F2RL1 (F2R like trypsin receptor 1)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
2150 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
F2R like trypsin receptor 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
F2RL1 |
SynonymsGene synonyms aliases
|
GPR11, PAR2 |
ChromosomeChromosome number
|
5 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q13.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered l |
miRNAmiRNA information provided by mirtarbase database.
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|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001965 |
Function |
G-protein alpha-subunit binding |
ISS |
|
GO:0002286 |
Process |
T cell activation involved in immune response |
ISS |
|
GO:0002690 |
Process |
Positive regulation of leukocyte chemotaxis |
IDA |
17991872 |
GO:0002720 |
Process |
Positive regulation of cytokine production involved in immune response |
IDA |
11441110 |
GO:0003104 |
Process |
Positive regulation of glomerular filtration |
ISS |
|
GO:0004930 |
Function |
G protein-coupled receptor activity |
IBA |
21873635 |
GO:0004930 |
Function |
G protein-coupled receptor activity |
IMP |
18622013, 28445455 |
GO:0004930 |
Function |
G protein-coupled receptor activity |
ISS |
|
GO:0005102 |
Function |
Signaling receptor binding |
TAS |
8615752 |
GO:0005515 |
Function |
Protein binding |
IPI |
10725339, 15708858, 16410250, 16959886, 17693410, 20826780, 21219331, 28298427 |
GO:0005769 |
Component |
Early endosome |
IDA |
22547407 |
GO:0005794 |
Component |
Golgi apparatus |
TAS |
8615752 |
GO:0005886 |
Component |
Plasma membrane |
IDA |
22547407, 28445455 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0005887 |
Component |
Integral component of plasma membrane |
IBA |
21873635 |
GO:0005887 |
Component |
Integral component of plasma membrane |
IDA |
17848177 |
GO:0006954 |
Process |
Inflammatory response |
IEA |
|
GO:0007186 |
Process |
G protein-coupled receptor signaling pathway |
IMP |
28445455 |
GO:0007186 |
Process |
G protein-coupled receptor signaling pathway |
TAS |
|
GO:0007204 |
Process |
Positive regulation of cytosolic calcium ion concentration |
IDA |
10725339 |
GO:0007204 |
Process |
Positive regulation of cytosolic calcium ion concentration |
ISS |
|
GO:0007596 |
Process |
Blood coagulation |
IEA |
|
GO:0010804 |
Process |
Negative regulation of tumor necrosis factor-mediated signaling pathway |
IDA |
19781631 |
GO:0014068 |
Process |
Positive regulation of phosphatidylinositol 3-kinase signaling |
ISS |
|
GO:0015057 |
Function |
Thrombin-activated receptor activity |
IEA |
|
GO:0030193 |
Process |
Regulation of blood coagulation |
IDA |
17848177 |
GO:0030335 |
Process |
Positive regulation of cell migration |
ISS |
|
GO:0030836 |
Process |
Positive regulation of actin filament depolymerization |
IDA |
17500066 |
GO:0031143 |
Component |
Pseudopodium |
ISS |
|
GO:0031274 |
Process |
Positive regulation of pseudopodium assembly |
ISS |
|
GO:0031681 |
Function |
G-protein beta-subunit binding |
ISS |
|
GO:0032602 |
Process |
Chemokine production |
IDA |
19494303, 21501162 |
GO:0032609 |
Process |
Interferon-gamma production |
ISS |
|
GO:0032611 |
Process |
Interleukin-1 beta production |
IDA |
15155775 |
GO:0032613 |
Process |
Interleukin-10 production |
IDA |
18453611 |
GO:0032682 |
Process |
Negative regulation of chemokine production |
IDA |
19865078 |
GO:0032755 |
Process |
Positive regulation of interleukin-6 production |
IDA |
11447194, 15155775 |
GO:0032757 |
Process |
Positive regulation of interleukin-8 production |
IDA |
15155775, 17404307, 18622013, 19865078 |
GO:0032930 |
Process |
Positive regulation of superoxide anion generation |
IDA |
11714832 |
GO:0034137 |
Process |
Positive regulation of toll-like receptor 2 signaling pathway |
IMP |
19865078 |
GO:0034140 |
Process |
Negative regulation of toll-like receptor 3 signaling pathway |
IMP |
19865078 |
GO:0034141 |
Process |
Positive regulation of toll-like receptor 3 signaling pathway |
IMP |
19865078 |
GO:0034145 |
Process |
Positive regulation of toll-like receptor 4 signaling pathway |
IDA |
18622013 |
GO:0035025 |
Process |
Positive regulation of Rho protein signal transduction |
IBA |
21873635 |
GO:0035025 |
Process |
Positive regulation of Rho protein signal transduction |
IMP |
20826780 |
GO:0035025 |
Process |
Positive regulation of Rho protein signal transduction |
ISS |
|
GO:0038023 |
Function |
Signaling receptor activity |
TAS |
8615752 |
GO:0042119 |
Process |
Neutrophil activation |
IDA |
15155775 |
GO:0042311 |
Process |
Vasodilation |
ISS |
|
GO:0043122 |
Process |
Regulation of I-kappaB kinase/NF-kappaB signaling |
IDA |
18453611 |
GO:0043123 |
Process |
Positive regulation of I-kappaB kinase/NF-kappaB signaling |
IDA |
11413129 |
GO:0043311 |
Process |
Positive regulation of eosinophil degranulation |
IDA |
11714832 |
GO:0043547 |
Process |
Positive regulation of GTPase activity |
IMP |
23202369 |
GO:0045087 |
Process |
Innate immune response |
IEA |
|
GO:0045217 |
Process |
Cell-cell junction maintenance |
IMP |
23202369 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
16410250 |
GO:0046328 |
Process |
Regulation of JNK cascade |
IDA |
16410250 |
GO:0046329 |
Process |
Negative regulation of JNK cascade |
IDA |
19781631 |
GO:0046330 |
Process |
Positive regulation of JNK cascade |
IDA |
11413129 |
GO:0050900 |
Process |
Leukocyte migration |
IDA |
15155775 |
GO:0050921 |
Process |
Positive regulation of chemotaxis |
ISS |
|
GO:0050927 |
Process |
Positive regulation of positive chemotaxis |
IDA |
17991872 |
GO:0051482 |
Process |
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
IBA |
21873635 |
GO:0051607 |
Process |
Defense response to virus |
IDA |
18453611, 19494303 |
GO:0060100 |
Process |
Positive regulation of phagocytosis, engulfment |
IDA |
21501162 |
GO:0061028 |
Process |
Establishment of endothelial barrier |
IDA |
20826780 |
GO:0070374 |
Process |
Positive regulation of ERK1 and ERK2 cascade |
IDA |
10725339 |
GO:0070374 |
Process |
Positive regulation of ERK1 and ERK2 cascade |
ISS |
|
GO:0070493 |
Process |
Thrombin-activated receptor signaling pathway |
IEA |
|
GO:0070661 |
Process |
Leukocyte proliferation |
ISS |
|
GO:0070963 |
Process |
Positive regulation of neutrophil mediated killing of gram-negative bacterium |
IDA |
21501162 |
GO:0097029 |
Process |
Mature conventional dendritic cell differentiation |
IDA |
16478888 |
GO:0097029 |
Process |
Mature conventional dendritic cell differentiation |
ISS |
|
GO:1900135 |
Process |
Positive regulation of renin secretion into blood stream |
ISS |
|
GO:2000341 |
Process |
Regulation of chemokine (C-X-C motif) ligand 2 production |
IDA |
21501162 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
P55085 |
Protein name |
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate clea |
Protein function |
Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protei |
PDB |
5NDD
,
5NDZ
,
5NJ6
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00001 |
7tm_1 |
92 → 344 |
7 transmembrane receptor (rhodopsin family) |
Family |
|
Sequence |
|
Sequence length |
397 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Melanoma |
melanoma |
rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050 |
17145863 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Gastroenteritis |
Gastroenteritis |
|
12682265 |
Myocardial ischemia |
Myocardial Ischemia |
|
16214533 |
|
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