ALDH3B1 (aldehyde dehydrogenase 3 family member B1)

Gene

• Entrez ID: 221
• Gene name: Aldehyde dehydrogenase 3 family member B1
• Gene symbol: ALDH3B1
• Synonyms: ALDH4, ALDH7
• Chromosome: 11
• Chromosome location: 11q13.2
• Summary: This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT451839	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT451838	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT451837	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT451836	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT451835	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT451834	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT451833	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT451832	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT451831	hsa-miR-4468	PAR-CLIP	23592263
MIRT451830	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT451829	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT451828	hsa-miR-107	PAR-CLIP	23592263
MIRT451827	hsa-miR-6077	PAR-CLIP	23592263
MIRT451826	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT451825	hsa-miR-1255a	PAR-CLIP	23592263
MIRT451824	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT451823	hsa-miR-4271	PAR-CLIP	23592263
MIRT451822	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451821	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451820	hsa-miR-2110	PAR-CLIP	23592263
MIRT451839	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT451838	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT451837	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT451836	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT451835	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT451834	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT451833	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT451832	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT451831	hsa-miR-4468	PAR-CLIP	23592263
MIRT451830	hsa-miR-3605-5p	PAR-CLIP	23592263
MIRT451829	hsa-miR-103a-3p	PAR-CLIP	23592263
MIRT451828	hsa-miR-107	PAR-CLIP	23592263
MIRT451827	hsa-miR-6077	PAR-CLIP	23592263
MIRT451826	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT451825	hsa-miR-1255a	PAR-CLIP	23592263
MIRT451824	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT451823	hsa-miR-4271	PAR-CLIP	23592263
MIRT451822	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT451821	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT451820	hsa-miR-2110	PAR-CLIP	23592263
MIRT777292	hsa-miR-1193	CLIP-seq
MIRT777293	hsa-miR-1207-5p	CLIP-seq
MIRT777294	hsa-miR-1238	CLIP-seq
MIRT777295	hsa-miR-182	CLIP-seq
MIRT777296	hsa-miR-1909	CLIP-seq
MIRT777297	hsa-miR-3681	CLIP-seq
MIRT777298	hsa-miR-3691-5p	CLIP-seq
MIRT777299	hsa-miR-4466	CLIP-seq
MIRT777300	hsa-miR-4481	CLIP-seq
MIRT777301	hsa-miR-4691-5p	CLIP-seq
MIRT777302	hsa-miR-4706	CLIP-seq
MIRT777303	hsa-miR-4745-5p	CLIP-seq
MIRT777304	hsa-miR-4749-5p	CLIP-seq
MIRT777305	hsa-miR-4758-5p	CLIP-seq
MIRT777306	hsa-miR-4763-3p	CLIP-seq
MIRT777307	hsa-miR-4793-3p	CLIP-seq
MIRT777308	hsa-miR-486-3p	CLIP-seq
MIRT777309	hsa-miR-500a	CLIP-seq
MIRT777310	hsa-miR-501-5p	CLIP-seq
MIRT777311	hsa-miR-647	CLIP-seq
MIRT777312	hsa-miR-675	CLIP-seq
MIRT777313	hsa-miR-744	CLIP-seq
MIRT777314	hsa-miR-216a	CLIP-seq
MIRT777315	hsa-miR-4722-5p	CLIP-seq
MIRT777316	hsa-miR-548al	CLIP-seq
MIRT1929514	hsa-miR-3149	CLIP-seq
MIRT1929515	hsa-miR-3934	CLIP-seq
MIRT1929516	hsa-miR-4694-3p	CLIP-seq
MIRT1929517	hsa-miR-4724-5p	CLIP-seq
MIRT1929518	hsa-miR-4735-5p	CLIP-seq
MIRT1929519	hsa-miR-4755-3p	CLIP-seq
MIRT1929520	hsa-miR-4775	CLIP-seq
MIRT1929521	hsa-miR-5095	CLIP-seq
MIRT1929522	hsa-miR-552	CLIP-seq
MIRT1929523	hsa-miR-590-3p	CLIP-seq
MIRT2170182	hsa-miR-106a	CLIP-seq
MIRT2170183	hsa-miR-106b	CLIP-seq
MIRT2170184	hsa-miR-1200	CLIP-seq
MIRT2170185	hsa-miR-17	CLIP-seq
MIRT2170186	hsa-miR-1976	CLIP-seq
MIRT2170187	hsa-miR-20a	CLIP-seq
MIRT2170188	hsa-miR-20b	CLIP-seq
MIRT777314	hsa-miR-216a	CLIP-seq
MIRT2170189	hsa-miR-302a	CLIP-seq
MIRT2170190	hsa-miR-302b	CLIP-seq
MIRT2170191	hsa-miR-302c	CLIP-seq
MIRT2170192	hsa-miR-302d	CLIP-seq
MIRT2170193	hsa-miR-302e	CLIP-seq
MIRT1929514	hsa-miR-3149	CLIP-seq
MIRT2170194	hsa-miR-372	CLIP-seq
MIRT2170195	hsa-miR-373	CLIP-seq
MIRT1929515	hsa-miR-3934	CLIP-seq
MIRT2170196	hsa-miR-411	CLIP-seq
MIRT2170197	hsa-miR-4276	CLIP-seq
MIRT2170198	hsa-miR-4279	CLIP-seq
MIRT2170199	hsa-miR-4324	CLIP-seq
MIRT2170200	hsa-miR-4438	CLIP-seq
MIRT2170201	hsa-miR-4537	CLIP-seq
MIRT2170202	hsa-miR-4716-5p	CLIP-seq
MIRT2170203	hsa-miR-4722-3p	CLIP-seq
MIRT2170204	hsa-miR-4731-5p	CLIP-seq
MIRT1929518	hsa-miR-4735-5p	CLIP-seq
MIRT2170205	hsa-miR-4743	CLIP-seq
MIRT1929519	hsa-miR-4755-3p	CLIP-seq
MIRT1929520	hsa-miR-4775	CLIP-seq
MIRT2170206	hsa-miR-4787-3p	CLIP-seq
MIRT2170207	hsa-miR-483-5p	CLIP-seq
MIRT2170208	hsa-miR-498	CLIP-seq
MIRT1929521	hsa-miR-5095	CLIP-seq
MIRT2170209	hsa-miR-512-3p	CLIP-seq
MIRT2170210	hsa-miR-519d	CLIP-seq
MIRT2170211	hsa-miR-520a-3p	CLIP-seq
MIRT2170212	hsa-miR-520b	CLIP-seq
MIRT2170213	hsa-miR-520c-3p	CLIP-seq
MIRT2170214	hsa-miR-520d-3p	CLIP-seq
MIRT2170215	hsa-miR-520e	CLIP-seq
MIRT2170216	hsa-miR-520g	CLIP-seq
MIRT2170217	hsa-miR-520h	CLIP-seq
MIRT2170218	hsa-miR-544b	CLIP-seq
MIRT777316	hsa-miR-548al	CLIP-seq
MIRT1929522	hsa-miR-552	CLIP-seq
MIRT1929523	hsa-miR-590-3p	CLIP-seq
MIRT2170219	hsa-miR-93	CLIP-seq
MIRT2170186	hsa-miR-1976	CLIP-seq
MIRT2170198	hsa-miR-4279	CLIP-seq
MIRT2384068	hsa-miR-4532	CLIP-seq
MIRT2170203	hsa-miR-4722-3p	CLIP-seq
MIRT2170208	hsa-miR-498	CLIP-seq
MIRT2170182	hsa-miR-106a	CLIP-seq
MIRT2170183	hsa-miR-106b	CLIP-seq
MIRT2170184	hsa-miR-1200	CLIP-seq
MIRT2473062	hsa-miR-1234	CLIP-seq
MIRT2473063	hsa-miR-125a-3p	CLIP-seq
MIRT2473064	hsa-miR-150	CLIP-seq
MIRT2170185	hsa-miR-17	CLIP-seq
MIRT2170186	hsa-miR-1976	CLIP-seq
MIRT2170187	hsa-miR-20a	CLIP-seq
MIRT2170188	hsa-miR-20b	CLIP-seq
MIRT2170189	hsa-miR-302a	CLIP-seq
MIRT2170190	hsa-miR-302b	CLIP-seq
MIRT2170191	hsa-miR-302c	CLIP-seq
MIRT2170192	hsa-miR-302d	CLIP-seq
MIRT2170193	hsa-miR-302e	CLIP-seq
MIRT1929514	hsa-miR-3149	CLIP-seq
MIRT2170194	hsa-miR-372	CLIP-seq
MIRT2170195	hsa-miR-373	CLIP-seq
MIRT1929515	hsa-miR-3934	CLIP-seq
MIRT2170196	hsa-miR-411	CLIP-seq
MIRT2170198	hsa-miR-4279	CLIP-seq
MIRT2170199	hsa-miR-4324	CLIP-seq
MIRT2473065	hsa-miR-4454	CLIP-seq
MIRT2384068	hsa-miR-4532	CLIP-seq
MIRT2170203	hsa-miR-4722-3p	CLIP-seq
MIRT1929518	hsa-miR-4735-5p	CLIP-seq
MIRT1929519	hsa-miR-4755-3p	CLIP-seq
MIRT2473066	hsa-miR-4763-5p	CLIP-seq
MIRT1929520	hsa-miR-4775	CLIP-seq
MIRT2170208	hsa-miR-498	CLIP-seq
MIRT2170209	hsa-miR-512-3p	CLIP-seq
MIRT2170210	hsa-miR-519d	CLIP-seq
MIRT2170211	hsa-miR-520a-3p	CLIP-seq
MIRT2170212	hsa-miR-520b	CLIP-seq
MIRT2170213	hsa-miR-520c-3p	CLIP-seq
MIRT2170214	hsa-miR-520d-3p	CLIP-seq
MIRT2170215	hsa-miR-520e	CLIP-seq
MIRT2170216	hsa-miR-520g	CLIP-seq
MIRT2170217	hsa-miR-520h	CLIP-seq
MIRT2170218	hsa-miR-544b	CLIP-seq
MIRT1929523	hsa-miR-590-3p	CLIP-seq
MIRT2473067	hsa-miR-764	CLIP-seq
MIRT2170219	hsa-miR-93	CLIP-seq
MIRT2170182	hsa-miR-106a	CLIP-seq
MIRT2170183	hsa-miR-106b	CLIP-seq
MIRT2170184	hsa-miR-1200	CLIP-seq
MIRT2473062	hsa-miR-1234	CLIP-seq
MIRT2473063	hsa-miR-125a-3p	CLIP-seq
MIRT2473064	hsa-miR-150	CLIP-seq
MIRT2170185	hsa-miR-17	CLIP-seq
MIRT2170186	hsa-miR-1976	CLIP-seq
MIRT2170187	hsa-miR-20a	CLIP-seq
MIRT2170188	hsa-miR-20b	CLIP-seq
MIRT2170189	hsa-miR-302a	CLIP-seq
MIRT2170190	hsa-miR-302b	CLIP-seq
MIRT2170191	hsa-miR-302c	CLIP-seq
MIRT2170192	hsa-miR-302d	CLIP-seq
MIRT2170193	hsa-miR-302e	CLIP-seq
MIRT1929514	hsa-miR-3149	CLIP-seq
MIRT2170194	hsa-miR-372	CLIP-seq
MIRT2170195	hsa-miR-373	CLIP-seq
MIRT1929515	hsa-miR-3934	CLIP-seq
MIRT2170198	hsa-miR-4279	CLIP-seq
MIRT2170199	hsa-miR-4324	CLIP-seq
MIRT2473065	hsa-miR-4454	CLIP-seq
MIRT2170203	hsa-miR-4722-3p	CLIP-seq
MIRT1929518	hsa-miR-4735-5p	CLIP-seq
MIRT1929519	hsa-miR-4755-3p	CLIP-seq
MIRT2473066	hsa-miR-4763-5p	CLIP-seq
MIRT1929520	hsa-miR-4775	CLIP-seq
MIRT2170209	hsa-miR-512-3p	CLIP-seq
MIRT2170210	hsa-miR-519d	CLIP-seq
MIRT2170211	hsa-miR-520a-3p	CLIP-seq
MIRT2170212	hsa-miR-520b	CLIP-seq
MIRT2170213	hsa-miR-520c-3p	CLIP-seq
MIRT2170214	hsa-miR-520d-3p	CLIP-seq
MIRT2170215	hsa-miR-520e	CLIP-seq
MIRT2170216	hsa-miR-520g	CLIP-seq
MIRT2170217	hsa-miR-520h	CLIP-seq
MIRT2170218	hsa-miR-544b	CLIP-seq
MIRT1929523	hsa-miR-590-3p	CLIP-seq
MIRT2473067	hsa-miR-764	CLIP-seq
MIRT2170219	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004028	Function	3-chloroallyl aldehyde dehydrogenase activity	IBA	21873635
GO:0004030	Function	Aldehyde dehydrogenase [NAD(P)+] activity	IDA	20699116
GO:0004030	Function	Aldehyde dehydrogenase [NAD(P)+] activity	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IDA	20699116
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006066	Process	Alcohol metabolic process	TAS	7828891
GO:0006068	Process	Ethanol catabolic process	IEA
GO:0006629	Process	Lipid metabolic process	TAS	7828891
GO:0018477	Function	Benzaldehyde dehydrogenase (NADP+) activity	IEA
GO:0018479	Function	Benzaldehyde dehydrogenase (NAD+) activity	IEA
GO:0030148	Process	Sphingolipid biosynthetic process	TAS
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031982	Component	Vesicle	HDA	19190083
GO:0034599	Process	Cellular response to oxidative stress	IDA	20699116
GO:0035579	Component	Specific granule membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0046185	Process	Aldehyde catabolic process	IDA	20699116
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 600466
• HGNC: 410
• e!Ensembl: ENSG00000006534

Protein

• UniProt ID: P43353
• Protein name: Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.28) (EC 1.2.1.5) (EC 1.2.1.7) (Aldehyde dehydrogenase 7) (Long-chain fatty aldehyde dehydrogenase) (EC 1.2.1.48) (Medium-chain fatty aldehyde dehydrogenase)
• Protein function: Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:23721920). May have a protective role against the cytotoxicity induced by lipid peroxid
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00171	Aldedh	5 → 428	Aldehyde dehydrogenase family	Family

• Sequence:

  MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE
  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL
  TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
  FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
  GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
  GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
  PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
  TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

• Sequence length: 468

Pathways

KEGG:

Glycolysis / Gluconeogenesis
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
beta-Alanine metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways

Reactome:

Sphingolipid de novo biosynthesis
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	16092759, 19159868

Unknown
Disease name	Disease term	dbSNP ID	References
Paranoid schizophrenia	Paranoid Schizophrenia		19159868