DAGLB (diacylglycerol lipase beta)

Gene

• Entrez ID: 221955
• Gene name: Diacylglycerol lipase beta
• Gene symbol: DAGLB
• Synonyms: DAGLBETA, KCCR13L
• Chromosome: 7
• Chromosome location: 7p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016573	hsa-miR-193b-3p	Proteomics	21512034
MIRT045074	hsa-miR-186-5p	CLASH	23622248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001516	Process	Prostaglandin biosynthetic process	ISS
GO:0004806	Function	Triglyceride lipase activity	ISS	31991095
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005886	Component	Plasma membrane	IDA	14610053
GO:0005886	Component	Plasma membrane	TAS
GO:0007216	Process	G protein-coupled glutamate receptor signaling pathway	IBA	21873635
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0010898	Process	Positive regulation of triglyceride catabolic process	ISS	31991095
GO:0016021	Component	Integral component of membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016298	Function	Lipase activity	IDA	14610053
GO:0019369	Process	Arachidonic acid metabolic process	IDA	14610053
GO:0022008	Process	Neurogenesis	IBA	21873635
GO:0042136	Process	Neurotransmitter biosynthetic process	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0071926	Process	Endocannabinoid signaling pathway	IBA	21873635
GO:0098921	Process	Retrograde trans-synaptic signaling by endocannabinoid	IBA	21873635

Other IDs

• MIM: 614016
• HGNC: 28923
• e!Ensembl: ENSG00000164535

Protein

• UniProt ID: Q8NCG7
• Protein name: Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.-) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
• Protein function: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01764	Lipase_3	370 → 505	Lipase (class 3)	Family

• Sequence:

  MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLI
  VLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVA
  DGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQ
  LLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLA
  LLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPL
  TGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLV
  ALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI
  NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQ
  EYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNP
  NNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQ
  EEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVS
  CPAQGVSSVDVA

• Sequence length: 672

Pathways

KEGG:

Retrograde endocannabinoid signaling
Aldosterone synthesis and secretion

Reactome:

Arachidonate production from DAG

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778