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FGL1 (fibrinogen like 1)
Gene
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2267
Gene nameGene Name - the full gene name approved by the HGNC.
Fibrinogen like 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
FGL1
SynonymsGene synonyms aliases
HFREP1, HP-041, HPS, LFIRE-1, LFIRE1
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p22
SummarySummary of gene provided in NCBI Entrez Gene.
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, thi
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Transcription factor Regulation Reference
STAT3 Unknown 19304666
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0005102 Function Signaling receptor binding IBA 21873635
GO:0005515 Function Protein binding IPI 30580966
GO:0005576 Component Extracellular region IDA 30580966
GO:0005577 Component Fibrinogen complex TAS 8390249
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Q08830
Protein name Fibrinogen-like protein 1 (HP-041) (Hepassocin) (HPS) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1)
Protein function Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MH
PDB 7TZ2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00147 Fibrinogen_C
79 → 305
Fibrinogen beta and gamma chains, C-terminal globular domain
 Domain
Sequence
Sequence length 312
Interactions View interactions
Associated diseases
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Causal
Disease name Disease term dbSNP ID References
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 26503814

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