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FABP5 (fatty acid binding protein 5)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2171
Gene nameGene Name - the full gene name approved by the HGNC.
Fatty acid binding protein 5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
FABP5
SynonymsGene synonyms aliases
E-FABP, EFABP, KFABP, PA-FABP, PAFABP
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.13
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fa
Transcription factors
Transcription factor Regulation Reference
KLF2 Repression 20424164
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001972 Function Retinoic acid binding IEA
GO:0005324 Function Long-chain fatty acid transporter activity IMP 21395585
GO:0005504 Function Fatty acid binding IDA 8092987
GO:0005515 Function Protein binding IPI 12839573
GO:0005576 Component Extracellular region TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q01469
Protein name Fatty acid-binding protein 5 (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)
Protein function Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty
PDB 1B56 , 1JJJ , 4AZM , 4AZR , 4LKP , 4LKT , 5HZ5 , 5UR9 , 7FWI , 7FXD , 7FY0 , 7FYD , 7G01 , 7G04 , 7G0B , 7G0E , 7G1Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin
8 134
Lipocalin / cytosolic fatty-acid binding protein family
Domain
Sequence
Sequence length 135
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  PPAR signaling pathway   Triglyceride catabolism
Signaling by Retinoic Acid
Neutrophil degranulation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 25027319, 19554614
Unknown
Disease name Disease term dbSNP ID References
Liver carcinoma Liver carcinoma 21472284
Myocardial ischemia Myocardial Ischemia 16214533

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