MYH15 (myosin heavy chain 15)

Gene

• Entrez ID: 22989
• Gene name: Myosin heavy chain 15
• Gene symbol: MYH15
• Synonyms: -
• Chromosome: 3
• Chromosome location: 3q13.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT711480	hsa-miR-7161-3p	HITS-CLIP	19536157
MIRT711479	hsa-miR-6888-5p	HITS-CLIP	19536157
MIRT711478	hsa-miR-617	HITS-CLIP	19536157
MIRT711477	hsa-miR-6505-3p	HITS-CLIP	19536157
MIRT711476	hsa-miR-4683	HITS-CLIP	19536157
MIRT711480	hsa-miR-7161-3p	HITS-CLIP	19536157
MIRT711479	hsa-miR-6888-5p	HITS-CLIP	19536157
MIRT711478	hsa-miR-617	HITS-CLIP	19536157
MIRT711477	hsa-miR-6505-3p	HITS-CLIP	19536157
MIRT711476	hsa-miR-4683	HITS-CLIP	19536157
MIRT1168321	hsa-miR-3152-5p	CLIP-seq
MIRT1168322	hsa-miR-3671	CLIP-seq
MIRT1168323	hsa-miR-4666-5p	CLIP-seq
MIRT1168324	hsa-miR-4774-3p	CLIP-seq
MIRT1168325	hsa-miR-607	CLIP-seq
MIRT2048511	hsa-miR-4663	CLIP-seq
MIRT2048512	hsa-miR-4689	CLIP-seq
MIRT2048513	hsa-miR-579	CLIP-seq
MIRT2048514	hsa-miR-664	CLIP-seq
MIRT2277374	hsa-miR-3179	CLIP-seq
MIRT2048511	hsa-miR-4663	CLIP-seq
MIRT2048513	hsa-miR-579	CLIP-seq
MIRT2391249	hsa-miR-1236	CLIP-seq
MIRT2391250	hsa-miR-3663-5p	CLIP-seq
MIRT2391251	hsa-miR-593	CLIP-seq
MIRT2391252	hsa-miR-626	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002074	Process	Extraocular skeletal muscle development	IEA
GO:0003774	Function	Motor activity	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	IDA
GO:0016459	Component	Myosin complex	IEA
GO:0030016	Component	Myofibril	IEA
GO:0032982	Component	Myosin filament	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0051015	Function	Actin filament binding	IEA

Other IDs

• MIM: 609929
• HGNC: 31073
• e!Ensembl: ENSG00000144821

Protein

• UniProt ID: Q9Y2K3
• Protein name: Myosin-15 (Myosin heavy chain 15)
• Protein function: Muscle contraction.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02736	Myosin_N	51 → 91	Myosin N-terminal SH3-like domain	Domain
  PF00063	Myosin_head	105 → 778	Myosin head (motor domain)	Domain
  PF01576	Myosin_tail_1	856 → 1936	Myosin tail	Coiled-coil

• Sequence:

  MVESCLLTFRAFFWWIALIKMDLSDLGEAAAFLRRSEAELLLLQATALDGKKKCWIPDGE
  NAYIEAEVKGSEDDGTVIVETADGESLSIKEDKIQQMNPPEFEMIEDMAMLTHLNEASVL
  HTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAF
  QDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAAMIESRKKQGALEDQIMQANTIL
  EAFGNAKTLRNDNSSRFGKFIRMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFY
  QILSGQKELHDLLLVSANPSDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPDEKYG
  CYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKCLIHPRIKVGN
  EYVTRGQTIEQVTCAVGALSKSMYERMFKWLVARINRALDAKLSRQFFIGILDITGFEIL
  EYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIEKPM
  GILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQKPKPDKKKFEAHFELVHYAGVVPY
  NISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYMSTDSAIPFGEKKRKKGASFQTVA
  SLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILDPYLVLQQLRCNGVLEGTRICREG
  FPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEELLGSLEIDHTQYRFGITKVFFKAG
  FLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWP
  WMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLI
  LQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECF
  ELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLD
  DLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMEN
  LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTT
  RAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETT
  SASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKL
  CTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNF
  TRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEM
  VQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDA
  LSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTY
  EESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETE
  GALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSR
  IEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLK
  EQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKK
  KLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQ
  TITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIK
  ELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKE
  RAEVAESQVNKLKIKAREFGKKVQEE

• Sequence length: 1946

Pathways

KEGG:

Motor proteins
Cytoskeleton in muscle cells

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	30595370