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SAMD4A (sterile alpha motif domain containing 4A)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23034
Gene nameGene Name - the full gene name approved by the HGNC.
Sterile alpha motif domain containing 4A
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SAMD4A
SynonymsGene synonyms aliases
SAMD4, SMAUG, SMAUG1, SMG, SMGA
ChromosomeChromosome number
14
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q22.2
SummarySummary of gene provided in NCBI Entrez Gene.
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Sma
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019866 hsa-miR-375 Microarray 20215506
MIRT720127 hsa-miR-6895-5p HITS-CLIP 19536157
MIRT720126 hsa-miR-3158-3p HITS-CLIP 19536157
MIRT720125 hsa-miR-3918 HITS-CLIP 19536157
MIRT720124 hsa-miR-4685-5p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
SRF Activation 16814806
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening IBA 21873635
GO:0000932 Component P-body IBA 21873635
GO:0001650 Component Fibrillar center IDA
GO:0003723 Function RNA binding HDA 22658674
GO:0003729 Function MRNA binding IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9UPU9
Protein name Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A)
Protein function Acts as a translational repressor of SRE-containing messengers.
PDB 8OIK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00536 SAM_1
321 381
SAM domain (Sterile alpha motif)
Domain
Sequence
MMFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSQTQARFLQLCLEHSLADCAELHVLER
EANSPGIINQWQQESKDKVISLLLTHLPLLKPGNLDAKVEYMKLLPKILAHSIEHNQHIE
ESRQLLSYALIHPATSLEDRSALAMWLNHLEDRTSTSFGGQNRGRSDSVDYGQTHYYHQR
QNSDDKLNGWQNSRDSGICINASNWQDKSMGCENGHVPLYSSSSVPTTINTIGTSTSTIL
SGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASS
GSGGSEHLEDQTTARNTFQEEGSGMKDVPAWLKSLRLHKYAALFSQMTYEEMMALTECQL
EAQNVTKGARHKIVISIQKLK
ERQNLLKSLERDIIEGGSLRIPLQELHQMILTPIKAYSS
PSTTPEARRREPQAPRQPSLMGPESQSPDCKDGAAATGATATPSAGASGGLQPHQLSSCD
GELAVAPLPEGDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKCLIHEAFTETQKK
RLLSWKQQVQKLFRSFPRKTLLDISGYRQQRNRGFGQSNSLPTAGSVGGGMGRRNPRQYQ
IPSRNVPSARLGLLGTSGFVSSNQRNTTATPTIMKQGRQNLWFANPGGSNSMPSRTHSSV
QRTRSLPVHTSPQNMLMFQQPEFQLPVTEPDINNRLESLCLSMTEHALGDGVDRTSTI
Sequence length 718
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lip and oral cavity carcinoma Lip and Oral Cavity Carcinoma rs121913388, rs121912651, rs11540652, rs28934573, rs28934578, rs28933406, rs104894229, rs104894230, rs121913273, rs104894228, rs587778720, rs55832599, rs121913344, rs587782705, rs104894226, rs730882001, rs876660754, rs876660726, rs2124437, rs1335022, rs4512367, rs121913449, rs121913454, rs121913389, rs1057519927, rs243865, rs10090787, rs9849237, rs1957358, rs2306058, rs11130760, rs985033810, rs868137297
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 27846195
Unknown
Disease name Disease term dbSNP ID References
Atherosclerosis Atherosclerosis rs699947, rs59439148 23152477

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