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IKZF3 (IKAROS family zinc finger 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
22806
Gene nameGene Name - the full gene name approved by the HGNC.
IKAROS family zinc finger 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
IKZF3
SynonymsGene synonyms aliases
AIO, AIOLOS, IMD84, ZNFN1A3
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12-q21.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene prod
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT054201 hsa-miR-125b-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22723551
MIRT681314 hsa-miR-890 HITS-CLIP 23706177
MIRT511400 hsa-miR-4695-5p HITS-CLIP 23706177
MIRT511399 hsa-miR-4779 HITS-CLIP 23706177
MIRT511398 hsa-miR-3929 HITS-CLIP 23706177
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IEA
GO:0003700 Function DNA-binding transcription factor activity IBA 21873635
GO:0005515 Function Protein binding IPI 10369681, 11714801, 17646674, 20676092, 21516116, 24722188, 25416956, 25910212, 26871637, 27107012, 28514442, 29892012, 31515488, 32296183
GO:0005634 Component Nucleus IDA 10369681, 17646674
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9UKT9
Protein name Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)
Protein function Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 ex
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2
146 168
Zinc finger, C2H2 type
Domain
PF00096 zf-C2H2
202 223
Zinc finger, C2H2 type
Domain
Sequence
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKV
KDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNC
DVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCN
YACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAE
ARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQ
TRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELE
KKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKE
VPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPF
ECNMCGYRSHDRYEFSSHIARGEHRALLK
Sequence length 509
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma, Childhood asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 24388013, 25256354, 24406073, 30787307, 28461288, 20860503, 21804549, 26542096, 17611496
Dermatitis Dermatitis, Atopic rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 26542096
Esophagus neoplasm Esophageal Neoplasms rs28934578, rs121918714, rs1567556006, rs1575166666 22960999
Immunoglobulin a deficiency Immunoglobulin A deficiency (disorder) rs72553883, rs72553882, rs144718007 27723758
Unknown
Disease name Disease term dbSNP ID References
Lymphocytic leukemia B-CELL MALIGNANCY, LOW-GRADE, B-cell chronic lymphocytic leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma 26466571
B-cell lymphoma Marginal Zone B-Cell Lymphoma 31407831
Biliary cirrhosis Biliary cirrhosis, Primary biliary cirrhosis 20639880, 23000144, 30643196, 20639880, 23000144, 22936693, 22961000, 26394269, 28425483, 28062665
Digestive system neuroendocrine neoplasm Gastro-enteropancreatic neuroendocrine tumor 29915428

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