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F2R (coagulation factor II thrombin receptor)

Gene

2149

Coagulation factor II thrombin receptor

F2R

CF2R, HTR, PAR-1, PAR1, TR

5q13.3

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results i

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miRTarBase ID	miRNA	Experiments	Reference
MIRT052570	hsa-let-7a-5p	CLASH	23622248
MIRT037083	hsa-miR-877-3p	CLASH	23622248
MIRT706041	hsa-miR-186-3p	HITS-CLIP	22927820
MIRT706040	hsa-miR-150-5p	HITS-CLIP	22927820
MIRT706039	hsa-miR-3653-5p	HITS-CLIP	22927820
MIRT706038	hsa-miR-1976	HITS-CLIP	22927820
MIRT706037	hsa-miR-6790-3p	HITS-CLIP	22927820
MIRT706036	hsa-miR-6821-3p	HITS-CLIP	22927820
MIRT706035	hsa-miR-6778-3p	HITS-CLIP	22927820
MIRT706034	hsa-miR-1193	HITS-CLIP	22927820
MIRT706033	hsa-miR-378a-5p	HITS-CLIP	22927820
MIRT706032	hsa-miR-640	HITS-CLIP	22927820
MIRT706031	hsa-miR-6843-3p	HITS-CLIP	22927820
MIRT706030	hsa-miR-6848-3p	HITS-CLIP	22927820
MIRT571222	hsa-miR-3609	PAR-CLIP	20371350
MIRT571221	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT216663	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT216664	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT216660	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT216661	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT216667	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT216671	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT216670	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT216662	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT571220	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT216674	hsa-miR-33b-3p	PAR-CLIP	20371350
MIRT216668	hsa-miR-515-3p	PAR-CLIP	20371350
MIRT216669	hsa-miR-519e-3p	PAR-CLIP	20371350
MIRT216681	hsa-miR-3659	PAR-CLIP	20371350
MIRT216686	hsa-miR-4706	PAR-CLIP	20371350
MIRT216687	hsa-miR-4749-5p	PAR-CLIP	20371350
MIRT571219	hsa-miR-744-5p	PAR-CLIP	20371350
MIRT216678	hsa-miR-3153	PAR-CLIP	20371350
MIRT216690	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT216692	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT216682	hsa-miR-4466	PAR-CLIP	20371350
MIRT216676	hsa-miR-675-5p	PAR-CLIP	20371350
MIRT706041	hsa-miR-186-3p	HITS-CLIP	22927820
MIRT706040	hsa-miR-150-5p	HITS-CLIP	22927820
MIRT706039	hsa-miR-3653-5p	HITS-CLIP	22927820
MIRT706038	hsa-miR-1976	HITS-CLIP	22927820
MIRT706037	hsa-miR-6790-3p	HITS-CLIP	22927820
MIRT706036	hsa-miR-6821-3p	HITS-CLIP	22927820
MIRT706035	hsa-miR-6778-3p	HITS-CLIP	22927820
MIRT706034	hsa-miR-1193	HITS-CLIP	22927820
MIRT706033	hsa-miR-378a-5p	HITS-CLIP	22927820
MIRT706032	hsa-miR-640	HITS-CLIP	22927820
MIRT706031	hsa-miR-6843-3p	HITS-CLIP	22927820
MIRT706030	hsa-miR-6848-3p	HITS-CLIP	22927820
MIRT571222	hsa-miR-3609	PAR-CLIP	20371350
MIRT571221	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT216663	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT216664	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT216660	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT216661	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT216667	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT216671	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT216670	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT216662	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT571220	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT216674	hsa-miR-33b-3p	PAR-CLIP	20371350
MIRT216668	hsa-miR-515-3p	PAR-CLIP	20371350
MIRT216669	hsa-miR-519e-3p	PAR-CLIP	20371350
MIRT216681	hsa-miR-3659	PAR-CLIP	20371350
MIRT216686	hsa-miR-4706	PAR-CLIP	20371350
MIRT216687	hsa-miR-4749-5p	PAR-CLIP	20371350
MIRT571219	hsa-miR-744-5p	PAR-CLIP	20371350
MIRT216678	hsa-miR-3153	PAR-CLIP	20371350
MIRT216690	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT216692	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT216682	hsa-miR-4466	PAR-CLIP	20371350
MIRT216676	hsa-miR-675-5p	PAR-CLIP	20371350
MIRT974316	hsa-miR-106a	CLIP-seq
MIRT974317	hsa-miR-106b	CLIP-seq
MIRT974318	hsa-miR-128	CLIP-seq
MIRT974319	hsa-miR-150	CLIP-seq
MIRT974320	hsa-miR-17	CLIP-seq
MIRT974321	hsa-miR-1825	CLIP-seq
MIRT974322	hsa-miR-20a	CLIP-seq
MIRT974323	hsa-miR-20b	CLIP-seq
MIRT974324	hsa-miR-2115	CLIP-seq
MIRT974325	hsa-miR-2392	CLIP-seq
MIRT974326	hsa-miR-302a	CLIP-seq
MIRT974327	hsa-miR-302b	CLIP-seq
MIRT974328	hsa-miR-302c	CLIP-seq
MIRT974329	hsa-miR-302d	CLIP-seq
MIRT974330	hsa-miR-302e	CLIP-seq
MIRT974331	hsa-miR-3074-3p	CLIP-seq
MIRT974332	hsa-miR-3135b	CLIP-seq
MIRT974333	hsa-miR-3152-3p	CLIP-seq
MIRT974334	hsa-miR-3176	CLIP-seq
MIRT974335	hsa-miR-3182	CLIP-seq
MIRT974336	hsa-miR-361-5p	CLIP-seq
MIRT974337	hsa-miR-3652	CLIP-seq
MIRT974338	hsa-miR-372	CLIP-seq
MIRT974339	hsa-miR-373	CLIP-seq
MIRT974340	hsa-miR-3922-3p	CLIP-seq
MIRT974341	hsa-miR-3942-3p	CLIP-seq
MIRT974342	hsa-miR-4263	CLIP-seq
MIRT974343	hsa-miR-4423-5p	CLIP-seq
MIRT974344	hsa-miR-4430	CLIP-seq
MIRT974345	hsa-miR-4438	CLIP-seq
MIRT974346	hsa-miR-4506	CLIP-seq
MIRT974347	hsa-miR-4634	CLIP-seq
MIRT974348	hsa-miR-4652-3p	CLIP-seq
MIRT974349	hsa-miR-4659a-3p	CLIP-seq
MIRT974350	hsa-miR-4659b-3p	CLIP-seq
MIRT974351	hsa-miR-4662a-5p	CLIP-seq
MIRT974352	hsa-miR-4676-5p	CLIP-seq
MIRT974353	hsa-miR-4731-5p	CLIP-seq
MIRT974354	hsa-miR-483-5p	CLIP-seq
MIRT974355	hsa-miR-5095	CLIP-seq
MIRT974356	hsa-miR-5096	CLIP-seq
MIRT974357	hsa-miR-512-3p	CLIP-seq
MIRT974358	hsa-miR-516a-3p	CLIP-seq
MIRT974359	hsa-miR-519d	CLIP-seq
MIRT974360	hsa-miR-520a-3p	CLIP-seq
MIRT974361	hsa-miR-520b	CLIP-seq
MIRT974362	hsa-miR-520c-3p	CLIP-seq
MIRT974363	hsa-miR-520d-3p	CLIP-seq
MIRT974364	hsa-miR-520e	CLIP-seq
MIRT974365	hsa-miR-520g	CLIP-seq
MIRT974366	hsa-miR-520h	CLIP-seq
MIRT974367	hsa-miR-548aa	CLIP-seq
MIRT974368	hsa-miR-575	CLIP-seq
MIRT974369	hsa-miR-576-5p	CLIP-seq
MIRT974370	hsa-miR-587	CLIP-seq
MIRT974371	hsa-miR-621	CLIP-seq
MIRT974372	hsa-miR-93	CLIP-seq
MIRT974316	hsa-miR-106a	CLIP-seq
MIRT974317	hsa-miR-106b	CLIP-seq
MIRT1556325	hsa-miR-1284	CLIP-seq
MIRT974320	hsa-miR-17	CLIP-seq
MIRT974322	hsa-miR-20a	CLIP-seq
MIRT974323	hsa-miR-20b	CLIP-seq
MIRT1556326	hsa-miR-217	CLIP-seq
MIRT1556327	hsa-miR-4418	CLIP-seq
MIRT1556328	hsa-miR-4793-3p	CLIP-seq
MIRT1556329	hsa-miR-509-3-5p	CLIP-seq
MIRT1556330	hsa-miR-509-5p	CLIP-seq
MIRT974359	hsa-miR-519d	CLIP-seq
MIRT1556331	hsa-miR-519e	CLIP-seq
MIRT1556332	hsa-miR-548ah	CLIP-seq
MIRT974372	hsa-miR-93	CLIP-seq
MIRT974325	hsa-miR-2392	CLIP-seq
MIRT974333	hsa-miR-3152-3p	CLIP-seq
MIRT1922028	hsa-miR-33a	CLIP-seq
MIRT1922029	hsa-miR-33b	CLIP-seq
MIRT1922030	hsa-miR-411	CLIP-seq
MIRT974351	hsa-miR-4662a-5p	CLIP-seq
MIRT974352	hsa-miR-4676-5p	CLIP-seq
MIRT974354	hsa-miR-483-5p	CLIP-seq
MIRT974356	hsa-miR-5096	CLIP-seq
MIRT974368	hsa-miR-575	CLIP-seq
MIRT974318	hsa-miR-128	CLIP-seq
MIRT1988677	hsa-miR-129-5p	CLIP-seq
MIRT1988678	hsa-miR-154	CLIP-seq
MIRT1988679	hsa-miR-23a	CLIP-seq
MIRT1988680	hsa-miR-23b	CLIP-seq
MIRT1988681	hsa-miR-23c	CLIP-seq
MIRT974332	hsa-miR-3135b	CLIP-seq
MIRT1988682	hsa-miR-3199	CLIP-seq
MIRT1922028	hsa-miR-33a	CLIP-seq
MIRT1922029	hsa-miR-33b	CLIP-seq
MIRT974337	hsa-miR-3652	CLIP-seq
MIRT1922030	hsa-miR-411	CLIP-seq
MIRT974343	hsa-miR-4423-5p	CLIP-seq
MIRT974344	hsa-miR-4430	CLIP-seq
MIRT1988683	hsa-miR-450b-5p	CLIP-seq
MIRT974347	hsa-miR-4634	CLIP-seq
MIRT1988684	hsa-miR-4715-3p	CLIP-seq
MIRT1988685	hsa-miR-4722-3p	CLIP-seq
MIRT1988686	hsa-miR-4729	CLIP-seq
MIRT1988687	hsa-miR-4735-5p	CLIP-seq
MIRT1988688	hsa-miR-4740-3p	CLIP-seq
MIRT1988689	hsa-miR-4763-5p	CLIP-seq
MIRT1988690	hsa-miR-4775	CLIP-seq
MIRT974354	hsa-miR-483-5p	CLIP-seq
MIRT1988691	hsa-miR-507	CLIP-seq
MIRT974356	hsa-miR-5096	CLIP-seq
MIRT1988692	hsa-miR-550a	CLIP-seq
MIRT1988693	hsa-miR-552	CLIP-seq
MIRT1988694	hsa-miR-557	CLIP-seq
MIRT1988695	hsa-miR-590-3p	CLIP-seq
MIRT1988696	hsa-miR-764	CLIP-seq
MIRT2223102	hsa-miR-1267	CLIP-seq
MIRT974318	hsa-miR-128	CLIP-seq
MIRT2223103	hsa-miR-1281	CLIP-seq
MIRT1988677	hsa-miR-129-5p	CLIP-seq
MIRT2223104	hsa-miR-1307	CLIP-seq
MIRT2223105	hsa-miR-1343	CLIP-seq
MIRT974325	hsa-miR-2392	CLIP-seq
MIRT974332	hsa-miR-3135b	CLIP-seq
MIRT1988682	hsa-miR-3199	CLIP-seq
MIRT2223106	hsa-miR-338-5p	CLIP-seq
MIRT1922028	hsa-miR-33a	CLIP-seq
MIRT1922029	hsa-miR-33b	CLIP-seq
MIRT974337	hsa-miR-3652	CLIP-seq
MIRT2223107	hsa-miR-4284	CLIP-seq
MIRT974343	hsa-miR-4423-5p	CLIP-seq
MIRT974344	hsa-miR-4430	CLIP-seq
MIRT2223108	hsa-miR-4534	CLIP-seq
MIRT974347	hsa-miR-4634	CLIP-seq
MIRT2223109	hsa-miR-4638-5p	CLIP-seq
MIRT1988685	hsa-miR-4722-3p	CLIP-seq
MIRT1988687	hsa-miR-4735-5p	CLIP-seq
MIRT1988688	hsa-miR-4740-3p	CLIP-seq
MIRT1988690	hsa-miR-4775	CLIP-seq
MIRT2223110	hsa-miR-4803	CLIP-seq
MIRT2223111	hsa-miR-548ac	CLIP-seq
MIRT2223112	hsa-miR-548ae	CLIP-seq
MIRT2223113	hsa-miR-548aj	CLIP-seq
MIRT2223114	hsa-miR-548am	CLIP-seq
MIRT2223115	hsa-miR-548d-3p	CLIP-seq
MIRT2223116	hsa-miR-548x	CLIP-seq
MIRT2223117	hsa-miR-548z	CLIP-seq
MIRT1988693	hsa-miR-552	CLIP-seq
MIRT2223118	hsa-miR-582-5p	CLIP-seq
MIRT1988695	hsa-miR-590-3p	CLIP-seq
MIRT2223119	hsa-miR-624	CLIP-seq
MIRT974316	hsa-miR-106a	CLIP-seq
MIRT974317	hsa-miR-106b	CLIP-seq
MIRT2526986	hsa-miR-1245b-5p	CLIP-seq
MIRT2526987	hsa-miR-1248	CLIP-seq
MIRT2526988	hsa-miR-1254	CLIP-seq
MIRT2526989	hsa-miR-1266	CLIP-seq
MIRT974318	hsa-miR-128	CLIP-seq
MIRT2526990	hsa-miR-1289	CLIP-seq
MIRT2526991	hsa-miR-1291	CLIP-seq
MIRT1988677	hsa-miR-129-5p	CLIP-seq
MIRT2526992	hsa-miR-1301	CLIP-seq
MIRT2526993	hsa-miR-147	CLIP-seq
MIRT974319	hsa-miR-150	CLIP-seq
MIRT974320	hsa-miR-17	CLIP-seq
MIRT974322	hsa-miR-20a	CLIP-seq
MIRT974323	hsa-miR-20b	CLIP-seq
MIRT2526994	hsa-miR-28-3p	CLIP-seq
MIRT974326	hsa-miR-302a	CLIP-seq
MIRT974327	hsa-miR-302b	CLIP-seq
MIRT974328	hsa-miR-302c	CLIP-seq
MIRT974329	hsa-miR-302d	CLIP-seq
MIRT974330	hsa-miR-302e	CLIP-seq
MIRT2526995	hsa-miR-3116	CLIP-seq
MIRT2526996	hsa-miR-3130-5p	CLIP-seq
MIRT974332	hsa-miR-3135b	CLIP-seq
MIRT2526997	hsa-miR-3140-3p	CLIP-seq
MIRT2526998	hsa-miR-3142	CLIP-seq
MIRT2526999	hsa-miR-3180	CLIP-seq
MIRT2527000	hsa-miR-3180-3p	CLIP-seq
MIRT2527001	hsa-miR-3196	CLIP-seq
MIRT2527002	hsa-miR-3198	CLIP-seq
MIRT2527003	hsa-miR-328	CLIP-seq
MIRT1922028	hsa-miR-33a	CLIP-seq
MIRT1922029	hsa-miR-33b	CLIP-seq
MIRT2527004	hsa-miR-346	CLIP-seq
MIRT2527005	hsa-miR-3622b-5p	CLIP-seq
MIRT974337	hsa-miR-3652	CLIP-seq
MIRT2527006	hsa-miR-3664-3p	CLIP-seq
MIRT2527007	hsa-miR-3664-5p	CLIP-seq
MIRT2527008	hsa-miR-3681	CLIP-seq
MIRT2527009	hsa-miR-3691-5p	CLIP-seq
MIRT974338	hsa-miR-372	CLIP-seq
MIRT974339	hsa-miR-373	CLIP-seq
MIRT974341	hsa-miR-3942-3p	CLIP-seq
MIRT2527010	hsa-miR-3945	CLIP-seq
MIRT1922030	hsa-miR-411	CLIP-seq
MIRT2527011	hsa-miR-4253	CLIP-seq
MIRT2527012	hsa-miR-4254	CLIP-seq
MIRT2527013	hsa-miR-4266	CLIP-seq
MIRT2527014	hsa-miR-4288	CLIP-seq
MIRT2527015	hsa-miR-4294	CLIP-seq
MIRT2527016	hsa-miR-4297	CLIP-seq
MIRT2527017	hsa-miR-4309	CLIP-seq
MIRT2527018	hsa-miR-4312	CLIP-seq
MIRT974343	hsa-miR-4423-5p	CLIP-seq
MIRT974344	hsa-miR-4430	CLIP-seq
MIRT2527019	hsa-miR-4482	CLIP-seq
MIRT2527020	hsa-miR-4488	CLIP-seq
MIRT1988683	hsa-miR-450b-5p	CLIP-seq
MIRT2527021	hsa-miR-4518	CLIP-seq
MIRT974347	hsa-miR-4634	CLIP-seq
MIRT2527022	hsa-miR-4643	CLIP-seq
MIRT2527023	hsa-miR-4650-5p	CLIP-seq
MIRT2527024	hsa-miR-4660	CLIP-seq
MIRT2527025	hsa-miR-4691-5p	CLIP-seq
MIRT2527026	hsa-miR-4695-5p	CLIP-seq
MIRT2527027	hsa-miR-4697-5p	CLIP-seq
MIRT2527028	hsa-miR-4711-3p	CLIP-seq
MIRT2527029	hsa-miR-4714-5p	CLIP-seq
MIRT1988684	hsa-miR-4715-3p	CLIP-seq
MIRT2527030	hsa-miR-4720-5p	CLIP-seq
MIRT974353	hsa-miR-4731-5p	CLIP-seq
MIRT1988687	hsa-miR-4735-5p	CLIP-seq
MIRT2527031	hsa-miR-4766-5p	CLIP-seq
MIRT1988690	hsa-miR-4775	CLIP-seq
MIRT2527032	hsa-miR-4779	CLIP-seq
MIRT2527033	hsa-miR-4787-5p	CLIP-seq
MIRT2527034	hsa-miR-4799-3p	CLIP-seq
MIRT974354	hsa-miR-483-5p	CLIP-seq
MIRT2527035	hsa-miR-494	CLIP-seq
MIRT2527036	hsa-miR-5047	CLIP-seq
MIRT1988691	hsa-miR-507	CLIP-seq
MIRT974356	hsa-miR-5096	CLIP-seq
MIRT974357	hsa-miR-512-3p	CLIP-seq
MIRT974359	hsa-miR-519d	CLIP-seq
MIRT974360	hsa-miR-520a-3p	CLIP-seq
MIRT974361	hsa-miR-520b	CLIP-seq
MIRT974362	hsa-miR-520c-3p	CLIP-seq
MIRT974363	hsa-miR-520d-3p	CLIP-seq
MIRT974364	hsa-miR-520e	CLIP-seq
MIRT974365	hsa-miR-520g	CLIP-seq
MIRT974366	hsa-miR-520h	CLIP-seq
MIRT2527037	hsa-miR-532-5p	CLIP-seq
MIRT1988694	hsa-miR-557	CLIP-seq
MIRT2527038	hsa-miR-576-3p	CLIP-seq
MIRT1988695	hsa-miR-590-3p	CLIP-seq
MIRT2527039	hsa-miR-599	CLIP-seq
MIRT2527040	hsa-miR-606	CLIP-seq
MIRT2527041	hsa-miR-632	CLIP-seq
MIRT2527042	hsa-miR-642b	CLIP-seq
MIRT2527043	hsa-miR-661	CLIP-seq
MIRT2527044	hsa-miR-873	CLIP-seq
MIRT974372	hsa-miR-93	CLIP-seq
MIRT2526988	hsa-miR-1254	CLIP-seq
MIRT2526990	hsa-miR-1289	CLIP-seq
MIRT1988677	hsa-miR-129-5p	CLIP-seq
MIRT2526994	hsa-miR-28-3p	CLIP-seq
MIRT2526995	hsa-miR-3116	CLIP-seq
MIRT2526996	hsa-miR-3130-5p	CLIP-seq
MIRT2527002	hsa-miR-3198	CLIP-seq
MIRT1922028	hsa-miR-33a	CLIP-seq
MIRT1922029	hsa-miR-33b	CLIP-seq
MIRT2527004	hsa-miR-346	CLIP-seq
MIRT2527008	hsa-miR-3681	CLIP-seq
MIRT2527009	hsa-miR-3691-5p	CLIP-seq
MIRT974341	hsa-miR-3942-3p	CLIP-seq
MIRT1922030	hsa-miR-411	CLIP-seq
MIRT2527012	hsa-miR-4254	CLIP-seq
MIRT2527014	hsa-miR-4288	CLIP-seq
MIRT2527015	hsa-miR-4294	CLIP-seq
MIRT2527017	hsa-miR-4309	CLIP-seq
MIRT2527019	hsa-miR-4482	CLIP-seq
MIRT1988683	hsa-miR-450b-5p	CLIP-seq
MIRT2527025	hsa-miR-4691-5p	CLIP-seq
MIRT2527028	hsa-miR-4711-3p	CLIP-seq
MIRT1988684	hsa-miR-4715-3p	CLIP-seq
MIRT1988687	hsa-miR-4735-5p	CLIP-seq
MIRT1988690	hsa-miR-4775	CLIP-seq
MIRT1988691	hsa-miR-507	CLIP-seq
MIRT1988694	hsa-miR-557	CLIP-seq
MIRT2527038	hsa-miR-576-3p	CLIP-seq
MIRT1988695	hsa-miR-590-3p	CLIP-seq
MIRT2527040	hsa-miR-606	CLIP-seq
MIRT2527041	hsa-miR-632	CLIP-seq
MIRT2527043	hsa-miR-661	CLIP-seq

Transcription factors

Show/Hide all(6)

Transcription factor	Regulation	Reference
SP1	Unknown	9494121
SP3	Unknown	9494121
STAT3	Activation	23504318
TFAP2A	Unknown	20805990
TWIST1	Repression	19051271
TWIST2	Repression	19051271

Show/Hide all(73)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000186	Process	Activation of MAPKK activity	ISS
GO:0001965	Function	G-protein alpha-subunit binding	ISS
GO:0002248	Process	Connective tissue replacement involved in inflammatory response wound healing	IDA	9639571
GO:0003105	Process	Negative regulation of glomerular filtration	ISS
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004930	Function	G protein-coupled receptor activity	ISS
GO:0004930	Function	G protein-coupled receptor activity	TAS	17848177
GO:0005102	Function	Signaling receptor binding	IPI	1672265
GO:0005515	Function	Protein binding	IPI	17299037, 17848177, 20164183, 20826780, 22547407, 24732013
GO:0005576	Component	Extracellular region	TAS
GO:0005769	Component	Early endosome	IDA	22547407, 24732013
GO:0005770	Component	Late endosome	IDA	24732013
GO:0005794	Component	Golgi apparatus	TAS	7961693
GO:0005886	Component	Plasma membrane	IDA	9038223, 22547407
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005901	Component	Caveola	IDA	17848177
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	10692450
GO:0006954	Process	Inflammatory response	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	20164183
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	ISS
GO:0007205	Process	Protein kinase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007529	Process	Establishment of synaptic specificity at neuromuscular junction	ISS
GO:0007596	Process	Blood coagulation	TAS
GO:0008284	Process	Positive regulation of cell population proliferation	ISS
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	10692450
GO:0009611	Process	Response to wounding	IDA	9639571
GO:0009653	Process	Anatomical structure morphogenesis	TAS	9701242
GO:0009986	Component	Cell surface	IDA	24732013
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	ISS
GO:0015057	Function	Thrombin-activated receptor activity	IBA	21873635
GO:0015057	Function	Thrombin-activated receptor activity	IDA	1672265, 10692450
GO:0030168	Process	Platelet activation	IDA	9038223
GO:0030168	Process	Platelet activation	TAS
GO:0030193	Process	Regulation of blood coagulation	IDA	17848177
GO:0030194	Process	Positive regulation of blood coagulation	IBA	21873635
GO:0030194	Process	Positive regulation of blood coagulation	IDA	9038223
GO:0030335	Process	Positive regulation of cell migration	IMP	9701242
GO:0031094	Component	Platelet dense tubular network	IDA	9038223
GO:0031594	Component	Neuromuscular junction	ISS
GO:0031681	Function	G-protein beta-subunit binding	ISS
GO:0032496	Process	Response to lipopolysaccharide	ISS
GO:0032651	Process	Regulation of interleukin-1 beta production	ISS
GO:0032755	Process	Positive regulation of interleukin-6 production	IDA	11447194
GO:0032757	Process	Positive regulation of interleukin-8 production	IDA	17404307
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IDA	9639571
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IBA	21873635
GO:0035025	Process	Positive regulation of Rho protein signal transduction	ISS
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP	12761501
GO:0043280	Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	10692450
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	17848177
GO:0043524	Process	Negative regulation of neuron apoptotic process	ISS
GO:0043547	Process	Positive regulation of GTPase activity	IMP	23202369
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0045217	Process	Cell-cell junction maintenance	IMP	23202369
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	17848177
GO:0045907	Process	Positive regulation of vasoconstriction	ISS
GO:0045987	Process	Positive regulation of smooth muscle contraction	ISS
GO:0046427	Process	Positive regulation of receptor signaling pathway via JAK-STAT	NAS	10692450
GO:0048873	Process	Homeostasis of number of cells within a tissue	ISS
GO:0051209	Process	Release of sequestered calcium ion into cytosol	ISS
GO:0051281	Process	Positive regulation of release of sequestered calcium ion into cytosol	IDA	1672265
GO:0051482	Process	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	21873635
GO:0051482	Process	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	ISS
GO:0051928	Process	Positive regulation of calcium ion transport	ISS
GO:0051930	Process	Regulation of sensory perception of pain	ISS
GO:0060155	Process	Platelet dense granule organization	IC	1672265
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0070493	Process	Thrombin-activated receptor signaling pathway	IEA
GO:0099553	Process	Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IEA
GO:1900134	Process	Negative regulation of renin secretion into blood stream	ISS

MIM	HGNC	e!Ensembl
187930	3537	ENSG00000181104

Protein

UniProt ID

P25116

Protein name

Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)

Protein function

High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, ac

PDB

1NRN , 1NRO , 1NRP , 1NRQ , 1NRR , 3BEF , 3HKI , 3HKJ , 3LU9 , 3VW7 , 8XOR , 8XOS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	119 → 371	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT

Sequence length

425

Interactions

View interactions

	KEGG		Reactome
	Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Complement and coagulation cascades Platelet activation Regulation of actin cytoskeleton Pathogenic Escherichia coli infection Pathways in cancer		Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs)

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923

Show/Hide Unknown Diseases (4)

Unknown
Disease name	Disease term	dbSNP ID	References
Fatty liver	Fatty Liver, Steatohepatitis		22841818, 21907177, 20008134, 22841818, 20008134, 21907177
Liver cirrhosis	Liver Cirrhosis		21037076
Liver fibrosis	Fibrosis, Liver		21037076
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16367923

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