Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
22919 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Microtubule associated protein RP/EB family member 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
MAPRE1 |
SynonymsGene synonyms aliases
|
EB1 |
ChromosomeChromosome number
|
20 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
20q11.21 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. D |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000086 |
Process |
G2/M transition of mitotic cell cycle |
TAS |
|
GO:0001578 |
Process |
Microtubule bundle formation |
IEA |
|
GO:0003723 |
Function |
RNA binding |
HDA |
22681889 |
GO:0005515 |
Function |
Protein binding |
IPI |
10226031, 10644998, 10773885, 11943150, 15631994, 16455083, 17563362, 17828277, 18477699, 19543227, 19553473, 19632184, 21646404, 21820309, 23574715, 23874158, 24997520, 25225338, 25416956, 26242911, 26485573, 26496610, 26638075, 27107012, 27173435, 28514442, 29162697, 29997244, 315 |
GO:0005794 |
Component |
Golgi apparatus |
IEA |
|
GO:0005813 |
Component |
Centrosome |
IDA |
21399614 |
GO:0005815 |
Component |
Microtubule organizing center |
IBA |
21873635 |
GO:0005819 |
Component |
Spindle |
IDA |
11943150 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005874 |
Component |
Microtubule |
IDA |
10773885 |
GO:0005881 |
Component |
Cytoplasmic microtubule |
IBA |
21873635 |
GO:0005925 |
Component |
Focal adhesion |
IDA |
25490267 |
GO:0008022 |
Function |
Protein C-terminus binding |
TAS |
7606712 |
GO:0008104 |
Process |
Protein localization |
TAS |
26323690 |
GO:0010389 |
Process |
Regulation of G2/M transition of mitotic cell cycle |
TAS |
|
GO:0016477 |
Process |
Cell migration |
IMP |
26242911 |
GO:0019901 |
Function |
Protein kinase binding |
IPI |
26323690 |
GO:0030335 |
Process |
Positive regulation of cell migration |
TAS |
|
GO:0030981 |
Component |
Cortical microtubule cytoskeleton |
IDA |
15631994 |
GO:0031110 |
Process |
Regulation of microtubule polymerization or depolymerization |
IBA |
21873635 |
GO:0031115 |
Process |
Negative regulation of microtubule polymerization |
IDA |
11943150 |
GO:0031116 |
Process |
Positive regulation of microtubule polymerization |
IMP |
29162697 |
GO:0031253 |
Component |
Cell projection membrane |
IEA |
|
GO:0035371 |
Component |
Microtubule plus-end |
IBA |
21873635 |
GO:0035372 |
Process |
Protein localization to microtubule |
IDA |
19632184, 21820309 |
GO:0036064 |
Component |
Ciliary basal body |
IEA |
|
GO:0042802 |
Function |
Identical protein binding |
IPI |
25416956, 27107012, 31515488, 32296183 |
GO:0045296 |
Function |
Cadherin binding |
HDA |
25468996 |
GO:0046785 |
Process |
Microtubule polymerization |
IEA |
|
GO:0051010 |
Function |
Microtubule plus-end binding |
IBA |
21873635 |
GO:0051010 |
Function |
Microtubule plus-end binding |
IDA |
15631994, 19632184 |
GO:0051225 |
Process |
Spindle assembly |
IBA |
21873635 |
GO:0051233 |
Component |
Spindle midzone |
IBA |
21873635 |
GO:0051301 |
Process |
Cell division |
IEA |
|
GO:0071539 |
Process |
Protein localization to centrosome |
IEA |
|
GO:0097711 |
Process |
Ciliary basal body-plasma membrane docking |
TAS |
|
GO:1903033 |
Process |
Positive regulation of microtubule plus-end binding |
IEA |
|
GO:1904825 |
Process |
Protein localization to microtubule plus-end |
IBA |
21873635 |
GO:1905515 |
Process |
Non-motile cilium assembly |
IEA |
|
GO:1905721 |
Component |
Mitotic spindle astral microtubule end |
IDA |
23509069 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
Q15691 |
Protein name |
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) |
Protein function |
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed: |
PDB |
1PA7
,
1TXQ
,
1UEG
,
1VKA
,
1WU9
,
1YIB
,
1YIG
,
2HKQ
,
2HL3
,
2HL5
,
2QJZ
,
2R8U
,
3GJO
,
3MTU
,
3MUD
,
3TQ7
,
4XA1
,
4XA3
,
4XA6
,
5JV3
,
5JVM
,
5JVP
,
5JVR
,
5JVS
,
5JVU
,
5JX1
,
5WLQ
,
6PF2
,
6PFP
,
6YF5
,
6YSH
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00307 |
CH |
14 → 120 |
Calponin homology (CH) domain |
Domain |
PF03271 |
EB1 |
210 → 248 |
EB1-like C-terminal motif |
Family |
|
Sequence |
|
Sequence length |
268 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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|
Associated diseases
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Myocardial ischemia |
Myocardial Ischemia |
|
16214533 |
Polycystic ovary syndrome |
Polycystic Ovary Syndrome |
|
30566500 |
|