RRP1B (ribosomal RNA processing 1B)

Gene

• Entrez ID: 23076
• Gene name: Ribosomal RNA processing 1B
• Gene symbol: RRP1B
• Synonyms: KIAA0179, NNP1L, Nnp1, PPP1R136, RRP1
• Chromosome: 21
• Chromosome location: 21q22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005231	hsa-let-7b-5p	pSILAC, Proteomics	18668040
MIRT025330	hsa-miR-34a-5p	Proteomics	21566225
MIRT027588	hsa-miR-98-5p	Microarray	19088304
MIRT036131	hsa-miR-1296-5p	CLASH	23622248
MIRT036605	hsa-miR-940	CLASH	23622248
MIRT037837	hsa-miR-455-3p	CLASH	23622248
MIRT040297	hsa-miR-615-3p	CLASH	23622248
MIRT041010	hsa-miR-505-3p	CLASH	23622248
MIRT042232	hsa-miR-484	CLASH	23622248
MIRT042696	hsa-miR-196b-5p	CLASH	23622248
MIRT043565	hsa-miR-331-3p	CLASH	23622248
MIRT045276	hsa-miR-186-5p	CLASH	23622248
MIRT045704	hsa-miR-125a-5p	CLASH	23622248
MIRT047655	hsa-miR-10a-5p	CLASH	23622248
MIRT298673	hsa-miR-548m	PAR-CLIP	20371350
MIRT565942	hsa-miR-302a-5p	PAR-CLIP	20371350
MIRT611031	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT611031	hsa-miR-6749-3p	HITS-CLIP	28735896
MIRT611032	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT611032	hsa-miR-6792-3p	HITS-CLIP	28735896
MIRT611033	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT611033	hsa-miR-4691-5p	HITS-CLIP	28735896
MIRT611034	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT611034	hsa-miR-452-3p	HITS-CLIP	28735896
MIRT611035	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT611035	hsa-miR-150-5p	HITS-CLIP	28735896
MIRT611036	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT611036	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT626165	hsa-miR-891b	HITS-CLIP	23824327
MIRT626166	hsa-miR-4772-3p	HITS-CLIP	23824327

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Unknown	20040599

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001652	Component	Granular component	IDA	20926688
GO:0003713	Function	Transcription coactivator activity	IMP	20040599
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	19389623, 19710015, 20040599, 20926688, 23604122, 24366813, 26311876, 27173435, 28330616, 29568061
GO:0005634	Component	Nucleus	HDA	16780588
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IDA	20040599, 26311876
GO:0005829	Component	Cytosol	HDA	16780588
GO:0006364	Process	RRNA processing	IBA	21873635
GO:0006397	Process	MRNA processing	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0010923	Process	Negative regulation of phosphatase activity	IDA	19389623
GO:0016032	Process	Viral process	IEA
GO:0030687	Component	Preribosome, large subunit precursor	IBA	21873635
GO:0030688	Component	Preribosome, small subunit precursor	IEA
GO:0034260	Process	Negative regulation of GTPase activity	ISS
GO:0043065	Process	Positive regulation of apoptotic process	IMP	20040599
GO:0043484	Process	Regulation of RNA splicing	ISS
GO:0043923	Process	Positive regulation by host of viral transcription	IMP	26311876
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	20040599
GO:0098586	Process	Cellular response to virus	IDA	26311876

Other IDs

• MIM: 610654
• HGNC: 23818
• e!Ensembl: ENSG00000160208

Protein

• UniProt ID: Q14684
• Protein name: Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)
• Protein function: Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015). ; (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05997	Nop52	10 → 218	Nucleolar protein,Nop52	Family

• Sequence:

  MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELLKIWKGLFY
  CMWVQDEPLLQEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYML
  IRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKVG
  GKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFEAIVDQSPFVPEETMEEQKTKVG
  DGDLSAEEIPENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDY
  KAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQILSQ
  GKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPGGAA
  PSLEQNRGREPEASGLKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRKRPRKKSP
  RAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTP
  AWPPLQQEGPPTGPAEGANSHTTLPQRRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMR
  VMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQKLRAESDFVKFDTPFLPKPLFFRRAK
  SSTATHPPGPAVQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGPSRVAFDPEQK
  PLHGVLKTPTSSPASSPLVAKKPLTTTPRRRPRAMDFF

• Sequence length: 758

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778