Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
23071 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Endoplasmic reticulum protein 44 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
ERP44 |
SynonymsGene synonyms aliases
|
PDIA10, TXNDC4 |
ChromosomeChromosome number
|
9 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
9q31.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-rete |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
|
Transcription factor |
Regulation |
Reference |
PPARG |
Activation |
20484463 |
PPARG |
Repression |
20484463 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q9BS26 |
Protein name |
Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) |
Protein function |
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652 |
PDB |
2R2J
,
5GU6
,
5GU7
,
5HQP
,
5XWM
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00085 |
Thioredoxin |
30 → 138 |
Thioredoxin |
Domain |
PF13848 |
Thioredoxin_6 |
167 → 350 |
|
Domain |
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Sequence |
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Sequence length |
406 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17013881 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Prostatic neoplasms |
Prostatic Neoplasms |
|
17013881 |
|