SBNO2 (strawberry notch homolog 2)

Gene

• Entrez ID: 22904
• Gene name: Strawberry notch homolog 2
• Gene symbol: SBNO2
• Synonyms: KIAA0963, SNO, STNO
• Chromosome: 19
• Chromosome location: 19p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022166	hsa-miR-124-3p	Microarray	18668037
MIRT028257	hsa-miR-32-5p	Sequencing	20371350
MIRT050357	hsa-miR-25-3p	CLASH	23622248
MIRT1327209	hsa-miR-1275	CLIP-seq
MIRT1327210	hsa-miR-153	CLIP-seq
MIRT1327211	hsa-miR-2964a-3p	CLIP-seq
MIRT1327212	hsa-miR-4419a	CLIP-seq
MIRT1327213	hsa-miR-4446-3p	CLIP-seq
MIRT1327214	hsa-miR-448	CLIP-seq
MIRT1327215	hsa-miR-4492	CLIP-seq
MIRT1327216	hsa-miR-4498	CLIP-seq
MIRT1327217	hsa-miR-4505	CLIP-seq
MIRT1327218	hsa-miR-4510	CLIP-seq
MIRT1327219	hsa-miR-4525	CLIP-seq
MIRT1327220	hsa-miR-4665-5p	CLIP-seq
MIRT1327221	hsa-miR-4723-5p	CLIP-seq
MIRT1327222	hsa-miR-4728-5p	CLIP-seq
MIRT1327223	hsa-miR-4731-5p	CLIP-seq
MIRT1327224	hsa-miR-625	CLIP-seq
MIRT1327225	hsa-miR-637	CLIP-seq
MIRT1327226	hsa-miR-762	CLIP-seq
MIRT1327227	hsa-miR-1200	CLIP-seq
MIRT1327228	hsa-miR-125a-5p	CLIP-seq
MIRT1327229	hsa-miR-125b	CLIP-seq
MIRT1327230	hsa-miR-3074-5p	CLIP-seq
MIRT1327231	hsa-miR-3170	CLIP-seq
MIRT1327232	hsa-miR-3663-3p	CLIP-seq
MIRT1327233	hsa-miR-4319	CLIP-seq
MIRT1327234	hsa-miR-4324	CLIP-seq
MIRT1327235	hsa-miR-544b	CLIP-seq
MIRT2097173	hsa-miR-1234	CLIP-seq
MIRT2097174	hsa-miR-124	CLIP-seq
MIRT2097175	hsa-miR-2861	CLIP-seq
MIRT1327211	hsa-miR-2964a-3p	CLIP-seq
MIRT2097176	hsa-miR-3192	CLIP-seq
MIRT1327234	hsa-miR-4324	CLIP-seq
MIRT2097177	hsa-miR-4493	CLIP-seq
MIRT2097178	hsa-miR-4750	CLIP-seq
MIRT2097179	hsa-miR-4792	CLIP-seq
MIRT2097180	hsa-miR-506	CLIP-seq
MIRT1327235	hsa-miR-544b	CLIP-seq
MIRT2097181	hsa-miR-661	CLIP-seq
MIRT2321514	hsa-miR-1225-3p	CLIP-seq
MIRT2321515	hsa-miR-499-3p	CLIP-seq
MIRT2321516	hsa-miR-499a-3p	CLIP-seq
MIRT2394064	hsa-miR-1280	CLIP-seq
MIRT2394065	hsa-miR-4286	CLIP-seq
MIRT2442588	hsa-miR-361-3p	CLIP-seq
MIRT2442589	hsa-miR-4707-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002281	Process	Macrophage activation involved in immune response	IBA	21873635
GO:0002281	Process	Macrophage activation involved in immune response	IMP	18025162
GO:0005575	Component	Cellular_component	ND
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0030282	Process	Bone mineralization	IEA
GO:0030316	Process	Osteoclast differentiation	IBA	21873635
GO:0031490	Function	Chromatin DNA binding	IBA	21873635
GO:0042393	Function	Histone binding	IBA	21873635
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IBA	21873635
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IMP	18025162
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0050727	Process	Regulation of inflammatory response	IBA	21873635
GO:0050727	Process	Regulation of inflammatory response	IMP	18025162
GO:0061430	Process	Bone trabecula morphogenesis	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071348	Process	Cellular response to interleukin-11	ISS
GO:0071354	Process	Cellular response to interleukin-6	IBA	21873635
GO:0071354	Process	Cellular response to interleukin-6	IDA	25903009
GO:0072675	Process	Osteoclast fusion	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	ISS

Other IDs

• MIM: 615729
• HGNC: 29158
• e!Ensembl: ENSG00000064932

Protein

• UniProt ID: Q9Y2G9
• Protein name: Protein strawberry notch homolog 2
• Protein function: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13872	AAA_34	215 → 505	P-loop containing NTP hydrolase pore-1	Domain
  PF13871	Helicase_C_4	732 → 1010	C-terminal domain on Strawberry notch homologue	Domain

• Sequence:

  MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFSLPPYPAFSSDSRPFMS
  SASFLGSQPCPDTSYAPVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDSLSDIVDT
  PDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQS
  QPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLAL
  PSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGR
  KKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQ
  AGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLPLARVVYAS
  ATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQ
  LSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAH
  QRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAA
  EGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESD
  PGLDSDFNSSPESLVDDDVVIVDAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLD
  KVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHV
  NLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGR
  THRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENK
  YGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVE
  KDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYE
  ESQQVFLAPGHPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSC
  LLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHS
  AWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKD
  RKKQVGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLT
  YSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDML
  RSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFSPPFPGAQAPL

• Sequence length: 1366

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738, 31036433, 30929738
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	28067908, 26192919
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	22190364
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22373040

Unknown
Disease name	Disease term	dbSNP ID	References
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	21102463, 23128233, 18587394, 28067908, 26192919, 26974007
Ulcerative colitis	Ulcerative Colitis		26974007