SKA3 (spindle and kinetochore associated complex subunit 3)

Gene

• Entrez ID: 221150
• Gene name: Spindle and kinetochore associated complex subunit 3
• Gene symbol: SKA3
• Synonyms: C13orf3, RAMA1
• Chromosome: 13
• Chromosome location: 13q12.11
• Summary: This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromos

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052469	hsa-let-7a-5p	CLASH	23622248
MIRT041438	hsa-miR-193b-3p	CLASH	23622248
MIRT739086	hsa-miR-148b	HITS-CLIP	33718276
MIRT739088	hsa-miR-148a	HITS-CLIP	33718276
MIRT1350847	hsa-miR-1206	CLIP-seq
MIRT1350848	hsa-miR-1207-5p	CLIP-seq
MIRT1350849	hsa-miR-1263	CLIP-seq
MIRT1350850	hsa-miR-1272	CLIP-seq
MIRT739104	hsa-miR-127-5p	CLIP-seq
MIRT1350851	hsa-miR-128	CLIP-seq
MIRT1350852	hsa-miR-1322	CLIP-seq
MIRT1350853	hsa-miR-133a	CLIP-seq
MIRT1350854	hsa-miR-133b	CLIP-seq
MIRT1350855	hsa-miR-1470	CLIP-seq
MIRT1350856	hsa-miR-1827	CLIP-seq
MIRT1350857	hsa-miR-203	CLIP-seq
MIRT1350858	hsa-miR-2053	CLIP-seq
MIRT1350859	hsa-miR-27a	CLIP-seq
MIRT1350860	hsa-miR-27b	CLIP-seq
MIRT1350861	hsa-miR-3064-5p	CLIP-seq
MIRT1350862	hsa-miR-3189-3p	CLIP-seq
MIRT1350863	hsa-miR-320a	CLIP-seq
MIRT1350864	hsa-miR-320b	CLIP-seq
MIRT1350865	hsa-miR-320c	CLIP-seq
MIRT1350866	hsa-miR-320d	CLIP-seq
MIRT1350867	hsa-miR-320e	CLIP-seq
MIRT1350868	hsa-miR-326	CLIP-seq
MIRT1350869	hsa-miR-330-5p	CLIP-seq
MIRT1350870	hsa-miR-3652	CLIP-seq
MIRT1350871	hsa-miR-3662	CLIP-seq
MIRT1350872	hsa-miR-3908	CLIP-seq
MIRT1350873	hsa-miR-3938	CLIP-seq
MIRT1350874	hsa-miR-3942-5p	CLIP-seq
MIRT1350875	hsa-miR-409-3p	CLIP-seq
MIRT1350876	hsa-miR-4422	CLIP-seq
MIRT1350877	hsa-miR-4429	CLIP-seq
MIRT1350878	hsa-miR-4430	CLIP-seq
MIRT1350879	hsa-miR-4487	CLIP-seq
MIRT1350880	hsa-miR-4505	CLIP-seq
MIRT1350881	hsa-miR-4506	CLIP-seq
MIRT739100	hsa-miR-4514	CLIP-seq
MIRT1350882	hsa-miR-4639-3p	CLIP-seq
MIRT739103	hsa-miR-4645-5p	CLIP-seq
MIRT739099	hsa-miR-4660	CLIP-seq
MIRT1350883	hsa-miR-4667-3p	CLIP-seq
MIRT739102	hsa-miR-4673	CLIP-seq
MIRT739101	hsa-miR-4692	CLIP-seq
MIRT1350884	hsa-miR-4703-5p	CLIP-seq
MIRT1350885	hsa-miR-4716-3p	CLIP-seq
MIRT1350886	hsa-miR-4738-3p	CLIP-seq
MIRT1350887	hsa-miR-4763-3p	CLIP-seq
MIRT1350888	hsa-miR-511	CLIP-seq
MIRT1350889	hsa-miR-513a-5p	CLIP-seq
MIRT739098	hsa-miR-516b	CLIP-seq
MIRT1350890	hsa-miR-545	CLIP-seq
MIRT1350891	hsa-miR-569	CLIP-seq
MIRT1350892	hsa-miR-593	CLIP-seq
MIRT1350893	hsa-miR-642a	CLIP-seq
MIRT1350894	hsa-miR-646	CLIP-seq
MIRT1350895	hsa-miR-656	CLIP-seq
MIRT1350896	hsa-miR-7	CLIP-seq
MIRT1350897	hsa-miR-885-3p	CLIP-seq
MIRT1350898	hsa-miR-940	CLIP-seq
MIRT2103941	hsa-miR-3607-5p	CLIP-seq
MIRT2103942	hsa-miR-3689a-5p	CLIP-seq
MIRT2103943	hsa-miR-3689b	CLIP-seq
MIRT2103944	hsa-miR-3689e	CLIP-seq
MIRT2103945	hsa-miR-3689f	CLIP-seq
MIRT2103946	hsa-miR-4520a-3p	CLIP-seq
MIRT739089	hsa-miR-132	CLIP-seq
MIRT739087	hsa-miR-152	CLIP-seq
MIRT739090	hsa-miR-212	CLIP-seq
MIRT1350874	hsa-miR-3942-5p	CLIP-seq
MIRT2459434	hsa-miR-4452	CLIP-seq
MIRT1350884	hsa-miR-4703-5p	CLIP-seq
MIRT1350890	hsa-miR-545	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IBA	21873635
GO:0000278	Process	Mitotic cell cycle	IMP	19289083
GO:0000776	Component	Kinetochore	IDA	20813266
GO:0000940	Component	Condensed chromosome outer kinetochore	IBA	21873635
GO:0000940	Component	Condensed chromosome outer kinetochore	IDA	19289083
GO:0005515	Function	Protein binding	IPI	19289083, 19360002, 26496610, 28514442, 31515488, 32296183
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005876	Component	Spindle microtubule	IBA	21873635
GO:0005876	Component	Spindle microtubule	IDA	19289083
GO:0007059	Process	Chromosome segregation	IBA	21873635
GO:0007059	Process	Chromosome segregation	IMP	19289083
GO:0031110	Process	Regulation of microtubule polymerization or depolymerization	IDA	19289083
GO:0051301	Process	Cell division	IEA
GO:0072686	Component	Mitotic spindle	IDA

Other IDs

• MIM: 619247
• HGNC: 20262
• e!Ensembl: ENSG00000165480

Protein

• UniProt ID: Q8IX90
• Protein name: Spindle and kinetochore-associated protein 3
• Protein function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinet
• PDB: 4AJ5
• Sequence:

  MDPIRSFCGKLRSLASTLDCETARLQRALDGEESDFEDYPMRILYDLHSEVQTLKDDVNI
  LLDKARLENQEGIDFIKATKVLMEKNSMDIMKIREYFQKYGYSPRVKKNSVHEQEAINSD
  PELSNCENFQKTDVKDDLSDPPVASSCISEKSPRSPQLSDFGLERYIVSQVLPNPPQAVN
  NYKEEPVIVTPPTKQSLVKVLKTPKCALKMDDFECVTPKLEHFGISEYTMCLNEDYTMGL
  KNARNNKSEEAIDTESRLNDNVFATPSPIIQQLEKSDAEYTNSPLVPTFCTPGLKIPSTK
  NSIALVSTNYPLSKTNSSSNDLEVEDRTSLVLNSDTCFENLTDPSSPTISSYENLLRTPT
  PPEVTKIPEDILQLLSKYNSNLATPIAIKAVPPSKRFLKHGQNIRDVSNKEN

• Sequence length: 412

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560