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SKA1 (spindle and kinetochore associated complex subunit 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
220134
Gene nameGene Name - the full gene name approved by the HGNC.
Spindle and kinetochore associated complex subunit 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SKA1
SynonymsGene synonyms aliases
C18orf24
ChromosomeChromosome number
18
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.1
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016380 hsa-miR-193b-3p Microarray 20304954
MIRT024386 hsa-miR-215-5p Microarray 19074876
MIRT026316 hsa-miR-192-5p Microarray 19074876
MIRT043769 hsa-miR-328-3p CLASH 23622248
MIRT711382 hsa-miR-6771-3p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000278 Process Mitotic cell cycle IBA 21873635
GO:0000278 Process Mitotic cell cycle IMP 19289083
GO:0000940 Component Condensed chromosome outer kinetochore IBA 21873635
GO:0000940 Component Condensed chromosome outer kinetochore IDA 17093495, 19289083
GO:0005515 Function Protein binding IPI 16189514, 17093495, 19289083, 19360002, 25416956, 26496610, 28514442, 31515488, 32296183
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q96BD8
Protein name SKA complex subunit 1 (Spindle and kinetochore-associated protein 1)
Protein function Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression)
PDB 4AJ5 , 4C9Y , 4CA0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07160 SKA1
16 248
Spindle and kinetochore-associated protein 1
Family
Sequence
Sequence length 255
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 28284560

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