FGD2 (FYVE, RhoGEF and PH domain containing 2)

Gene

• Entrez ID: 221472
• Gene name: FYVE, RhoGEF and PH domain containing 2
• Gene symbol: FGD2
• Synonyms: ZFYVE4
• Chromosome: 6
• Chromosome location: 6p21.2
• Summary: The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocyt

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017089	hsa-miR-335-5p	Microarray	18185580
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT995193	hsa-miR-142-3p	CLIP-seq
MIRT995194	hsa-miR-2113	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT995199	hsa-miR-3174	CLIP-seq
MIRT995200	hsa-miR-3197	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT995209	hsa-miR-3940-3p	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995211	hsa-miR-4432	CLIP-seq
MIRT995212	hsa-miR-4453	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT995216	hsa-miR-4538	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT995218	hsa-miR-4716-5p	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995220	hsa-miR-4797-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT995223	hsa-miR-499-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT995225	hsa-miR-921	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995090	hsa-miR-24	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995200	hsa-miR-3197	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT1995097	hsa-miR-3929	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT1995099	hsa-miR-4284	CLIP-seq
MIRT1995100	hsa-miR-4419b	CLIP-seq
MIRT1995101	hsa-miR-4478	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT1995103	hsa-miR-4649-3p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT1995105	hsa-miR-890	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT2229194	hsa-miR-4786-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT2229195	hsa-miR-769-5p	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT2449656	hsa-miR-3667-5p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT2449656	hsa-miR-3667-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT2532804	hsa-miR-4300	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT2532805	hsa-miR-920	CLIP-seq
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT2532804	hsa-miR-4300	CLIP-seq
MIRT995211	hsa-miR-4432	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995220	hsa-miR-4797-5p	CLIP-seq
MIRT995223	hsa-miR-499-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT2532805	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	ISS
GO:0005794	Component	Golgi apparatus	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007010	Process	Cytoskeleton organization	IBA	21873635
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008360	Process	Regulation of cell shape	ISS
GO:0030027	Component	Lamellipodium	ISS
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0031267	Function	Small GTPase binding	ISS
GO:0031901	Component	Early endosome membrane	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0043065	Process	Positive regulation of apoptotic process	TAS
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0043507	Process	Positive regulation of JUN kinase activity	IEA
GO:0046847	Process	Filopodium assembly	IBA	21873635
GO:0046847	Process	Filopodium assembly	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:1901981	Function	Phosphatidylinositol phosphate binding	IEA

Other IDs

• MIM: 605091
• HGNC: 3664
• e!Ensembl: ENSG00000146192

Protein

• UniProt ID: Q7Z6J4
• Protein name: FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)
• Protein function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, pho
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	106 → 288	RhoGEF domain	Domain
  PF00169	PH	320 → 418	PH domain	Domain
  PF01363	FYVE	453 → 518	FYVE zinc finger	Domain
  PF00169	PH	528 → 641	PH domain	Domain

• Sequence:

  MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA
  VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR
  LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP
  RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH
  HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL
  WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA
  QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI
  EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH
  CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA
  TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT
  VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD

• Sequence length: 655

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	30595370

Unknown
Disease name	Disease term	dbSNP ID	References
Corpus luteum cyst	Corpus Luteum Cyst		21239663
Eczema	Eczema		30595370
Ovarian cysts	Ovarian Cysts		21239663