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ERG (ETS transcription factor ERG)

Gene

2078

ETS transcription factor ERG

ERG

LMPHM14, erg-3, p55

21q22.2

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apo

Show/Hide all(135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT007094	hsa-miR-145-5p	Luciferase reporter assay	23480797
MIRT016692	hsa-miR-133b	Reporter assay	17344217
MIRT053340	hsa-miR-30a-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23728339
MIRT053340	hsa-miR-30a-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23728339
MIRT053341	hsa-miR-30b-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23728339
MIRT053341	hsa-miR-30b-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23728339
MIRT007094	hsa-miR-145-5p	Luciferase reporter assay, qRT-PCR, Western blot	27572146
MIRT734449	hsa-miR-223-5p	Luciferase reporter assay, qRT-PCR, Western blotting	32489464
MIRT736886	hsa-miR-362-3p	Luciferase reporter assay, qRT-PCR	31659098
MIRT737355	hsa-miR-200b-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR	32591615
MIRT968746	hsa-miR-105	CLIP-seq
MIRT968747	hsa-miR-106a	CLIP-seq
MIRT968748	hsa-miR-106b	CLIP-seq
MIRT968749	hsa-miR-130a	CLIP-seq
MIRT968750	hsa-miR-130b	CLIP-seq
MIRT968751	hsa-miR-136	CLIP-seq
MIRT968752	hsa-miR-141	CLIP-seq
MIRT968753	hsa-miR-17	CLIP-seq
MIRT968754	hsa-miR-19a	CLIP-seq
MIRT968755	hsa-miR-19b	CLIP-seq
MIRT968756	hsa-miR-200a	CLIP-seq
MIRT968757	hsa-miR-20a	CLIP-seq
MIRT968758	hsa-miR-20b	CLIP-seq
MIRT968759	hsa-miR-217	CLIP-seq
MIRT968760	hsa-miR-301a	CLIP-seq
MIRT968761	hsa-miR-301b	CLIP-seq
MIRT968762	hsa-miR-3166	CLIP-seq
MIRT968763	hsa-miR-3657	CLIP-seq
MIRT968764	hsa-miR-3666	CLIP-seq
MIRT968765	hsa-miR-4279	CLIP-seq
MIRT968766	hsa-miR-4295	CLIP-seq
MIRT968767	hsa-miR-4307	CLIP-seq
MIRT968768	hsa-miR-4503	CLIP-seq
MIRT968769	hsa-miR-454	CLIP-seq
MIRT968770	hsa-miR-4669	CLIP-seq
MIRT968771	hsa-miR-4771	CLIP-seq
MIRT968772	hsa-miR-486-5p	CLIP-seq
MIRT968773	hsa-miR-515-5p	CLIP-seq
MIRT968774	hsa-miR-519a	CLIP-seq
MIRT968775	hsa-miR-519b-3p	CLIP-seq
MIRT968776	hsa-miR-519c-3p	CLIP-seq
MIRT968777	hsa-miR-519d	CLIP-seq
MIRT968778	hsa-miR-548t	CLIP-seq
MIRT968779	hsa-miR-568	CLIP-seq
MIRT968780	hsa-miR-629	CLIP-seq
MIRT968781	hsa-miR-885-5p	CLIP-seq
MIRT968782	hsa-miR-891b	CLIP-seq
MIRT968783	hsa-miR-93	CLIP-seq
MIRT968784	hsa-miR-137	CLIP-seq
MIRT968785	hsa-miR-1237	CLIP-seq
MIRT968786	hsa-miR-1248	CLIP-seq
MIRT968787	hsa-miR-1253	CLIP-seq
MIRT968788	hsa-miR-1256	CLIP-seq
MIRT968789	hsa-miR-1258	CLIP-seq
MIRT968790	hsa-miR-1273e	CLIP-seq
MIRT968791	hsa-miR-1279	CLIP-seq
MIRT968752	hsa-miR-141	CLIP-seq
MIRT968792	hsa-miR-1915	CLIP-seq
MIRT968756	hsa-miR-200a	CLIP-seq
MIRT968759	hsa-miR-217	CLIP-seq
MIRT968793	hsa-miR-30a	CLIP-seq
MIRT968794	hsa-miR-30b	CLIP-seq
MIRT968795	hsa-miR-30c	CLIP-seq
MIRT968796	hsa-miR-30d	CLIP-seq
MIRT968797	hsa-miR-30e	CLIP-seq
MIRT968798	hsa-miR-3124-3p	CLIP-seq
MIRT968799	hsa-miR-3129-3p	CLIP-seq
MIRT968800	hsa-miR-340	CLIP-seq
MIRT968801	hsa-miR-3662	CLIP-seq
MIRT968802	hsa-miR-3663-5p	CLIP-seq
MIRT968803	hsa-miR-3978	CLIP-seq
MIRT968804	hsa-miR-4261	CLIP-seq
MIRT968765	hsa-miR-4279	CLIP-seq
MIRT968805	hsa-miR-4297	CLIP-seq
MIRT968806	hsa-miR-4317	CLIP-seq
MIRT968807	hsa-miR-4424	CLIP-seq
MIRT968768	hsa-miR-4503	CLIP-seq
MIRT968808	hsa-miR-4511	CLIP-seq
MIRT968809	hsa-miR-4528	CLIP-seq
MIRT968810	hsa-miR-4698	CLIP-seq
MIRT968811	hsa-miR-4726-3p	CLIP-seq
MIRT968812	hsa-miR-4797-5p	CLIP-seq
MIRT968813	hsa-miR-548b-3p	CLIP-seq
MIRT968814	hsa-miR-553	CLIP-seq
MIRT968815	hsa-miR-567	CLIP-seq
MIRT968816	hsa-miR-571	CLIP-seq
MIRT968817	hsa-miR-580	CLIP-seq
MIRT968780	hsa-miR-629	CLIP-seq
MIRT968818	hsa-miR-1200	CLIP-seq
MIRT968790	hsa-miR-1273e	CLIP-seq
MIRT968751	hsa-miR-136	CLIP-seq
MIRT968819	hsa-miR-4289	CLIP-seq
MIRT968806	hsa-miR-4317	CLIP-seq
MIRT968820	hsa-miR-4324	CLIP-seq
MIRT968821	hsa-miR-4672	CLIP-seq
MIRT968822	hsa-miR-544b	CLIP-seq
MIRT968792	hsa-miR-1915	CLIP-seq
MIRT1987127	hsa-miR-3130-3p	CLIP-seq
MIRT1987128	hsa-miR-3607-3p	CLIP-seq
MIRT968801	hsa-miR-3662	CLIP-seq
MIRT1987129	hsa-miR-3686	CLIP-seq
MIRT1987130	hsa-miR-370	CLIP-seq
MIRT968803	hsa-miR-3978	CLIP-seq
MIRT968805	hsa-miR-4297	CLIP-seq
MIRT1987131	hsa-miR-4652-3p	CLIP-seq
MIRT968810	hsa-miR-4698	CLIP-seq
MIRT968811	hsa-miR-4726-3p	CLIP-seq
MIRT1987132	hsa-miR-4776-3p	CLIP-seq
MIRT968816	hsa-miR-571	CLIP-seq
MIRT1987133	hsa-miR-626	CLIP-seq
MIRT968747	hsa-miR-106a	CLIP-seq
MIRT968748	hsa-miR-106b	CLIP-seq
MIRT968785	hsa-miR-1237	CLIP-seq
MIRT968786	hsa-miR-1248	CLIP-seq
MIRT968753	hsa-miR-17	CLIP-seq
MIRT968757	hsa-miR-20a	CLIP-seq
MIRT968758	hsa-miR-20b	CLIP-seq
MIRT2221526	hsa-miR-3137	CLIP-seq
MIRT2221527	hsa-miR-3182	CLIP-seq
MIRT1987128	hsa-miR-3607-3p	CLIP-seq
MIRT2221528	hsa-miR-3609	CLIP-seq
MIRT1987129	hsa-miR-3686	CLIP-seq
MIRT2221529	hsa-miR-4432	CLIP-seq
MIRT1987131	hsa-miR-4652-3p	CLIP-seq
MIRT2221530	hsa-miR-4780	CLIP-seq
MIRT2221531	hsa-miR-4796-3p	CLIP-seq
MIRT2221532	hsa-miR-499-5p	CLIP-seq
MIRT968777	hsa-miR-519d	CLIP-seq
MIRT2221533	hsa-miR-539	CLIP-seq
MIRT2221534	hsa-miR-548ah	CLIP-seq
MIRT2221535	hsa-miR-615-5p	CLIP-seq
MIRT2221536	hsa-miR-623	CLIP-seq
MIRT2221537	hsa-miR-758	CLIP-seq
MIRT2221538	hsa-miR-764	CLIP-seq
MIRT968783	hsa-miR-93	CLIP-seq

Transcription factors

Show/Hide all(8)

Transcription factor	Regulation	Reference
ERG	Activation	21536859
ETS1	Activation	7731694
ETS2	Activation	7731694
FLI1	Activation	21536859
GATA3	Activation	21536859
LMO2	Activation	21536859
LYL1	Activation	21536859
TAL1	Activation	21536859

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	23093599
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	18195090
GO:0003677	Function	DNA binding	TAS	8502479
GO:0003682	Function	Chromatin binding	IEA
GO:0005515	Function	Protein binding	IPI	20478527, 21575865, 22531786, 22722839, 27109047
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006468	Process	Protein phosphorylation	TAS	8502479
GO:0007165	Process	Signal transduction	TAS	8502479
GO:0007275	Process	Multicellular organism development	TAS	8502479
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	18195090, 23913826
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	18195090, 22235125
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661

MIM	HGNC	e!Ensembl
165080	3446	ENSG00000157554

Protein

UniProt ID

P11308

Protein name

Transcriptional regulator ERG (Transforming protein ERG)

Protein function

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

PDB

1SXE , 4IRG , 4IRH , 4IRI , 5YBC , 5YBD , 6VGE , 6VGG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02198	SAM_PNT	122 → 205	Sterile alpha motif (SAM)/Pointed domain	Domain
PF00178	Ets	319 → 398	Ets-domain	Domain

Sequence

MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQP
PARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTT
NERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLT
PSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA
TQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTS
SRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNM
NYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGS
YHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY

Sequence length

479

Interactions

View interactions

	KEGG
	Transcriptional misregulation in cancer Prostate cancer

Associated diseases

Show/Hide Causal Diseases (6)

Causal
Disease name	Disease term	dbSNP ID	References
Aortic aneurysm	Aortic Aneurysm, Abdominal	rs1555554098, rs267606902, rs121434526, rs121434527, rs121434528, rs387906592, rs387906781, rs387906782, rs397516685, rs397514037, rs112901682, rs397515325, rs397515330, rs794728025, rs112602953, rs794728021, rs8046180, rs797045725, rs876657852, rs878854466, rs886038978, rs746972765, rs886039303, rs886040965, rs886040966, rs886040967, rs886229659, rs1553781304, rs1060502531, rs1553795301, rs1553803235, rs1213452826, rs869025352, rs1553780501, rs1553785222, rs1382893400, rs1554841990, rs1430822242, rs1567692384, rs1576422965, rs1596712899, rs2059732940, rs2041090817, rs1439991530	27899403
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	22843504
Leukemia	leukemia, Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	19108891, 19822134
Lymphoblastic leukemia	Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	27776115
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	27386562
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	19396168, 25735316, 27783944, 28783165, 18798265, 17173048, 27223260

Show/Hide Unknown Diseases (8)

Unknown
Disease name	Disease term	dbSNP ID	References
Ewing sarcoma	Ewings sarcoma
Extra-osseous ewing`s sarcoma	Extra-osseous Ewing`s sarcoma		11823984
Extraskeletal ewing sarcoma	Extraskeletal Ewing sarcoma
Knee osteoarthritis	Osteoarthritis, Knee		30664745
Myeloid leukemia	Acute Myeloid Leukemia, M1		19822134
Osteoarthritis of hip	Osteoarthritis of hip		30664745
Prostatic neoplasms	Prostatic Neoplasms		25735316, 17173048, 19396168, 27223260, 18798265, 27783944, 28783165
Skeletal ewing sarcoma	Skeletal Ewing sarcoma

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