MRAS (muscle RAS oncogene homolog)

Gene

• Entrez ID: 22808
• Gene name: Muscle RAS oncogene homolog
• Gene symbol: MRAS
• Synonyms: M-RAs, NS11, R-RAS3, RRAS3
• Chromosome: 3
• Chromosome location: 3q22.3
• Summary: This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1560171992	G>C	Likely-pathogenic	Missense variant, intron variant, coding sequence variant
rs1576359216	G>T	Pathogenic	Intron variant, missense variant, coding sequence variant
rs1576387876	C>T	Pathogenic, likely-pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs1576387885	A>G	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039529	hsa-miR-652-3p	CLASH	23622248
MIRT443651	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT443652	hsa-miR-95-5p	PAR-CLIP	22100165
MIRT443653	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT473037	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT473038	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT473039	hsa-miR-5192	PAR-CLIP	23592263
MIRT473040	hsa-miR-6069	PAR-CLIP	23592263
MIRT473041	hsa-miR-4644	PAR-CLIP	23592263
MIRT473042	hsa-miR-4306	PAR-CLIP	23592263
MIRT473043	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT473044	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT473044	hsa-miR-3605-5p	PAR-CLIP	27292025
MIRT473045	hsa-miR-2392	PAR-CLIP	23592263
MIRT761210	hsa-miR-1185-5p	PAR-CLIP	27292025
MIRT761738	hsa-miR-1265	PAR-CLIP	27292025
MIRT766736	hsa-miR-3679-5p	PAR-CLIP	27292025
MIRT770934	hsa-miR-4681	PAR-CLIP	27292025
MIRT781776	hsa-miR-7-5p	PAR-CLIP	27292025

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0003924	Function	GTPase activity	IMP	28289718
GO:0005515	Function	Protein binding	IPI	25137548
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0007265	Process	Ras protein signal transduction	IBA	21873635
GO:0007265	Process	Ras protein signal transduction	IMP	28289718
GO:0007275	Process	Multicellular organism development	TAS	10446149
GO:0007517	Process	Muscle organ development	TAS
GO:0019003	Function	GDP binding	IBA	21873635
GO:0030036	Process	Actin cytoskeleton organization	TAS
GO:0030742	Function	GTP-dependent protein binding	IPI	10934204
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

Other IDs

• MIM: 608435
• HGNC: 7227
• e!Ensembl: ENSG00000158186

Protein

• UniProt ID: O14807
• Protein name: Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)
• Protein function: Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	15 → 177	Ras family	Domain

• Sequence:

  MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW
  AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP
  MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP
  EKSQKKKKKTKWRGDRATGTHKLQCVIL

• Sequence length: 208

Pathways

KEGG:

MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Cellular senescence
Apelin signaling pathway
C-type lectin receptor signaling pathway
Regulation of actin cytoskeleton
Proteoglycans in cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hearing loss	Sensorineural Hearing Loss (disorder)	rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359, rs180177151, rs180177154, rs180177153, rs35689081, rs35887622, rs80338944, rs104894396, rs104894398, rs80338947, rs80338948, rs80338942, rs104894402, rs104894403, rs80338945, rs28931594, rs80338940, rs80338941, rs80356590, rs80338950, rs387906706, rs387906707, rs387906708, rs398122848, rs387907016, rs587776894, rs387907088, rs397515411, rs370965183, rs398122930, rs199897298, rs111033187, rs111033448, rs199606180, rs111033284, rs397516413, rs111033305, rs111033220, rs111033256, rs111033297, rs111033253, rs104894408, rs111033295, rs397516874, rs76434661, rs111033335, rs397517323, rs111033247, rs367928692, rs374793617, rs143939430, rs397515605, rs80338939, rs200656442, rs779748859, rs587781261, rs587781262, rs143343083, rs200147906, rs730880338, rs797044491, rs146281367, rs756484720, rs869025593, rs201306709, rs540895576, rs777777359, rs879255246, rs1554358720, rs142498437, rs377145777, rs1057517519, rs779077039, rs952741388, rs1060499797, rs764139009, rs1060499590, rs1064794012, rs1064797115, rs756790858, rs775633137, rs1554952443, rs1554952193, rs782063761, rs1199012623, rs756147087, rs1555648043, rs1555661490, rs1553196233, rs781546107, rs111033190, rs775428246, rs782539587, rs537227442, rs148695069, rs1554835827, rs953422571, rs1554834186, rs1554834161, rs1554835103, rs1554577339, rs1554577402, rs768471577, rs782279338, rs781951909, rs998045226, rs375759781, rs755804651, rs1557458426, rs767797828, rs538027448, rs1559366084, rs367688416, rs1558480402, rs1558490542, rs1559870857, rs1560690591, rs1561299289, rs1562817224, rs1562817529, rs1562822565, rs1562835391, rs1564113368, rs1564554255, rs773851192, rs1564555240, rs761261855, rs1564805114, rs1565522273, rs1565127413, rs781790246, rs1565430886, rs1565469959, rs746667217, rs1565819402, rs1565855932, rs150529554, rs1567939793, rs201866631, rs754472294, rs1559372512, rs1558464965, rs1558488902, rs775062249, rs1226171550, rs1561590396, rs765574676, rs762876554, rs757327146, rs1564949059, rs1565519673, rs368050948, rs1565541888, rs781989117, rs1565402473, rs750358148, rs1386887007, rs1209665716, rs1567641234, rs1237955948, rs1569042782, rs752672077, rs146689036, rs1560070780, rs149712664, rs1564556995, rs762226905, rs773573968, rs1568528171, rs1198256157, rs377267777, rs370564476, rs1577876794, rs747787770, rs759432278, rs1043716893, rs1581138934, rs2033773650, rs1421964916, rs771766431, rs780917129, rs1895773215, rs1895769400, rs761543680, rs1565920060
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs-1, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28869590
Noonan syndrome	Noonan Syndrome, Noonan syndrome	rs121434312, rs267607048, rs121434499, rs113954997, rs104894359, rs104894360, rs104894364, rs104894365, rs104894366, rs104894367, rs193929331, rs28933406, rs104894230, rs104894226, rs104894228, rs137852812, rs137852813, rs137852814, rs267607079, rs267607080, rs121918453, rs121918454, rs28933386, rs121918455, rs121918456, rs121918460, rs121918461, rs121918457, rs121918458, rs121918459, rs121918462, rs121918463, rs121918465, rs121918466, rs121918468, rs121918469, rs121918470, rs80338836, rs267606990, rs121908595, rs267606704, rs121434595, rs11554290, rs121434596, rs267606921, rs267606920, rs80338796, rs121434594, rs80338799, rs80338797, rs180177034, rs121913369, rs180177035, rs121913355, rs180177037, rs180177040, rs387906660, rs606231228, rs397514553, rs121913237, rs397507466, rs397507467, rs121913348, rs397507473, rs397507475, rs180177039, rs397507477, rs397507480, rs121913375, rs397507484, rs727503110, rs730880471, rs121913250, rs397507501, rs397507503, rs397507504, rs397507505, rs397507506, rs397507507, rs397507509, rs397507510, rs397507511, rs397507512, rs397507513, rs397507514, rs397507517, rs397507518, rs397507519, rs397507520, rs397507523, rs397507524, rs397507525, rs397507526, rs376607329, rs397507527, rs397507529, rs397507530, rs397507531, rs397507537, rs397507539, rs397507540, rs397507541, rs397507543, rs397507544, rs397507545, rs397507546, rs397507547, rs397507548, rs397507549, rs397507550, rs397516826, rs727505017, rs3730271, rs397516827, rs397516828, rs397516830, rs397516813, rs730881002, rs730881003, rs397516815, rs730881054, rs397517164, rs397517172, rs397517147, rs397517148, rs727504295, rs397517149, rs730881045, rs397517153, rs397517154, rs727505381, rs397517156, rs574088829, rs397517159, rs397516792, rs397516791, rs397516801, rs397516802, rs397516803, rs397516809, rs397516810, rs397516825, rs397516829, rs397516891, rs397516903, rs397516904, rs397516905, rs397517041, rs397517042, rs397517076, rs397517077, rs397517146, rs397517150, rs397517163, rs397517174, rs397517180, rs397509343, rs672601334, rs672601335, rs587777179, rs587777180, rs483352822, rs587777613, rs202247812, rs121913233, rs727503384, rs121913341, rs180177036, rs180177042, rs121913357, rs727504426, rs727503380, rs727503381, rs727504662, rs727504370, rs727504170, rs727503996, rs730881014, rs267606706, rs121918464, rs869025197, rs869025196, rs869025195, rs869025194, rs869025193, rs869025192, rs869025191, rs869025189, rs869320686, rs797045165, rs797045166, rs869320687, rs797045167, rs864622410, rs869025340, rs869025573, rs869312687, rs876657651, rs886037952, rs886039607, rs886039463, rs777520196, rs886041414, rs189150283, rs868208063, rs1057519732, rs121913496, rs1057519963, rs781431741, rs1135401776, rs1555194026, rs1460026299, rs1553362937, rs1052382672, rs1553196539, rs149850248, rs1398859175, rs761685529, rs1034395178, rs1194536394, rs1555928249, rs750777752, rs1555391053, rs1553610155, rs145594158, rs770933647, rs777243508, rs-1, rs1390048261, rs1223430276, rs1557962794, rs1249726034, rs150419186, rs782457908, rs1591495767, rs1591495776, rs1591495779, rs1576359216, rs1576387876, rs1576387885, rs727505093, rs1601718760, rs1592808357, rs1592798693, rs869025501, rs397507478, rs1572830693, rs1594982548, rs1458682620, rs1571999498, rs1572830219, rs1593351503, rs1592852902, rs1671004485, rs1673399238, rs397507536	28289718, 23875798
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085
Hypogonadotropic hypogonadism	Hypogonadotropic hypogonadism	rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs-1, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Atrial septal defect	Atrial Septal Defects	rs137852951, rs137852953, rs137852955, rs267607106, rs-1, rs104893900, rs104893901, rs104893903, rs606231358, rs606231359, rs137852683, rs606231360, rs104893907, rs104894073, rs1585703301, rs104894074, rs267606903, rs121912677, rs387906585, rs387906773, rs72554028, rs587782928, rs587782929, rs587782930, rs587784067, rs1555226315, rs879253754, rs1114167356, rs773922431, rs1554093487, rs1554093433, rs1554093461, rs1561621507, rs1561619801, rs766692577, rs1581108237, rs1581111034, rs1579663872, rs1583066622, rs1456289029, rs1761430125
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Coronary artery disease	CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1, Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	23202125, 21378990, 24262325, 28714975, 29212778
Coronary heart disease	Coronary heart disease	rs-1	24262325, 21347282, 19198612, 21378990, 28869590
Brachydactyly	Brachydactyly	rs121908949, rs28937580, rs121909082, rs104894122, rs863223289, rs863223290, rs104894121, rs1587657302, rs863223292, rs74315386, rs74315387, rs-1, rs28936397, rs753691079, rs121909348, rs121917852, rs121917853, rs121917854, rs121917855, rs121917859, rs121917861, rs267606873, rs267606872, rs267606985, rs267606986, rs267606987, rs267606988, rs28933082, rs397514519, rs869025613, rs869025614, rs886039878, rs1553540620, rs1057518333, rs1948841937, rs1948868228, rs1948842030, rs1948842142
Noonan-like syndrome with loose anagen hair	Noonan-Like Syndrome With Loose Anagen Hair, Noonan syndrome-like disorder with loose anagen hair	rs267607048, rs730881020, rs886037952, rs886037954, rs886037955, rs1114167429, rs1553311527
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Cardiofaciocutaneous syndrome	Cardio-facio-cutaneous syndrome	rs121434497, rs121434498, rs121434499, rs267607230, rs121913530, rs104894359, rs104894360, rs104894366, rs104894361, rs104894362, rs121908594, rs121908595, rs121908596, rs121913348, rs180177034, rs121913357, rs180177035, rs121913355, rs180177036, rs180177039, rs180177040, rs180177041, rs387906660, rs387906661, rs387906800, rs387907205, rs387907206, rs397507465, rs397507466, rs397507473, rs397507474, rs397507475, rs397507476, rs397507479, rs397507480, rs397507483, rs113488022, rs397507484, rs397516792, rs397516793, rs730880517, rs397516790, rs727504317, rs727504382, rs397516791, rs397516892, rs397516893, rs180177038, rs397516894, rs397516895, rs397516904, rs121913341, rs180177042, rs727504370, rs797044593, rs794729219, rs869025339, rs869025606, rs869025608, rs876657651, rs886041310, rs727504819, rs121913349, rs121913337, rs121913338, rs1057519732, rs1057519733, rs1057519805, rs1057519806, rs1135401787, rs1586126581, rs1586140436, rs1586140512, rs1595860875, rs1599307313, rs2041142587
Nystagmus	Nystagmus	rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896
Costello syndrome	Costello syndrome (disorder)	rs104894230, rs104894229, rs104894226, rs104894227, rs104894228, rs104894231, rs121917756, rs121917757, rs121917758, rs121917759, rs398122808, rs398122809, rs727503093, rs730880460, rs587777239, rs727504747, rs727503094, rs1554884966, rs1589792804
Leopard syndrome	LEOPARD Syndrome	rs28933386, rs121918455, rs121918456, rs121918461, rs121918457, rs121918462, rs121918463, rs121918468, rs121918469, rs121918470, rs267606990, rs80338796, rs80338797, rs180177035, rs387906661, rs397507466, rs397507505, rs397507510, rs397507519, rs376607329, rs397507527, rs397507531, rs397507540, rs397507541, rs397507542, rs397507546, rs397507548, rs397507549, rs397507550, rs397516813, rs397516801, rs397516827, rs727503380, rs1575573330
Moyamoya disease	Arterial Diseases, Common Carotid	rs121434527, rs121434528, rs387906592, rs397514563, rs797045187, rs1555675538, rs1568149971, rs1599150380, rs-1, rs2079443410	19198612
Cystic hygroma	Lymphangioma, Cystic	rs-1
Radioulnar synostosis	Radioulnar Synostosis	rs1595756416, rs1595756703, rs1231501584, rs1595756962, rs1595757203, rs1595763070, rs1595766210

Unknown
Disease name	Disease term	dbSNP ID	References
Ptosis	Blepharoptosis, Ptosis	rs139920573
Abnormal dermatoglyphic pattern	Abnormal dermatoglyphic pattern
Camptodactyly of fingers	Clinodactyly of the 5th finger
Cardiovascular diseases	Cardiovascular Diseases		30595370
Carotid artery disease	Carotid Artery Diseases, External Carotid Artery Diseases, Internal Carotid Artery Diseases		19198612
Carotid atherosclerosis	Carotid Atherosclerosis		19198612
Congenital pectus carinatum	Congenital pectus carinatum
Congenital pectus excavatum	Congenital pectus excavatum
Coronary arteriosclerosis	Coronary Arteriosclerosis		21378990
Dwarfism	Dwarfism
Dysarthria	Dysarthria
High palate	Byzanthine arch palate
Melanocytic nevus	Melanocytic nevus
Micrognathism	Micrognathism
Neck webbing	Neck webbing
Posteriorly rotated ear	Posteriorly rotated ear
Proptosis	Exophthalmos
Pulmonary stenosis	Pulmonary Stenosis
Strabismus	Strabismus