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MAPRE1 (microtubule associated protein RP/EB family member 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
22919
Gene nameGene Name - the full gene name approved by the HGNC.
Microtubule associated protein RP/EB family member 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MAPRE1
SynonymsGene synonyms aliases
EB1
ChromosomeChromosome number
20
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q11.21
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. D
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007026 hsa-miR-10b-5p Luciferase reporter assay 21562367
MIRT007026 hsa-miR-10b-5p Luciferase reporter assay 21562367
MIRT023330 hsa-miR-122-5p Microarray 17612493
MIRT027584 hsa-miR-98-5p Microarray 19088304
MIRT049331 hsa-miR-92a-3p Luciferase reporter assay, qRT-PCR 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS
GO:0001578 Process Microtubule bundle formation IEA
GO:0003723 Function RNA binding HDA 22681889
GO:0005515 Function Protein binding IPI 10226031, 10644998, 10773885, 11943150, 15631994, 16455083, 17563362, 17828277, 18477699, 19543227, 19553473, 19632184, 21646404, 21820309, 23574715, 23874158, 24997520, 25225338, 25416956, 26242911, 26485573, 26496610, 26638075, 27107012, 27173435, 28514442, 29162697, 29997244, 315
GO:0005794 Component Golgi apparatus IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q15691
Protein name Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)
Protein function Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:
PDB 1PA7 , 1TXQ , 1UEG , 1VKA , 1WU9 , 1YIB , 1YIG , 2HKQ , 2HL3 , 2HL5 , 2QJZ , 2R8U , 3GJO , 3MTU , 3MUD , 3TQ7 , 4XA1 , 4XA3 , 4XA6 , 5JV3 , 5JVM , 5JVP , 5JVR , 5JVS , 5JVU , 5JX1 , 5WLQ , 6PF2 , 6PFP , 6YF5 , 6YSH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00307 CH
14 120
Calponin homology (CH) domain
Domain
PF03271 EB1
210 248
EB1-like C-terminal motif
Family
Sequence
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKK
VKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYD

GKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQVNVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQ
RIVDILYA
TDEGFVIPDEGGPQEEQEEY
Sequence length 268
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Myocardial ischemia Myocardial Ischemia 16214533
Polycystic ovary syndrome Polycystic Ovary Syndrome 30566500

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