LMTK2 (lemur tyrosine kinase 2)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
22853 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Lemur tyrosine kinase 2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
LMTK2 |
SynonymsGene synonyms aliases
|
AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk, hBREK |
ChromosomeChromosome number
|
7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7q21.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This pro |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
EGR1 |
Activation |
15289351 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001881 |
Process |
Receptor recycling |
IMP |
18029400, 18429820 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IDA |
12393858, 16887929 |
GO:0004714 |
Function |
Transmembrane receptor protein tyrosine kinase activity |
IBA |
21873635 |
GO:0004864 |
Function |
Protein phosphatase inhibitor activity |
IDA |
12393858 |
GO:0005515 |
Function |
Protein binding |
IPI |
12393858, 12832520, 24366813, 26496610, 28065597, 28330616 |
GO:0005524 |
Function |
ATP binding |
NAS |
12393858 |
GO:0005769 |
Component |
Early endosome |
IDA |
18029400, 18429820 |
GO:0005794 |
Component |
Golgi apparatus |
IDA |
12832520 |
GO:0005829 |
Component |
Cytosol |
IEA |
|
GO:0005887 |
Component |
Integral component of plasma membrane |
IBA |
21873635 |
GO:0006468 |
Process |
Protein phosphorylation |
IDA |
12393858 |
GO:0007169 |
Process |
Transmembrane receptor protein tyrosine kinase signaling pathway |
IBA |
21873635 |
GO:0007275 |
Process |
Multicellular organism development |
IBA |
21873635 |
GO:0007409 |
Process |
Axonogenesis |
IBA |
21873635 |
GO:0016021 |
Component |
Integral component of membrane |
IDA |
12393858 |
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
IDA |
16887929 |
GO:0018107 |
Process |
Peptidyl-threonine phosphorylation |
IDA |
16887929 |
GO:0018108 |
Process |
Peptidyl-tyrosine phosphorylation |
IEA |
|
GO:0030426 |
Component |
Growth cone |
IEA |
|
GO:0032456 |
Process |
Endocytic recycling |
IMP |
18029400 |
GO:0032515 |
Process |
Negative regulation of phosphoprotein phosphatase activity |
IEA |
|
GO:0033572 |
Process |
Transferrin transport |
IMP |
18029400, 18429820 |
GO:0033674 |
Process |
Positive regulation of kinase activity |
IBA |
21873635 |
GO:0043025 |
Component |
Neuronal cell body |
IEA |
|
GO:0043235 |
Component |
Receptor complex |
IBA |
21873635 |
GO:0045022 |
Process |
Early endosome to late endosome transport |
IMP |
18429820 |
GO:0046777 |
Process |
Protein autophosphorylation |
IDA |
12393858 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IDA |
12832520, 18429820 |
GO:0055037 |
Component |
Recycling endosome |
IDA |
18029400, 18429820 |
GO:0070853 |
Function |
Myosin VI binding |
IPI |
18029400, 18429820 |
GO:0106310 |
Function |
Protein serine kinase activity |
IEA |
|
GO:0106311 |
Function |
Protein threonine kinase activity |
IEA |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q8IWU2 |
Protein name |
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI |
Protein function |
Phosphorylates PPP1C, phosphorylase b and CFTR. |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF07714 |
PK_Tyr_Ser-Thr |
137 → 407 |
Protein tyrosine and serine/threonine kinase |
Domain |
|
Sequence |
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIV LIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQ FQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQD TFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTM LLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDD KKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLN QVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEV DFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEA AKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVF DAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEES STDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGV QADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELS ENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGL SLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGET QPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESD SVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAK EAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQK LVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGD GHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPV LPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASS PWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPD IEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPI ILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCG GEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSK PSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDG EKD
|
|
Sequence length |
1503 |
Interactions |
View interactions |
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Lung carcinoma |
Large cell carcinoma of lung |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 |
|
Nasopharyngeal carcinoma |
Nasopharyngeal carcinoma |
rs200046052 |
20512145 |
Prostate cancer |
Malignant neoplasm of prostate, Prostate carcinoma |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
18264097, 19767753, 29892016, 19767753, 18264097 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Prostatic neoplasms |
Prostatic Neoplasms |
|
18264097 |
|
|
|
| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412 |