IKZF3 (IKAROS family zinc finger 3)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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22806 |
Gene nameGene Name - the full gene name approved by the HGNC.
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IKAROS family zinc finger 3 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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IKZF3 |
SynonymsGene synonyms aliases
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AIO, AIOLOS, IMD84, ZNFN1A3 |
ChromosomeChromosome number
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17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q12-q21.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene prod |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0001228 |
Function |
DNA-binding transcription activator activity, RNA polymerase II-specific |
IEA |
|
GO:0003700 |
Function |
DNA-binding transcription factor activity |
IBA |
21873635 |
GO:0005515 |
Function |
Protein binding |
IPI |
10369681, 11714801, 17646674, 20676092, 21516116, 24722188, 25416956, 25910212, 26871637, 27107012, 28514442, 29892012, 31515488, 32296183 |
GO:0005634 |
Component |
Nucleus |
IDA |
10369681, 17646674 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
10369681, 17646674 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0007498 |
Process |
Mesoderm development |
TAS |
10552935 |
GO:0009617 |
Process |
Response to bacterium |
IEA |
|
GO:0030888 |
Process |
Regulation of B cell proliferation |
ISS |
|
GO:0042113 |
Process |
B cell activation |
IEA |
|
GO:0042802 |
Function |
Identical protein binding |
IPI |
25416956, 32296183 |
GO:0042803 |
Function |
Protein homodimerization activity |
IDA |
17646674 |
GO:0042826 |
Function |
Histone deacetylase binding |
IPI |
17646674 |
GO:0042981 |
Process |
Regulation of apoptotic process |
IMP |
10369681 |
GO:0043565 |
Function |
Sequence-specific DNA binding |
ISS |
|
GO:0045577 |
Process |
Regulation of B cell differentiation |
ISS |
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GO:0045619 |
Process |
Regulation of lymphocyte differentiation |
ISS |
|
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IEA |
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:1990841 |
Function |
Promoter-specific chromatin binding |
IDA |
17646674 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q9UKT9 |
Protein name |
Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) |
Protein function |
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 ex |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00096 |
zf-C2H2 |
146 → 168 |
Zinc finger, C2H2 type |
Domain |
PF00096 |
zf-C2H2 |
202 → 223 |
Zinc finger, C2H2 type |
Domain |
|
Sequence |
MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKV KDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNC DVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCN YACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAE ARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQ TRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELE KKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKE VPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPF ECNMCGYRSHDRYEFSSHIARGEHRALLK
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Sequence length |
509 |
Interactions |
View interactions |
Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Asthma |
Asthma, Childhood asthma |
rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 |
24388013, 25256354, 24406073, 30787307, 28461288, 20860503, 21804549, 26542096, 17611496 |
Dermatitis |
Dermatitis, Atopic |
rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 |
26542096 |
Esophagus neoplasm |
Esophageal Neoplasms |
rs28934578, rs121918714, rs1567556006, rs1575166666 |
22960999 |
Immunoglobulin a deficiency |
Immunoglobulin A deficiency (disorder) |
rs72553883, rs72553882, rs144718007 |
27723758 |
Lymphoblastic leukemia |
Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma |
rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591 |
23334668 |
Rheumatoid arthritis |
Rheumatoid Arthritis |
rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 |
23143596 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Lymphocytic leukemia |
B-CELL MALIGNANCY, LOW-GRADE, B-cell chronic lymphocytic leukemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma |
|
26466571 |
B-cell lymphoma |
Marginal Zone B-Cell Lymphoma |
|
31407831 |
Biliary cirrhosis |
Biliary cirrhosis, Primary biliary cirrhosis |
|
20639880, 23000144, 30643196, 20639880, 23000144, 22936693, 22961000, 26394269, 28425483, 28062665 |
Digestive system neuroendocrine neoplasm |
Gastro-enteropancreatic neuroendocrine tumor |
|
29915428 |
Lupus erythematosus |
Lupus Erythematosus, Systemic |
|
26502338, 31407831 |
Polycystic ovary syndrome |
Polycystic Ovary Syndrome |
|
30343302 |
Selective immunoglobulin a deficiency |
Selective immunoglobulin A deficiency |
|
27723758 |
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