Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
221937 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Forkhead box K1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
FOXK1 |
SynonymsGene synonyms aliases
|
FOXK1L |
ChromosomeChromosome number
|
7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7p22.1 |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000122 |
Process |
Negative regulation of transcription by RNA polymerase II |
IEA |
|
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000976 |
Function |
Transcription regulatory region sequence-specific DNA binding |
IDA |
17670796, 25402684, 29861159 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
IBA |
21873635 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
|
GO:0001227 |
Function |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
IDA |
17670796, 25402684 |
GO:0001678 |
Process |
Cellular glucose homeostasis |
IDA |
29861159, 30700909 |
GO:0003700 |
Function |
DNA-binding transcription factor activity |
IDA |
29861159, 30700909 |
GO:0005515 |
Function |
Protein binding |
IPI |
17670796, 21903422, 25402684, 25451922, 25609649, 28514442 |
GO:0005634 |
Component |
Nucleus |
IDA |
25402684, 29861159 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
25402684, 29861159 |
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0007517 |
Process |
Muscle organ development |
IEA |
|
GO:0010507 |
Process |
Negative regulation of autophagy |
IDA |
25402684 |
GO:0010906 |
Process |
Regulation of glucose metabolic process |
IDA |
29861159, 30700909 |
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0016579 |
Process |
Protein deubiquitination |
TAS |
|
GO:0030154 |
Process |
Cell differentiation |
IEA |
|
GO:0042594 |
Process |
Response to starvation |
IDA |
25402684 |
GO:0045892 |
Process |
Negative regulation of transcription, DNA-templated |
IDA |
17670796, 25402684 |
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IDA |
29861159, 30700909 |
GO:0061621 |
Process |
Canonical glycolysis |
IDA |
30700909 |
GO:0071889 |
Function |
14-3-3 protein binding |
IPI |
29861159 |
GO:1990837 |
Function |
Sequence-specific double-stranded DNA binding |
IDA |
28473536 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P85037 |
Protein name |
Forkhead box protein K1 (Myocyte nuclear factor) (MNF) |
Protein function |
Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can bot |
PDB |
8BZM
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00498 |
FHA |
123 → 193 |
FHA domain |
Family |
PF00250 |
Forkhead |
304 → 390 |
Forkhead domain |
Domain |
|
Sequence |
|
Sequence length |
733 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
|
|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Hypothyroidism |
Hypothyroidism |
rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605 |
30595370 |
|