F2 (coagulation factor II, thrombin)

Gene

• Entrez ID: 2147
• Gene name: Coagulation factor II, thrombin
• Gene symbol: F2
• Synonyms: PT, RPRGL2, THPH1
• Chromosome: 11
• Chromosome location: 11p11.2
• Summary: This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1799963	G>A	Pathogenic, risk-factor	Downstream transcript variant, genic downstream transcript variant, 3 prime UTR variant
rs62623459	G>A	Pathogenic, uncertain-significance	Coding sequence variant, missense variant, non coding transcript variant
rs121918477	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918478	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918479	C>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918480	G>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918481	T>C	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918482	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918483	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918484	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918485	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs121918486	C>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs387906522	->T	Pathogenic	Stop gained, coding sequence variant, non coding transcript variant
rs387907201	G>A,T	Pathogenic, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, non coding transcript variant
rs754231232	G>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs767702854	AAG>-	Likely-pathogenic	Coding sequence variant, non coding transcript variant, inframe deletion
rs776618390	AT>-	Uncertain-significance, likely-pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1227147475	A>G	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1592422740	T>C	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001484	hsa-miR-16-5p	pSILAC	18668040
MIRT021414	hsa-miR-9-5p	Microarray	17612493
MIRT001360	hsa-miR-1-3p	Proteomics	18668040
MIRT001484	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT001622	hsa-let-7b-5p	Proteomics	18668040
MIRT551436	hsa-miR-1306-5p	HITS-CLIP	21572407
MIRT517922	hsa-miR-1224-3p	HITS-CLIP	21572407
MIRT517921	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT551435	hsa-miR-660-3p	HITS-CLIP	21572407
MIRT551434	hsa-miR-939-3p	HITS-CLIP	21572407
MIRT551433	hsa-miR-6852-5p	HITS-CLIP	21572407
MIRT551432	hsa-miR-6742-3p	HITS-CLIP	21572407
MIRT517920	hsa-miR-532-3p	HITS-CLIP	21572407
MIRT551431	hsa-miR-378g	HITS-CLIP	21572407
MIRT517919	hsa-miR-6778-3p	HITS-CLIP	21572407
MIRT517918	hsa-miR-423-3p	HITS-CLIP	21572407
MIRT517917	hsa-miR-4437	HITS-CLIP	21572407
MIRT517916	hsa-miR-1260a	HITS-CLIP	21572407
MIRT517915	hsa-miR-1260b	HITS-CLIP	21572407
MIRT517914	hsa-miR-6749-3p	HITS-CLIP	21572407
MIRT551430	hsa-miR-1343-3p	HITS-CLIP	21572407
MIRT551429	hsa-miR-6783-3p	HITS-CLIP	21572407
MIRT517913	hsa-miR-4674	HITS-CLIP	21572407
MIRT673592	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT672199	hsa-miR-3655	HITS-CLIP	23824327
MIRT673591	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT672198	hsa-miR-3135b	HITS-CLIP	23824327
MIRT672197	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT672196	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT672195	hsa-miR-3652	HITS-CLIP	23824327
MIRT672194	hsa-miR-4430	HITS-CLIP	23824327
MIRT673590	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT672192	hsa-miR-5698	HITS-CLIP	23824327
MIRT673593	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT673592	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT672199	hsa-miR-3655	HITS-CLIP	23824327
MIRT673591	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT672198	hsa-miR-3135b	HITS-CLIP	23824327
MIRT672197	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT672196	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT672195	hsa-miR-3652	HITS-CLIP	23824327
MIRT672194	hsa-miR-4430	HITS-CLIP	23824327
MIRT673590	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT672192	hsa-miR-5698	HITS-CLIP	23824327
MIRT672199	hsa-miR-3655	HITS-CLIP	23824327
MIRT672198	hsa-miR-3135b	HITS-CLIP	23824327
MIRT672197	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT672196	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT672195	hsa-miR-3652	HITS-CLIP	23824327
MIRT672194	hsa-miR-4430	HITS-CLIP	23824327
MIRT672193	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT672192	hsa-miR-5698	HITS-CLIP	23824327
MIRT647952	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT647950	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT647951	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT633778	hsa-miR-662	HITS-CLIP	23824327
MIRT633777	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT517920	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT633776	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633775	hsa-miR-1976	HITS-CLIP	23824327
MIRT517919	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633774	hsa-miR-1206	HITS-CLIP	23824327
MIRT633773	hsa-miR-4279	HITS-CLIP	23824327
MIRT633772	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT551436	hsa-miR-1306-5p	PAR-CLIP	21572407
MIRT517922	hsa-miR-1224-3p	PAR-CLIP	21572407
MIRT517921	hsa-miR-4740-3p	PAR-CLIP	21572407
MIRT551435	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT551434	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT551433	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT551432	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT517920	hsa-miR-532-3p	PAR-CLIP	21572407
MIRT551431	hsa-miR-378g	PAR-CLIP	21572407
MIRT517919	hsa-miR-6778-3p	PAR-CLIP	21572407
MIRT517917	hsa-miR-4437	PAR-CLIP	21572407
MIRT517916	hsa-miR-1260a	PAR-CLIP	21572407
MIRT517915	hsa-miR-1260b	PAR-CLIP	21572407
MIRT517914	hsa-miR-6749-3p	PAR-CLIP	21572407
MIRT551430	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT551429	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT517913	hsa-miR-4674	PAR-CLIP	21572407
MIRT517922	hsa-miR-1224-3p	PAR-CLIP	23446348
MIRT517921	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT517920	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT517919	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT517918	hsa-miR-423-3p	PAR-CLIP	23446348
MIRT517917	hsa-miR-4437	PAR-CLIP	23446348
MIRT517916	hsa-miR-1260a	PAR-CLIP	23446348
MIRT517915	hsa-miR-1260b	PAR-CLIP	23446348
MIRT517914	hsa-miR-6749-3p	PAR-CLIP	23446348
MIRT517913	hsa-miR-4674	PAR-CLIP	23446348
MIRT517922	hsa-miR-1224-3p	PAR-CLIP	27292025
MIRT517922	hsa-miR-1224-3p	PAR-CLIP	27292025
MIRT517916	hsa-miR-1260a	PAR-CLIP	27292025
MIRT517916	hsa-miR-1260a	PAR-CLIP	27292025
MIRT517915	hsa-miR-1260b	PAR-CLIP	27292025
MIRT517915	hsa-miR-1260b	PAR-CLIP	27292025
MIRT551436	hsa-miR-1306-5p	PAR-CLIP	27292025
MIRT551430	hsa-miR-1343-3p	PAR-CLIP	27292025
MIRT647952	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT647950	hsa-miR-3614-5p	PAR-CLIP	27292025
MIRT551431	hsa-miR-378g	PAR-CLIP	27292025
MIRT551431	hsa-miR-378g	PAR-CLIP	27292025
MIRT517917	hsa-miR-4437	PAR-CLIP	27292025
MIRT517917	hsa-miR-4437	PAR-CLIP	27292025
MIRT517913	hsa-miR-4674	PAR-CLIP	27292025
MIRT517913	hsa-miR-4674	PAR-CLIP	27292025
MIRT517921	hsa-miR-4740-3p	PAR-CLIP	27292025
MIRT517921	hsa-miR-4740-3p	PAR-CLIP	27292025
MIRT647951	hsa-miR-6500-3p	PAR-CLIP	27292025
MIRT551435	hsa-miR-660-3p	PAR-CLIP	27292025
MIRT551432	hsa-miR-6742-3p	PAR-CLIP	27292025
MIRT517914	hsa-miR-6749-3p	PAR-CLIP	27292025
MIRT517914	hsa-miR-6749-3p	PAR-CLIP	27292025
MIRT517919	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT517919	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT551429	hsa-miR-6783-3p	PAR-CLIP	27292025
MIRT551433	hsa-miR-6852-5p	PAR-CLIP	27292025
MIRT551434	hsa-miR-939-3p	PAR-CLIP	27292025
MIRT551434	hsa-miR-939-3p	PAR-CLIP	27292025
MIRT735392	hsa-miR-409-3p	qRT-PCR	32246041
MIRT551436	hsa-miR-1306-5p	HITS-CLIP	21572407
MIRT517922	hsa-miR-1224-3p	HITS-CLIP	21572407
MIRT517921	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT551435	hsa-miR-660-3p	HITS-CLIP	21572407
MIRT551434	hsa-miR-939-3p	HITS-CLIP	21572407
MIRT551433	hsa-miR-6852-5p	HITS-CLIP	21572407
MIRT551432	hsa-miR-6742-3p	HITS-CLIP	21572407
MIRT517920	hsa-miR-532-3p	HITS-CLIP	21572407
MIRT551431	hsa-miR-378g	HITS-CLIP	21572407
MIRT517919	hsa-miR-6778-3p	HITS-CLIP	21572407
MIRT517918	hsa-miR-423-3p	HITS-CLIP	21572407
MIRT517917	hsa-miR-4437	HITS-CLIP	21572407
MIRT517916	hsa-miR-1260a	HITS-CLIP	21572407
MIRT517915	hsa-miR-1260b	HITS-CLIP	21572407
MIRT517914	hsa-miR-6749-3p	HITS-CLIP	21572407
MIRT551430	hsa-miR-1343-3p	HITS-CLIP	21572407
MIRT551429	hsa-miR-6783-3p	HITS-CLIP	21572407
MIRT517913	hsa-miR-4674	HITS-CLIP	21572407
MIRT673592	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT672199	hsa-miR-3655	HITS-CLIP	23824327
MIRT673591	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT672198	hsa-miR-3135b	HITS-CLIP	23824327
MIRT672197	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT672196	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT672195	hsa-miR-3652	HITS-CLIP	23824327
MIRT672194	hsa-miR-4430	HITS-CLIP	23824327
MIRT673590	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT672192	hsa-miR-5698	HITS-CLIP	23824327
MIRT673593	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT673592	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT672199	hsa-miR-3655	HITS-CLIP	23824327
MIRT673591	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT672198	hsa-miR-3135b	HITS-CLIP	23824327
MIRT672197	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT672196	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT672195	hsa-miR-3652	HITS-CLIP	23824327
MIRT672194	hsa-miR-4430	HITS-CLIP	23824327
MIRT673590	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT672192	hsa-miR-5698	HITS-CLIP	23824327
MIRT672199	hsa-miR-3655	HITS-CLIP	23824327
MIRT672198	hsa-miR-3135b	HITS-CLIP	23824327
MIRT672197	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT672196	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT672195	hsa-miR-3652	HITS-CLIP	23824327
MIRT672194	hsa-miR-4430	HITS-CLIP	23824327
MIRT672193	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT672192	hsa-miR-5698	HITS-CLIP	23824327
MIRT647952	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT647950	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT647951	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT633778	hsa-miR-662	HITS-CLIP	23824327
MIRT633777	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT517920	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT633776	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633775	hsa-miR-1976	HITS-CLIP	23824327
MIRT517919	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT633774	hsa-miR-1206	HITS-CLIP	23824327
MIRT633773	hsa-miR-4279	HITS-CLIP	23824327
MIRT633772	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT551436	hsa-miR-1306-5p	PAR-CLIP	21572407
MIRT517922	hsa-miR-1224-3p	PAR-CLIP	21572407
MIRT517921	hsa-miR-4740-3p	PAR-CLIP	21572407
MIRT551435	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT551434	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT551433	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT551432	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT517920	hsa-miR-532-3p	PAR-CLIP	21572407
MIRT551431	hsa-miR-378g	PAR-CLIP	21572407
MIRT517919	hsa-miR-6778-3p	PAR-CLIP	21572407
MIRT517917	hsa-miR-4437	PAR-CLIP	21572407
MIRT517916	hsa-miR-1260a	PAR-CLIP	21572407
MIRT517915	hsa-miR-1260b	PAR-CLIP	21572407
MIRT517914	hsa-miR-6749-3p	PAR-CLIP	21572407
MIRT551430	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT551429	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT517913	hsa-miR-4674	PAR-CLIP	21572407
MIRT517922	hsa-miR-1224-3p	PAR-CLIP	23446348
MIRT517921	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT517920	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT517919	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT517918	hsa-miR-423-3p	PAR-CLIP	23446348
MIRT517917	hsa-miR-4437	PAR-CLIP	23446348
MIRT517916	hsa-miR-1260a	PAR-CLIP	23446348
MIRT517915	hsa-miR-1260b	PAR-CLIP	23446348
MIRT517914	hsa-miR-6749-3p	PAR-CLIP	23446348
MIRT517913	hsa-miR-4674	PAR-CLIP	23446348

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001530	Function	Lipopolysaccharide binding	IDA	20421939
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	7559487
GO:0004252	Function	Serine-type endopeptidase activity	IBA	21873635
GO:0004252	Function	Serine-type endopeptidase activity	IDA	1672265, 12855810
GO:0005102	Function	Signaling receptor binding	IPI	8626514, 12855810
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	3279057, 6323392, 8530382, 8626514, 14691232, 16230339, 16230340, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	9639571, 20421939
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0006953	Process	Acute-phase response	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IDA	1672265
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007275	Process	Multicellular organism development	TAS	9639571
GO:0007596	Process	Blood coagulation	TAS
GO:0007597	Process	Blood coagulation, intrinsic pathway	TAS
GO:0008047	Function	Enzyme activator activity	IEA
GO:0008083	Function	Growth factor activity	TAS	8626514
GO:0008201	Function	Heparin binding	IDA	20421939
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008360	Process	Regulation of cell shape	IEA
GO:0009611	Process	Response to wounding	IDA	9639571
GO:0009897	Component	External side of plasma membrane	IDA	20421939
GO:0010544	Process	Negative regulation of platelet activation	TAS	17379830
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	IEA
GO:0030168	Process	Platelet activation	IBA	21873635
GO:0030168	Process	Platelet activation	IDA	9038223
GO:0030168	Process	Platelet activation	TAS
GO:0030193	Process	Regulation of blood coagulation	TAS	12855810
GO:0030194	Process	Positive regulation of blood coagulation	IBA	21873635
GO:0030194	Process	Positive regulation of blood coagulation	IDA	9038223
GO:0030307	Process	Positive regulation of cell growth	IEA
GO:0030449	Process	Regulation of complement activation	TAS
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IDA	9639571
GO:0042730	Process	Fibrinolysis	IDA	12855810
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045861	Process	Negative regulation of proteolysis	IDA	1695900
GO:0046427	Process	Positive regulation of receptor signaling pathway via JAK-STAT	NAS	10692450
GO:0048712	Process	Negative regulation of astrocyte differentiation	IDA	1691280
GO:0050900	Process	Leukocyte migration	TAS
GO:0051281	Process	Positive regulation of release of sequestered calcium ion into cytosol	IDA	1672265, 19052258
GO:0051480	Process	Regulation of cytosolic calcium ion concentration	IDA	19052258
GO:0051838	Process	Cytolysis by host of symbiont cells	IDA	20421939
GO:0051918	Process	Negative regulation of fibrinolysis	TAS	17379830
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	20421939
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28327460
GO:0062023	Component	Collagen-containing extracellular matrix	IBA	21873635
GO:0070053	Function	Thrombospondin receptor activity	IDA	2435757
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070945	Process	Neutrophil-mediated killing of gram-negative bacterium	IDA	20421939
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:0090218	Process	Positive regulation of lipid kinase activity	IDA	11309392
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	20421939
GO:1900182	Process	Positive regulation of protein localization to nucleus	IDA	11309392
GO:1900738	Process	Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	20164183
GO:2000379	Process	Positive regulation of reactive oxygen species metabolic process	IDA	17275676

Other IDs

• MIM: 176930
• HGNC: 3535
• e!Ensembl: ENSG00000180210

Protein

• UniProt ID: P00734
• Protein name: Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
• Protein function: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates co
• PDB: 1A2C, 1A3B, 1A3E, 1A46, 1A4W, 1A5G, 1A61, 1ABI, 1ABJ, 1AD8, 1AE8, 1AFE, 1AHT, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00594	Gla	48 → 88	Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain	Domain
  PF00051	Kringle	108 → 186	Kringle domain	Domain
  PF00051	Kringle	213 → 291	Kringle domain	Domain
  PF09396	Thrombin_light	316 → 363	Thrombin light chain	Domain
  PF00089	Trypsin	364 → 613	Trypsin	Domain

• Sequence:

  MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
  VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
  NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
  CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
  QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
  DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
  DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
  DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
  VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
  RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
  GFYTHVFRLKKWIQKVIDQFGE

• Sequence length: 622

Pathways

KEGG:

Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Platelet activation
Regulation of actin cytoskeleton
Pathogenic Escherichia coli infection
Coronavirus disease - COVID-19
Pathways in cancer

Reactome:

Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
Platelet Aggregation (Plug Formation)
Regulation of Complement cascade

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	8333868
Anemia	Anemia	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505
Cerebral infarction	Cerebral Infarction	rs2230500
Liver failure	Liver Failure	rs118203990, rs118203991, rs118203992, rs387907022, rs201861847, rs796065037, rs759315662, rs368196005, rs796052121, rs369437593, rs367683258, rs766314948, rs368085185, rs770446752, rs753039116, rs776797592, rs1490906786, rs1562849964, rs759960319, rs776597537, rs375350359, rs1573008071, rs1601977105, rs1174791046, rs1019313682	18618250
Myocardial infarction	Myocardial Infarction	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	9531249, 9292507, 10027711
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	22841818
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	26001728
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	25821032, 28540026
Thrombophilia	Thrombophilia	rs118203912, rs118203911, rs121918141, rs121918142, rs121918143, rs121918144, rs121918145, rs121918146, rs121918147, rs121918148, rs121918149, rs121918151, rs121918152, rs121918153, rs121918154, rs1558715857, rs121918155, rs121918157, rs121918158, rs2104934553, rs121918159, rs121918160, rs121918477, rs121918473, rs121918474, rs267606981, rs2107137679, rs121918475, rs387906674, rs387907201, rs369504169, rs142742242, rs373983977, rs368074804, rs574132670, rs757583846, rs863224838, rs121918476, rs1333329860, rs1553424043, rs1553808038, rs5017717, rs374476971, rs1553809314, rs1553423955, rs767112991, rs1558718572, rs571278160, rs766261022, rs1321566264, rs1559926604, rs1241365457, rs759677822, rs1448630830, rs1305782685, rs1571577365, rs1247269491, rs777486993, rs201907715, rs769277939, rs199469503, rs1575904540, rs199469494, rs199469471, rs1189377845, rs1576182848, rs1688218776, rs1456533664, rs1709033502, rs1708668246, rs1708665916	16628723

Unknown
Disease name	Disease term	dbSNP ID	References
Blood coagulation disorders	Blood Coagulation Disorders		17721328
Brain infarction	Subcortical Infarction
Cerebral ischemia	Brain Ischemia		15534175, 14753426
Cerebral sinovenous thrombosis	Cerebral sinovenous thrombosis
Congenital factor ii deficiency	Congenital factor II deficiency
Development disorder	Child Development Disorders, Pervasive		28540026
Disseminated intravascular coagulation	Disseminated Intravascular Coagulation		1894189
Factor ii deficiency	Factor II deficiency		25242243, 23852823
Fatty liver	Fatty Liver, Steatohepatitis		20008134
Hereditary factor ii deficiency disease	Hereditary factor II deficiency disease		23852823, 25242243
Hypoprothrombinemia	Hypoprothrombinemias		7740448, 3567158
Inherited factor ii deficiency	Inherited Factor II deficiency		3771562, 3567158, 9569177, 3242619, 1421398, 25242243, 6405779, 1349838, 3801671, 14962227, 7792730, 23852823, 7865694, 2719946, 19289024, 1354985
Intracranial sinus thrombophlebitis	Intracranial Sinus Thrombophlebitis		12269725
Ischemic stroke	Ischemic stroke	rs6025, rs1799963, rs1799983	26908601
Liver carcinoma	Liver carcinoma		2821104
Liver cirrhosis	Liver Cirrhosis		10216089
Liver fibrosis	Fibrosis, Liver		10216089
Mesenteric arterial embolus	Acute Mesenteric Arterial Embolus		24282370
Mesenteric arterial thrombosis	Acute Mesenteric Arterial Thrombosis		24282370
Mesenteric vascular insufficiency	Mesenteric vascular insufficiency		24282370
Nephrosis	Nephrosis		18541230
Non rare thrombophilia	NON RARE IN EUROPE: Non rare thrombophilia
Non-alcoholic fatty liver disease	Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis		22841818
Nonocclusive mesenteric ischemia	Nonocclusive Mesenteric Ischemia		24282370
Occlusive mesenteric arterial ischemia	Occlusive Mesenteric Arterial Ischemia		24282370
Paratuberculosis	Paratuberculosis		22633222
Petrous sinus thrombophlebitis	Petrous Sinus Thrombophlebitis		12269725
Petrous sinus thrombosis	Petrous Sinus Thrombosis		12269725
Senile dementia	Presenile dementia, Acute Confusional Senile Dementia		8333868
Sinus thrombosis, intracranial	Sinus Thrombosis, Intracranial		12269725
Skin diseases, vascular	Skin Diseases, Vascular		17535202
Stroke	Cerebrovascular accident, Acute Cerebrovascular Accidents		15059842, 26908601, 27031503, 19652888, 11443298, 15534175, 15534175
Thrombosis	Deep Vein Thrombosis, Thrombosis of cerebral veins		19920886, 9869612, 12296757, 26908601