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F2RL1 (F2R like trypsin receptor 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2150
Gene nameGene Name - the full gene name approved by the HGNC.
F2R like trypsin receptor 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
F2RL1
SynonymsGene synonyms aliases
GPR11, PAR2
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q13.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered l
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023577 hsa-miR-1-3p Microarray 18668037
MIRT724017 hsa-miR-483-3p HITS-CLIP 19536157
MIRT724016 hsa-miR-6747-3p HITS-CLIP 19536157
MIRT724015 hsa-miR-1304-3p HITS-CLIP 19536157
MIRT629097 hsa-miR-367-5p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001965 Function G-protein alpha-subunit binding ISS
GO:0002286 Process T cell activation involved in immune response ISS
GO:0002690 Process Positive regulation of leukocyte chemotaxis IDA 17991872
GO:0002720 Process Positive regulation of cytokine production involved in immune response IDA 11441110
GO:0003104 Process Positive regulation of glomerular filtration ISS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P55085
Protein name Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate clea
Protein function Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protei
PDB 5NDD , 5NDZ , 5NJ6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1
92 344
7 transmembrane receptor (rhodopsin family)
Family
Sequence
Sequence length 397
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
African trypanosomiasis
  Peptide ligand-binding receptors
G alpha (q) signalling events
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050 17145863
Unknown
Disease name Disease term dbSNP ID References
Gastroenteritis Gastroenteritis 12682265
Myocardial ischemia Myocardial Ischemia 16214533

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