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ETF1 (eukaryotic translation termination factor 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2107
Gene nameGene Name - the full gene name approved by the HGNC.
Eukaryotic translation termination factor 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ETF1
SynonymsGene synonyms aliases
D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which prom
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT046100 hsa-miR-125b-5p CLASH 23622248
MIRT045869 hsa-miR-128-3p CLASH 23622248
MIRT042497 hsa-miR-423-3p CLASH 23622248
MIRT628249 hsa-miR-1306-5p HITS-CLIP 23824327
MIRT628248 hsa-miR-6832-3p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
SP3 Repression 14563555
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0002184 Process Cytoplasmic translational termination IBA 21873635
GO:0003723 Function RNA binding HDA 22658674
GO:0003747 Function Translation release factor activity IDA 7990965
GO:0003747 Function Translation release factor activity TAS 15326224
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P62495
Protein name Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)
Protein function Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:10676813, PubMed:16777602, PubMed:24486019, PubMed:26245381, PubMed:27863242, PubMed:36638793,
PDB 1DT9 , 2HST , 2KTU , 2KTV , 2LGT , 2LLX , 2MQ6 , 2MQ9 , 3E1Y , 3J5Y , 3JAG , 3JAH , 3JAI , 4D5N , 4D61 , 5A8L , 5LZT , 5LZU , 5LZV , 6D90 , 6IP8 , 6XA1 , 6ZME , 8SCB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03463 eRF1_1
18 140
eRF1 domain 1
Domain
PF03464 eRF1_2
145 277
eRF1 domain 2
Domain
PF03465 eRF1_3
280 417
eRF1 domain 3
Domain
Sequence
Sequence length 437
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  mRNA surveillance pathway   Eukaryotic Translation Termination
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 31268507, 25056061, 26198764, 28540026, 29483656, 30285260
Unknown
Disease name Disease term dbSNP ID References
Development disorder Child Development Disorders, Pervasive 28540026

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