Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
2107 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Eukaryotic translation termination factor 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
ETF1 |
SynonymsGene synonyms aliases
|
D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1 |
ChromosomeChromosome number
|
5 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
5q31.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which prom |
miRNAmiRNA information provided by mirtarbase database.
|
|
Transcription factors
|
Transcription factor |
Regulation |
Reference |
SP3 |
Repression |
14563555 |
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000184 |
Process |
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS |
|
GO:0002184 |
Process |
Cytoplasmic translational termination |
IBA |
21873635 |
GO:0003723 |
Function |
RNA binding |
HDA |
22658674 |
GO:0003747 |
Function |
Translation release factor activity |
IDA |
7990965 |
GO:0003747 |
Function |
Translation release factor activity |
TAS |
15326224 |
GO:0005515 |
Function |
Protein binding |
IPI |
9620853, 9712840, 16189514, 18256688, 18447585, 19615732, 23091004, 24486019, 25416956, 28514442, 32296183 |
GO:0005634 |
Component |
Nucleus |
IDA |
12426392 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
12426392, 24486019 |
GO:0005829 |
Component |
Cytosol |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006415 |
Process |
Translational termination |
IDA |
7990965 |
GO:0006449 |
Process |
Regulation of translational termination |
IMP |
30682371 |
GO:0006479 |
Process |
Protein methylation |
IDA |
18539146 |
GO:0008079 |
Function |
Translation termination factor activity |
IMP |
24486019 |
GO:0016149 |
Function |
Translation release factor activity, codon specific |
IBA |
21873635 |
GO:0018444 |
Component |
Translation release factor complex |
IBA |
21873635 |
GO:0043022 |
Function |
Ribosome binding |
TAS |
12867083 |
GO:1990825 |
Function |
Sequence-specific mRNA binding |
IBA |
21873635 |
GO:1990825 |
Function |
Sequence-specific mRNA binding |
IMP |
12909007 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P62495 |
Protein name |
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) |
Protein function |
Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793, |
PDB |
1DT9
,
2HST
,
2KTU
,
2KTV
,
2LGT
,
2LLX
,
2MQ6
,
2MQ9
,
3E1Y
,
3J5Y
,
3JAG
,
3JAH
,
3JAI
,
4D5N
,
4D61
,
5A8L
,
5LZT
,
5LZU
,
5LZV
,
6D90
,
6IP8
,
6XA1
,
6ZME
,
8SCB
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF03463 |
eRF1_1 |
18 → 140 |
eRF1 domain 1 |
Domain |
PF03464 |
eRF1_2 |
145 → 277 |
eRF1 domain 2 |
Domain |
PF03465 |
eRF1_3 |
280 → 417 |
eRF1 domain 3 |
Domain |
|
Sequence |
|
Sequence length |
437 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
31268507, 25056061, 26198764, 28540026, 29483656, 30285260 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Development disorder |
Child Development Disorders, Pervasive |
|
28540026 |
|