SPEN (spen family transcriptional repressor)

Gene

• Entrez ID: 23013
• Gene name: Spen family transcriptional repressor
• Gene symbol: SPEN
• Synonyms: HIAA0929, MINT, RATARS, RBM15C, SHARP
• Chromosome: 1
• Chromosome location: 1p36.21-p36.13
• Summary: This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestrat

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019521	hsa-miR-151a-5p	Sequencing	20371350
MIRT051293	hsa-miR-16-5p	CLASH	23622248
MIRT049048	hsa-miR-92a-3p	CLASH	23622248
MIRT048159	hsa-miR-196a-5p	CLASH	23622248
MIRT046031	hsa-miR-125b-5p	CLASH	23622248
MIRT045089	hsa-miR-186-5p	CLASH	23622248
MIRT044789	hsa-miR-320a	CLASH	23622248
MIRT044364	hsa-miR-106b-5p	CLASH	23622248
MIRT043756	hsa-miR-328-3p	CLASH	23622248
MIRT043465	hsa-miR-331-3p	CLASH	23622248
MIRT043099	hsa-miR-324-5p	CLASH	23622248
MIRT042502	hsa-miR-423-3p	CLASH	23622248
MIRT041415	hsa-miR-193b-3p	CLASH	23622248
MIRT041415	hsa-miR-193b-3p	CLASH	23622248
MIRT039949	hsa-miR-615-3p	CLASH	23622248
MIRT039166	hsa-miR-769-5p	CLASH	23622248
MIRT038656	hsa-miR-23b-5p	CLASH	23622248
MIRT037187	hsa-miR-877-3p	CLASH	23622248
MIRT755932	hsa-miR-6779-5p	Luciferase reporter assay, Western blotting, qRT-PCR, in vitro cullelar assays, Flow cytometry	36087384
MIRT1383699	hsa-miR-1238	CLIP-seq
MIRT1383700	hsa-miR-1271	CLIP-seq
MIRT1383701	hsa-miR-1273f	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT1383703	hsa-miR-182	CLIP-seq
MIRT1383704	hsa-miR-18a	CLIP-seq
MIRT1383705	hsa-miR-18b	CLIP-seq
MIRT1383706	hsa-miR-214	CLIP-seq
MIRT1383707	hsa-miR-300	CLIP-seq
MIRT1383708	hsa-miR-30a	CLIP-seq
MIRT1383709	hsa-miR-30b	CLIP-seq
MIRT1383710	hsa-miR-30c	CLIP-seq
MIRT1383711	hsa-miR-30d	CLIP-seq
MIRT1383712	hsa-miR-30e	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT1383714	hsa-miR-3120-3p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT1383716	hsa-miR-3128	CLIP-seq
MIRT1383717	hsa-miR-329	CLIP-seq
MIRT1383718	hsa-miR-337-5p	CLIP-seq
MIRT1383719	hsa-miR-34a	CLIP-seq
MIRT1383720	hsa-miR-34c-5p	CLIP-seq
MIRT1383721	hsa-miR-3607-3p	CLIP-seq
MIRT1383722	hsa-miR-3617	CLIP-seq
MIRT1383723	hsa-miR-3618	CLIP-seq
MIRT1383724	hsa-miR-362-3p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT1383726	hsa-miR-381	CLIP-seq
MIRT1383727	hsa-miR-3941	CLIP-seq
MIRT1383728	hsa-miR-4436a	CLIP-seq
MIRT1383729	hsa-miR-4481	CLIP-seq
MIRT1383730	hsa-miR-449a	CLIP-seq
MIRT1383731	hsa-miR-449b	CLIP-seq
MIRT1383732	hsa-miR-4504	CLIP-seq
MIRT1383733	hsa-miR-4537	CLIP-seq
MIRT1383734	hsa-miR-4666-3p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT1383736	hsa-miR-4720-5p	CLIP-seq
MIRT1383737	hsa-miR-4745-5p	CLIP-seq
MIRT1383738	hsa-miR-4758-5p	CLIP-seq
MIRT1383739	hsa-miR-4766-5p	CLIP-seq
MIRT1383740	hsa-miR-4778-3p	CLIP-seq
MIRT1383741	hsa-miR-4783-3p	CLIP-seq
MIRT1383742	hsa-miR-4789-5p	CLIP-seq
MIRT1383743	hsa-miR-4799-3p	CLIP-seq
MIRT1383744	hsa-miR-520a-5p	CLIP-seq
MIRT1383745	hsa-miR-525-5p	CLIP-seq
MIRT1383746	hsa-miR-542-3p	CLIP-seq
MIRT1383747	hsa-miR-545	CLIP-seq
MIRT1383748	hsa-miR-548g	CLIP-seq
MIRT1383749	hsa-miR-570	CLIP-seq
MIRT1383750	hsa-miR-603	CLIP-seq
MIRT1383751	hsa-miR-641	CLIP-seq
MIRT1383752	hsa-miR-96	CLIP-seq
MIRT2114838	hsa-miR-1233	CLIP-seq
MIRT1383700	hsa-miR-1271	CLIP-seq
MIRT2114839	hsa-miR-1285	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT2114840	hsa-miR-1323	CLIP-seq
MIRT1383703	hsa-miR-182	CLIP-seq
MIRT1383706	hsa-miR-214	CLIP-seq
MIRT2114841	hsa-miR-217	CLIP-seq
MIRT2114842	hsa-miR-224	CLIP-seq
MIRT2114843	hsa-miR-2355-3p	CLIP-seq
MIRT2114844	hsa-miR-2467-3p	CLIP-seq
MIRT1383708	hsa-miR-30a	CLIP-seq
MIRT1383709	hsa-miR-30b	CLIP-seq
MIRT1383710	hsa-miR-30c	CLIP-seq
MIRT1383711	hsa-miR-30d	CLIP-seq
MIRT1383712	hsa-miR-30e	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT2114845	hsa-miR-3121-5p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT2114846	hsa-miR-3158-5p	CLIP-seq
MIRT2114847	hsa-miR-3187-5p	CLIP-seq
MIRT2114848	hsa-miR-323b-5p	CLIP-seq
MIRT1383721	hsa-miR-3607-3p	CLIP-seq
MIRT2114849	hsa-miR-3678-3p	CLIP-seq
MIRT2114850	hsa-miR-3691-3p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT2114851	hsa-miR-3940-5p	CLIP-seq
MIRT2114852	hsa-miR-412	CLIP-seq
MIRT2114853	hsa-miR-4292	CLIP-seq
MIRT2114854	hsa-miR-4418	CLIP-seq
MIRT2114855	hsa-miR-4420	CLIP-seq
MIRT2114856	hsa-miR-4421	CLIP-seq
MIRT2114857	hsa-miR-4450	CLIP-seq
MIRT2114858	hsa-miR-4507	CLIP-seq
MIRT2114859	hsa-miR-4525	CLIP-seq
MIRT2114860	hsa-miR-4646-5p	CLIP-seq
MIRT2114861	hsa-miR-4699-5p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT2114862	hsa-miR-4735-5p	CLIP-seq
MIRT2114863	hsa-miR-4747-5p	CLIP-seq
MIRT2114864	hsa-miR-4787-5p	CLIP-seq
MIRT2114865	hsa-miR-509-3-5p	CLIP-seq
MIRT2114866	hsa-miR-509-5p	CLIP-seq
MIRT1383744	hsa-miR-520a-5p	CLIP-seq
MIRT1383745	hsa-miR-525-5p	CLIP-seq
MIRT2114867	hsa-miR-548a-3p	CLIP-seq
MIRT2114868	hsa-miR-548e	CLIP-seq
MIRT2114869	hsa-miR-548f	CLIP-seq
MIRT1383748	hsa-miR-548g	CLIP-seq
MIRT2114870	hsa-miR-548o	CLIP-seq
MIRT2114871	hsa-miR-612	CLIP-seq
MIRT2114872	hsa-miR-676	CLIP-seq
MIRT2114873	hsa-miR-759	CLIP-seq
MIRT1383752	hsa-miR-96	CLIP-seq
MIRT1383700	hsa-miR-1271	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT1383703	hsa-miR-182	CLIP-seq
MIRT1383706	hsa-miR-214	CLIP-seq
MIRT2114842	hsa-miR-224	CLIP-seq
MIRT1383708	hsa-miR-30a	CLIP-seq
MIRT1383709	hsa-miR-30b	CLIP-seq
MIRT1383710	hsa-miR-30c	CLIP-seq
MIRT1383711	hsa-miR-30d	CLIP-seq
MIRT1383712	hsa-miR-30e	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT1383714	hsa-miR-3120-3p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT1383717	hsa-miR-329	CLIP-seq
MIRT1383718	hsa-miR-337-5p	CLIP-seq
MIRT1383721	hsa-miR-3607-3p	CLIP-seq
MIRT1383722	hsa-miR-3617	CLIP-seq
MIRT1383723	hsa-miR-3618	CLIP-seq
MIRT1383724	hsa-miR-362-3p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT1383727	hsa-miR-3941	CLIP-seq
MIRT1383728	hsa-miR-4436a	CLIP-seq
MIRT2114857	hsa-miR-4450	CLIP-seq
MIRT2114859	hsa-miR-4525	CLIP-seq
MIRT1383733	hsa-miR-4537	CLIP-seq
MIRT2337581	hsa-miR-4652-3p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT1383739	hsa-miR-4766-5p	CLIP-seq
MIRT1383741	hsa-miR-4783-3p	CLIP-seq
MIRT1383742	hsa-miR-4789-5p	CLIP-seq
MIRT1383747	hsa-miR-545	CLIP-seq
MIRT1383748	hsa-miR-548g	CLIP-seq
MIRT1383749	hsa-miR-570	CLIP-seq
MIRT1383750	hsa-miR-603	CLIP-seq
MIRT1383751	hsa-miR-641	CLIP-seq
MIRT2337582	hsa-miR-934	CLIP-seq
MIRT1383752	hsa-miR-96	CLIP-seq
MIRT1383707	hsa-miR-300	CLIP-seq
MIRT1383708	hsa-miR-30a	CLIP-seq
MIRT1383709	hsa-miR-30b	CLIP-seq
MIRT1383710	hsa-miR-30c	CLIP-seq
MIRT1383711	hsa-miR-30d	CLIP-seq
MIRT1383712	hsa-miR-30e	CLIP-seq
MIRT2460399	hsa-miR-380	CLIP-seq
MIRT1383726	hsa-miR-381	CLIP-seq
MIRT2460400	hsa-miR-3924	CLIP-seq
MIRT2460401	hsa-miR-4422	CLIP-seq
MIRT2460402	hsa-miR-4495	CLIP-seq
MIRT2460403	hsa-miR-624	CLIP-seq
MIRT1383699	hsa-miR-1238	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT2631111	hsa-miR-1289	CLIP-seq
MIRT1383707	hsa-miR-300	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT1383714	hsa-miR-3120-3p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT1383716	hsa-miR-3128	CLIP-seq
MIRT2631112	hsa-miR-3198	CLIP-seq
MIRT1383718	hsa-miR-337-5p	CLIP-seq
MIRT1383719	hsa-miR-34a	CLIP-seq
MIRT1383720	hsa-miR-34c-5p	CLIP-seq
MIRT2631113	hsa-miR-3647-3p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT1383726	hsa-miR-381	CLIP-seq
MIRT2631114	hsa-miR-4294	CLIP-seq
MIRT2631115	hsa-miR-4309	CLIP-seq
MIRT2631116	hsa-miR-4427	CLIP-seq
MIRT1383728	hsa-miR-4436a	CLIP-seq
MIRT1383729	hsa-miR-4481	CLIP-seq
MIRT1383730	hsa-miR-449a	CLIP-seq
MIRT1383731	hsa-miR-449b	CLIP-seq
MIRT2631117	hsa-miR-4517	CLIP-seq
MIRT1383733	hsa-miR-4537	CLIP-seq
MIRT1383734	hsa-miR-4666-3p	CLIP-seq
MIRT2631118	hsa-miR-4680-3p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT1383736	hsa-miR-4720-5p	CLIP-seq
MIRT1383737	hsa-miR-4745-5p	CLIP-seq
MIRT1383738	hsa-miR-4758-5p	CLIP-seq
MIRT1383742	hsa-miR-4789-5p	CLIP-seq
MIRT1383743	hsa-miR-4799-3p	CLIP-seq
MIRT2631119	hsa-miR-520d-5p	CLIP-seq
MIRT2631120	hsa-miR-524-5p	CLIP-seq
MIRT1383747	hsa-miR-545	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT2631111	hsa-miR-1289	CLIP-seq
MIRT1383707	hsa-miR-300	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT1383716	hsa-miR-3128	CLIP-seq
MIRT2631112	hsa-miR-3198	CLIP-seq
MIRT1383719	hsa-miR-34a	CLIP-seq
MIRT1383720	hsa-miR-34c-5p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT1383726	hsa-miR-381	CLIP-seq
MIRT2631114	hsa-miR-4294	CLIP-seq
MIRT2631115	hsa-miR-4309	CLIP-seq
MIRT1383729	hsa-miR-4481	CLIP-seq
MIRT1383730	hsa-miR-449a	CLIP-seq
MIRT1383731	hsa-miR-449b	CLIP-seq
MIRT1383734	hsa-miR-4666-3p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT1383736	hsa-miR-4720-5p	CLIP-seq
MIRT1383737	hsa-miR-4745-5p	CLIP-seq
MIRT1383738	hsa-miR-4758-5p	CLIP-seq
MIRT1383742	hsa-miR-4789-5p	CLIP-seq
MIRT1383743	hsa-miR-4799-3p	CLIP-seq
MIRT2691865	hsa-miR-495	CLIP-seq
MIRT2691866	hsa-miR-548ac	CLIP-seq
MIRT2691867	hsa-miR-548ae	CLIP-seq
MIRT2691868	hsa-miR-548aj	CLIP-seq
MIRT2691869	hsa-miR-548am	CLIP-seq
MIRT2691870	hsa-miR-548d-3p	CLIP-seq
MIRT2691871	hsa-miR-548x	CLIP-seq
MIRT2691872	hsa-miR-548z	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	16287852
GO:0000398	Process	MRNA splicing, via spliceosome	IBA	21873635
GO:0001085	Function	RNA polymerase II transcription factor binding	IPI	16287852
GO:0003676	Function	Nucleic acid binding	IBA	21873635
GO:0003677	Function	DNA binding	IEA
GO:0003714	Function	Transcription corepressor activity	IDA	16287852
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	16129689, 16287852, 17474147, 21102556, 24268649, 25609649
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0016032	Process	Viral process	IEA
GO:0017053	Component	Transcription repressor complex	IDA	16287852
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	16129689
GO:0050769	Process	Positive regulation of neurogenesis	IMP	16287852
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 613484
• HGNC: 17575
• e!Ensembl: ENSG00000065526

Protein

• UniProt ID: Q96T58
• Protein name: Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)
• Protein function: May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive eleme
• PDB: 1OW1, 2RT5, 4P6Q, 7Z1K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	8 → 75	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	337 → 407	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	440 → 507	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	519 → 583	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF07744	SPOC	3499 → 3664	SPOC domain	Domain

• Sequence:

  MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQ
  KAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPP
  SLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQH
  GLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHS
  RSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSS
  SSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFK
  KFGKVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWIGPETESEN
  EFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAF
  LQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRY
  GPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCME
  KSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSE
  WETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERR
  PIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKS
  RLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQ
  ENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLK
  AKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKA
  RKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQP
  DVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRP
  SSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDET
  PERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVD
  EYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGG
  SPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQM
  ADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPS
  DSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTI
  TPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKI
  RTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRI
  YGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTP
  ESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVS
  EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGA
  SFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPP
  ASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG
  EAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPV
  KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG
  WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSE
  QKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAV
  SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSP
  EATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIG
  SIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATE
  SSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRR
  KRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTS
  DLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVT
  PPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPP
  DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK
  PLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLA
  KPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVL
  TGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTV
  TMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYS
  GQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANV
  ATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPP
  VLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNH
  VPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAA
  GIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSP
  RAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVM
  QSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAK
  AAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSG
  ELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQST
  QPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQ
  RAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQP
  APKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPL
  SEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFI
  TYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIV
  IASV

• Sequence length: 3664

Pathways

KEGG:

Notch signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Diffuse lymphoma	Diffuse Large B-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291
Non-hodgkin lymphoma	Lymphoma, Non-Hodgkin	rs121908689, rs28936699, rs121909775, rs398122800, rs121913357, rs121913355, rs398122820
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		29610475
Salivary gland neoplasm	Salivary Gland Neoplasms