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GPC5 (glypican 5)

Gene

Glypican 5

GPC5

13q31.3

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protei

Show/Hide all(132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT438314	hsa-miR-217	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26098560
MIRT438314	hsa-miR-217	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26098560
MIRT438314	hsa-miR-217	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26098560
MIRT438314	hsa-miR-217	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26098560
MIRT657706	hsa-miR-548ac	HITS-CLIP	23824327
MIRT657705	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT657704	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT657703	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT657702	hsa-miR-548z	HITS-CLIP	23824327
MIRT449572	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT449571	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT449570	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT449569	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT449568	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT449567	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT449566	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT657701	hsa-miR-4637	HITS-CLIP	23824327
MIRT657700	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT657699	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT657697	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT657698	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT657696	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT657695	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT625757	hsa-miR-5193	HITS-CLIP	23824327
MIRT625753	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT625752	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT625751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625759	hsa-miR-1470	HITS-CLIP	23824327
MIRT625758	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT625757	hsa-miR-5193	HITS-CLIP	23824327
MIRT625756	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT625755	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT625754	hsa-miR-4469	HITS-CLIP	23824327
MIRT625753	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT625751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625750	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT625759	hsa-miR-1470	HITS-CLIP	23824327
MIRT625758	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT625757	hsa-miR-5193	HITS-CLIP	23824327
MIRT625756	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT625755	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT625754	hsa-miR-4469	HITS-CLIP	23824327
MIRT625753	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT625752	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT625751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625750	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT449572	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT449571	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT449570	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT449569	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT449568	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT449567	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT449566	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT449565	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449564	hsa-miR-3133	PAR-CLIP	22100165
MIRT449563	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT449562	hsa-miR-20a-3p	PAR-CLIP	22100165
MIRT449561	hsa-miR-190a-5p	PAR-CLIP	22100165
MIRT449560	hsa-miR-190b	PAR-CLIP	22100165
MIRT732315	hsa-miR-297	Luciferase reporter assay, qRT-PCR, Western blot	27554041
MIRT732315	hsa-miR-297	Luciferase reporter assay, qRT-PCR, Western blot	27554041
MIRT657706	hsa-miR-548ac	HITS-CLIP	23824327
MIRT657705	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT657704	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT657703	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT657702	hsa-miR-548z	HITS-CLIP	23824327
MIRT449572	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT449571	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT449570	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT449569	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT449568	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT449567	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT449566	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT657701	hsa-miR-4637	HITS-CLIP	23824327
MIRT657700	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT657699	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT657697	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT657698	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT657696	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT657695	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT625757	hsa-miR-5193	HITS-CLIP	23824327
MIRT625753	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT625752	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT625751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625759	hsa-miR-1470	HITS-CLIP	23824327
MIRT625758	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT625757	hsa-miR-5193	HITS-CLIP	23824327
MIRT625756	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT625755	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT625754	hsa-miR-4469	HITS-CLIP	23824327
MIRT625753	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT625751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625750	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT625759	hsa-miR-1470	HITS-CLIP	23824327
MIRT625758	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT625757	hsa-miR-5193	HITS-CLIP	23824327
MIRT625756	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT625755	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT625754	hsa-miR-4469	HITS-CLIP	23824327
MIRT625753	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT625752	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT625751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625750	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT449572	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT449571	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT449570	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT449569	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT449568	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT449567	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT449566	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT449565	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449564	hsa-miR-3133	PAR-CLIP	22100165
MIRT449563	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT449562	hsa-miR-20a-3p	PAR-CLIP	22100165
MIRT449561	hsa-miR-190a-5p	PAR-CLIP	22100165
MIRT449560	hsa-miR-190b	PAR-CLIP	22100165
MIRT1028608	hsa-miR-1253	CLIP-seq
MIRT1028609	hsa-miR-200b	CLIP-seq
MIRT1028610	hsa-miR-200c	CLIP-seq
MIRT1028611	hsa-miR-2467-3p	CLIP-seq
MIRT1028612	hsa-miR-3653	CLIP-seq
MIRT1028613	hsa-miR-3658	CLIP-seq
MIRT1028614	hsa-miR-3678-3p	CLIP-seq
MIRT1028615	hsa-miR-429	CLIP-seq
MIRT1028616	hsa-miR-4418	CLIP-seq
MIRT1028617	hsa-miR-4436a	CLIP-seq
MIRT1028618	hsa-miR-452	CLIP-seq
MIRT1028619	hsa-miR-4676-3p	CLIP-seq
MIRT1028620	hsa-miR-509-3-5p	CLIP-seq
MIRT1028621	hsa-miR-509-5p	CLIP-seq
MIRT1028622	hsa-miR-548ag	CLIP-seq
MIRT1028623	hsa-miR-548ai	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0006027	Process	Glycosaminoglycan catabolic process	TAS
GO:0009986	Component	Cell surface	IBA	21873635
GO:0016021	Component	Integral component of membrane	TAS	7657705
GO:0016477	Process	Cell migration	IBA	21873635
GO:0043202	Component	Lysosomal lumen	TAS
GO:0046658	Component	Anchored component of plasma membrane	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA	21873635
GO:1905475	Process	Regulation of protein localization to membrane	IBA	21873635

MIM	HGNC	e!Ensembl
602446	4453	ENSG00000179399

Protein

UniProt ID

P78333

Protein name

Glypican-5 [Cleaved into: Secreted glypican-5]

Protein function

Cell surface proteoglycan that bears heparan sulfate.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01153	Glypican	12 → 570	Glypican	Family

Sequence

MDAQTWPVGFRCLLLLALVGSARSEGVQTCEEVRKLFQWRLLGAVRGLPDSPRAGPDLQV
CISKKPTCCTRKMEERYQIAARQDMQQFLQTSSSTLKFLISRNAAAFQETLETLIKQAEN
YTSILFCSTYRNMALEAAASVQEFFTDVGLYLFGADVNPEEFVNRFFDSLFPLVYNHLIN
PGVTDSSLEYSECIRMARRDVSPFGNIPQRVMGQMGRSLLPSRTFLQALNLGIEVINTTD
YLHFSKECSRALLKMQYCPHCQGLALTKPCMGYCLNVMRGCLAHMAELNPHWHAYIRSLE
ELSDAMHGTYDIGHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRPVRTPTQSPRCSF
DQSKEKHGMKTTTRNSEETLANRRKEFINSLRLYRSFYGGLADQLCANELAAADGLPCWN
GEDIVKSYTQRVVGNGIKAQSGNPEVKVKGIDPVINQIIDKLKHVVQLLQGRSPKPDKWE
LLQLGSGGGMVEQVSGDCDDEDGCGGSGSGEVKRTLKITDWMPDDMNFSDVKQIHQTDTG
STLDTTGAGCAVATESMTFTLISVVMLLPGIW

Sequence length

572

Interactions

View interactions

	Reactome
			A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Release of Hh-Np from the secreting cell Retinoid metabolism and transport

Associated diseases

Show/Hide Causal Diseases (5)

Causal
Disease name	Disease term	dbSNP ID	References
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	19010793
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Nephrotic syndrome	Nephrotic Syndrome	rs876657369, rs121912601, rs121912602, rs876657370, rs121912603, rs121912604, rs121912605, rs121907900, rs121907901, rs28941778, rs587776576, rs28942089, rs587776577, rs28941777, rs121907910, rs1568296260, rs119473033, rs74315342, rs74315343, rs74315345, rs74315346, rs74315347, rs74315348, rs121434394, rs267606919, rs121912488, rs267606953, rs267606954, rs267606955, rs104886210, rs1591732280, rs1591750243, rs140511594, rs140781106, rs147972030, rs587776969, rs386833863, rs386833880, rs386833882, rs386833892, rs386833895, rs386833909, rs386833911, rs386833920, rs386833935, rs386833947, rs1555763603, rs398122978, rs398122979, rs398122980, rs369573693, rs398122981, rs398122982, rs398122983, rs200482683, rs730882194, rs180177201, rs587777552, rs587777553, rs775170915, rs749740335, rs12568913, rs530318579, rs786204583, rs786204708, rs786204632, rs138656762, rs797044992, rs797044994, rs797044995, rs864321632, rs864321687, rs864321688, rs864321633, rs869025495, rs869025541, rs869312747, rs145473779, rs757674160, rs869320695, rs138909849, rs869312984, rs1057516900, rs763818901, rs199506378, rs1057517164, rs1057516523, rs1057516414, rs778055996, rs1057516395, rs1057516747, rs1057516880, rs1057516680, rs778217926, rs1057519347, rs764587648, rs1060499703, rs121907903, rs769259446, rs1131692252, rs1131692253, rs1131692254, rs1131692255, rs1131692256, rs746887949, rs1131692235, rs1135402911, rs1135402912, rs1135402913, rs1554946480, rs1555331969, rs773173317, rs1555816634, rs775006954, rs1320543506, rs534522842, rs1272948499, rs1191455921, rs1291398331, rs1554939785, rs776016942, rs1031744496, rs748812981, rs755972674, rs1553312833, rs967339926, rs1462028977, rs1212702104, rs1167223941, rs762631237, rs1553316575, rs1553315173, rs1553316648, rs1553316611, rs780761368, rs368572297, rs1568070817, rs1321552081, rs1558108130, rs1558091788, rs1565707103, rs1558355124, rs1564622701, rs1351580598, rs1589475328, rs1589413498, rs1572255744, rs1572262824, rs761410195, rs1602413491, rs1590326226, rs375998390, rs570583897, rs369363545, rs201488687, rs1334894971, rs763782471, rs138047529, rs895782232, rs1572255047, rs1589433172, rs1589509476, rs1572277600, rs1572282458, rs1584675898, rs759043857, rs1853443391	21441931
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	30423114
Tetralogy of fallot	Tetralogy of Fallot	rs28939668, rs727504412, rs864321649, rs774966208, rs876660981, rs886044220, rs1114167357, rs1569484126, rs1569484164, rs1569484122, rs1569484124, rs1569484042, rs1569484120, rs1569484299, rs1569484301, rs1569484288	23297363

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