs863225398, rs863225409, rs863225412, rs864622041, rs869312769, rs869312770, rs63751077, rs876661205, rs876661025, rs63749919, rs876661073, rs876661222, rs267608041, rs878853702, rs751326348, rs866260675, rs886039666, rs886044911, rs1057517552, rs1057517764, rs1057517763, rs121909224, rs1057520605, rs1060502885, rs1060502918, rs1060502932, rs587779215, rs1060502937, rs1060502886, rs1060502875, rs1060502881, rs267607939, rs1023534466, rs1064793600, rs1064795256, rs1064795591, rs1064794055, rs1064794164, rs1553414010, rs1064793671, rs1064794302, rs1064793489, rs1064794384, rs1064793781, rs1553333500, rs760190301, rs1114167719, rs1114167776, rs1114167704, rs1114167748, rs1114167731, rs753796271, rs267608055, rs1114167746, rs1114167715, rs587782706, rs1114167750, rs1114167765, rs1114167747, rs786204048, rs1114167707, rs1114167767, rs1114167717, rs1114167783, rs1553412966, rs1553333598, rs587779297, rs1554294505, rs988423880, rs1554306353, rs1553408136, rs1553333321, rs1553408388, rs63749973, rs1553412064, rs1553412120, rs1553826166, rs1553413784, rs1553331242, rs1553414519, rs1564568660, rs1558392033, rs878853704, rs765763906, rs1558663559, rs1572720704, rs63750985, rs1572727440, rs587779253, rs1580538168, rs149350323, rs374133543, rs771721952, rs201033017, rs763478027, rs1475633334, rs1580553624, rs1580553669, rs578113271, rs757194485, rs539295465, rs778610412, rs758191157, rs1580597397, rs1580033751, rs751236312, rs376667075, rs1561486630, rs1561486632, rs777054839, rs1204002507, rs766672143, rs1580091499, rs1386063673, rs1450314617, rs1580027713, rs367544716, rs1488467945, rs1580053768, rs1580553607, rs1572720794, rs1572722039, rs1572723786, rs1572725235, rs1572728112, rs1175196087, rs1572741984, rs1580540688, rs1259647122, rs1580546793, rs1234762807, rs1580556516, rs1669245178, rs1669365820, rs756190979, rs371356175, rs766997264, rs1743353294, rs1379605717, rs770330684, rs1462955256, rs1744356274, rs1480047980, rs1744149615	23146748

Unknown
Disease name	Disease term	dbSNP ID	References
Endometrial neoplasms	Endometrial Neoplasms		23146748
Endometrioma	Endometrioma		25446850
Endometriosis	Endometriosis	rs1800629, rs1143634	25446850
Respiratory distress syndrome	Respiratory Distress Syndrome, Adult		25070658