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ERP44 (endoplasmic reticulum protein 44)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23071
Gene nameGene Name - the full gene name approved by the HGNC.
Endoplasmic reticulum protein 44
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ERP44
SynonymsGene synonyms aliases
PDIA10, TXNDC4
ChromosomeChromosome number
9
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q31.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-rete
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019815 hsa-miR-375 Microarray 20215506
MIRT049949 hsa-miR-30a-5p CLASH 23622248
MIRT719615 hsa-miR-548p HITS-CLIP 19536157
MIRT719614 hsa-miR-519d-5p HITS-CLIP 19536157
MIRT719613 hsa-miR-5695 HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
PPARG Activation 20484463
PPARG Repression 20484463
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003756 Function Protein disulfide isomerase activity IDA 11847130
GO:0005515 Function Protein binding IPI 17805346, 32814053
GO:0005576 Component Extracellular region TAS
GO:0005788 Component Endoplasmic reticulum lumen IDA 11847130
GO:0005789 Component Endoplasmic reticulum membrane IDA 11847130
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9BS26
Protein name Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4)
Protein function Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652
PDB 2R2J , 5GU6 , 5GU7 , 5HQP , 5XWM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00085 Thioredoxin
30 138
Thioredoxin
Domain
PF13848 Thioredoxin_6
167 350
Domain
Sequence
Sequence length 406
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Neutrophil degranulation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 17013881

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