SORCS3 (sortilin related VPS10 domain containing receptor 3)

Gene

• Entrez ID: 22986
• Gene name: Sortilin related VPS10 domain containing receptor 3
• Gene symbol: SORCS3
• Synonyms: SORCS
• Chromosome: 10
• Chromosome location: 10q25.1
• Summary: This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this do

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017921	hsa-miR-335-5p	Microarray	18185580
MIRT029554	hsa-miR-26b-5p	Microarray	19088304
MIRT1379587	hsa-miR-1264	CLIP-seq
MIRT1379588	hsa-miR-188-3p	CLIP-seq
MIRT1379589	hsa-miR-3148	CLIP-seq
MIRT1379590	hsa-miR-3659	CLIP-seq
MIRT1379591	hsa-miR-4271	CLIP-seq
MIRT1379592	hsa-miR-4457	CLIP-seq
MIRT1379593	hsa-miR-4693-3p	CLIP-seq
MIRT1379594	hsa-miR-4725-3p	CLIP-seq
MIRT1379595	hsa-miR-4786-5p	CLIP-seq
MIRT1379596	hsa-miR-625	CLIP-seq
MIRT2113395	hsa-miR-4719	CLIP-seq
MIRT2113396	hsa-miR-513b	CLIP-seq
MIRT2336436	hsa-miR-1825	CLIP-seq
MIRT2336437	hsa-miR-586	CLIP-seq
MIRT1379591	hsa-miR-4271	CLIP-seq
MIRT1379593	hsa-miR-4693-3p	CLIP-seq
MIRT1379594	hsa-miR-4725-3p	CLIP-seq
MIRT1379596	hsa-miR-625	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0007218	Process	Neuropeptide signaling pathway	NAS	11499680
GO:0007612	Process	Learning	IEA
GO:0007613	Process	Memory	IEA
GO:0008188	Function	Neuropeptide receptor activity	NAS	11499680
GO:0016020	Component	Membrane	NAS	11499680
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099061	Component	Integral component of postsynaptic density membrane	IBA	21873635
GO:1900452	Process	Regulation of long-term synaptic depression	IEA

Other IDs

• MIM: 606285
• HGNC: 16699
• e!Ensembl: ENSG00000156395

Protein

• UniProt ID: Q9UPU3
• Protein name: VPS10 domain-containing receptor SorCS3
• Protein function: Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localization ofAMPA-type glutamate receptors in the postsynaptic density.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15902	Sortilin-Vps10	228 → 658	Sortilin, neurotensin receptor 3,	Domain
  PF15901	Sortilin_C	660 → 816	Sortilin, neurotensin receptor 3, C-terminal	Domain
  PF00801	PKD	826 → 904	PKD domain	Domain

• Sequence:

  MEAARTERPAGRPGAPLVRTGLLLLSTWVLAGAEITWDATGGPGRPAAPASRPPALSPLS
  PRAVASQWPEELASARRAAVLGRRAGPELLPQQGGGRGGEMQVEAGGTSPAGERRGRGIP
  APAKLGGARRSRRAQPPITQERGDAWATAPADGSRGSRPLAKGSREEVKAPRAGGSAAED
  LRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTY
  EKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSL
  LFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHMEVR
  TTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRRE
  AFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKS
  SRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVH
  CLLPFCSLHLHLQLSENPYSSGRISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNT
  WRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALV
  EAGMETHIMTVFGHFSLRSEWQLVKVDYKSIFSRHCTKEDYQTWHLLNQGEPCVMGERKI
  FKKRKPGAQCALGRDHSGSVVSEPCVCANWDFECDYGYERHGESQCVPAFWYNPASPSKD
  CSLGQSYLNSTGYRRIVSNNCTDGLREKYTAKAQMCPGKAPRGLHVVTTDGRLVAEQGHN
  ATFIILMEEGDLQRTNIQLDFGDGIAVSYANFSPIEDGIKHVYKSAGIFQVTAYAENNLG
  SDTAVLFLHVVCPVEHVHLRVPFVAIRNKEVNISAVVWPSQLGTLTYFWWFGNSTKPLIT
  LDSSISFTFLAEGTDTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPE
  WRKDIGNVIKRALVKVTSVPEDQILIAVFPGLPTSAELFILPPKNLTERRKGNEGDLEQI
  VETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAV
  FLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRV
  IGGIATIANSESTKEIPNCTSV

• Sequence length: 1222

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	26830138
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019	30478444
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203

Unknown
Disease name	Disease term	dbSNP ID	References
Cardiovascular diseases	Cardiovascular Diseases		30595370
Development disorder	Child Development Disorders, Pervasive		30804558
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	29942085, 27479909, 29662059, 30718901, 30804558, 29700475
Mood disorder	Mood Disorders		29942085