COPG1 (coat protein complex I subunit gamma 1)

Gene

• Entrez ID: 22820
• Gene name: Coat protein complex I subunit gamma 1
• Gene symbol: COPG1
• Synonyms: COPG, IMD128
• Chromosome: 3
• Chromosome location: 3q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017439	hsa-miR-335-5p	Microarray	18185580
MIRT023687	hsa-miR-1-3p	Proteomics	18668040
MIRT023687	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT032263	hsa-let-7b-5p	Proteomics	18668040
MIRT051586	hsa-let-7e-5p	CLASH	23622248
MIRT049305	hsa-miR-92a-3p	CLASH	23622248
MIRT036123	hsa-miR-1296-5p	CLASH	23622248
MIRT440911	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT389726	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440911	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT389726	hsa-miR-142-3p	HITS-CLIP	22473208

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA	21873635
GO:0000139	Component	Golgi membrane	ISS
GO:0000139	Component	Golgi membrane	TAS
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	14527956, 19039328, 25036637
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA	21873635
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS
GO:0006891	Process	Intra-Golgi vesicle-mediated transport	IBA	21873635
GO:0009306	Process	Protein secretion	IBA	21873635
GO:0030126	Component	COPI vesicle coat	IBA	21873635
GO:0030126	Component	COPI vesicle coat	ISS
GO:0030133	Component	Transport vesicle	TAS
GO:0051683	Process	Establishment of Golgi localization	ISS
GO:0072384	Process	Organelle transport along microtubule	IBA	21873635
GO:0072384	Process	Organelle transport along microtubule	ISS

Other IDs

• MIM: 615525
• HGNC: 2236
• e!Ensembl: ENSG00000181789

Protein

• UniProt ID: Q9Y678
• Protein name: Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)
• Protein function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi ne
• PDB: 1R4X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01602	Adaptin_N	23 → 539	Adaptin N terminal region	Family
  PF08752	COP-gamma_platf	611 → 759	Coatomer gamma subunit appendage platform subdomain	Domain
  PF16381	Coatomer_g_Cpla	761 → 873	Coatomer subunit gamma-1 C-terminal appendage platform	Domain

• Sequence:

  MLKKFDKKDEESGGGSNPFQHLEKSAVLQEARVFNETPINPRKCAHILTKILYLINQGEH
  LGTTEATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDVIIVTSSLTKDMTGKEDNY
  RGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNE
  AQEAASSDNIMVQYHALGLLYHVRKNDRLAVNKMISKVTRHGLKSPFAYCMMIRVASKQL
  EEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPK
  AALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRL
  MKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVDC
  IISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKTTNPSKYIRFIYNRV
  VLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDNEVRDRATFYLNVLEQKQK
  ALNAGYILNGLTVSIPGLERALQQYTLEPSEKPFDLKSVPLATAPMAEQRTESTPITAVK
  QPEKVAATRQEIFQEQLAAVPEFRGLGPLFKSSPEPVALTESETEYVIRCTKHTFTNHMV
  FQFDCTNTLNDQTLENVTVQMEPTEAYEVLCYVPARSLPYNQPGTCYTLVALPKEDPTAV
  ACTFSCMMKFTVKDCDPTTGETDDEGYEDEYVLEDLEVTVADHIQKVMKLNFEAAWDEVG
  DEFEKEETFTLSTIKTLEEAVGNIVKFLGMHPCERSDKVPDNKNTHTLLLAGVFRGGHDI
  LVRSRLLLLDTVTMQVTARSLEELPVDIILASVG

• Sequence length: 874

Pathways

Reactome:

COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Malignant mesothelioma	Malignant mesothelioma		26463840