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EPHB3 (EPH receptor B3)

Gene

EPH receptor B3

EPHB3

EK2, ETK2, HEK2, TYRO6

3

3q27.1

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to

Show/Hide all(190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT542122	hsa-miR-8485	HITS-CLIP	19536157
MIRT542121	hsa-miR-603	HITS-CLIP	19536157
MIRT542120	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT542119	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT542121	hsa-miR-603	HITS-CLIP	19536157
MIRT542120	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT626271	hsa-miR-518c-5p	HITS-CLIP	19536157
MIRT626270	hsa-miR-326	HITS-CLIP	19536157
MIRT626269	hsa-miR-330-5p	HITS-CLIP	19536157
MIRT626268	hsa-miR-6764-3p	HITS-CLIP	19536157
MIRT626267	hsa-miR-6824-3p	HITS-CLIP	19536157
MIRT542119	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT626266	hsa-miR-3191-5p	HITS-CLIP	19536157
MIRT542122	hsa-miR-8485	HITS-CLIP	21572407
MIRT542121	hsa-miR-603	HITS-CLIP	21572407
MIRT542120	hsa-miR-342-3p	HITS-CLIP	21572407
MIRT542119	hsa-miR-377-3p	HITS-CLIP	21572407
MIRT542122	hsa-miR-8485	HITS-CLIP	23313552
MIRT542121	hsa-miR-603	HITS-CLIP	23313552
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT626271	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT626270	hsa-miR-326	HITS-CLIP	23824327
MIRT626269	hsa-miR-330-5p	HITS-CLIP	23824327
MIRT626268	hsa-miR-6764-3p	HITS-CLIP	23824327
MIRT626267	hsa-miR-6824-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT626266	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT626271	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT626270	hsa-miR-326	HITS-CLIP	23824327
MIRT626269	hsa-miR-330-5p	HITS-CLIP	23824327
MIRT626268	hsa-miR-6764-3p	HITS-CLIP	23824327
MIRT626267	hsa-miR-6824-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT626266	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT626271	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT626270	hsa-miR-326	HITS-CLIP	23824327
MIRT626269	hsa-miR-330-5p	HITS-CLIP	23824327
MIRT626268	hsa-miR-6764-3p	HITS-CLIP	23824327
MIRT626267	hsa-miR-6824-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT626266	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	PAR-CLIP	21572407
MIRT542121	hsa-miR-603	PAR-CLIP	21572407
MIRT542120	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT542119	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT542120	hsa-miR-342-3p	HITS-CLIP	27418678
MIRT542119	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT542121	hsa-miR-603	HITS-CLIP	27418678
MIRT542122	hsa-miR-8485	HITS-CLIP	19536157
MIRT542121	hsa-miR-603	HITS-CLIP	19536157
MIRT542120	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT542119	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT542121	hsa-miR-603	HITS-CLIP	19536157
MIRT542120	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT626271	hsa-miR-518c-5p	HITS-CLIP	19536157
MIRT626270	hsa-miR-326	HITS-CLIP	19536157
MIRT626269	hsa-miR-330-5p	HITS-CLIP	19536157
MIRT626268	hsa-miR-6764-3p	HITS-CLIP	19536157
MIRT626267	hsa-miR-6824-3p	HITS-CLIP	19536157
MIRT542119	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT626266	hsa-miR-3191-5p	HITS-CLIP	19536157
MIRT542122	hsa-miR-8485	HITS-CLIP	21572407
MIRT542121	hsa-miR-603	HITS-CLIP	21572407
MIRT542120	hsa-miR-342-3p	HITS-CLIP	21572407
MIRT542119	hsa-miR-377-3p	HITS-CLIP	21572407
MIRT542122	hsa-miR-8485	HITS-CLIP	23313552
MIRT542121	hsa-miR-603	HITS-CLIP	23313552
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23313552
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23313552
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT626271	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT626270	hsa-miR-326	HITS-CLIP	23824327
MIRT626269	hsa-miR-330-5p	HITS-CLIP	23824327
MIRT626268	hsa-miR-6764-3p	HITS-CLIP	23824327
MIRT626267	hsa-miR-6824-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT626266	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT626271	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT626270	hsa-miR-326	HITS-CLIP	23824327
MIRT626269	hsa-miR-330-5p	HITS-CLIP	23824327
MIRT626268	hsa-miR-6764-3p	HITS-CLIP	23824327
MIRT626267	hsa-miR-6824-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT626266	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT626271	hsa-miR-518c-5p	HITS-CLIP	23824327
MIRT626270	hsa-miR-326	HITS-CLIP	23824327
MIRT626269	hsa-miR-330-5p	HITS-CLIP	23824327
MIRT626268	hsa-miR-6764-3p	HITS-CLIP	23824327
MIRT626267	hsa-miR-6824-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT626266	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT542121	hsa-miR-603	HITS-CLIP	23824327
MIRT542120	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT542119	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542122	hsa-miR-8485	PAR-CLIP	21572407
MIRT542121	hsa-miR-603	PAR-CLIP	21572407
MIRT542120	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT542119	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT966703	hsa-miR-1254	CLIP-seq
MIRT966704	hsa-miR-137	CLIP-seq
MIRT966705	hsa-miR-1825	CLIP-seq
MIRT966706	hsa-miR-1972	CLIP-seq
MIRT966707	hsa-miR-3116	CLIP-seq
MIRT966708	hsa-miR-3177-3p	CLIP-seq
MIRT966709	hsa-miR-324-5p	CLIP-seq
MIRT966710	hsa-miR-377	CLIP-seq
MIRT966711	hsa-miR-4254	CLIP-seq
MIRT966712	hsa-miR-4434	CLIP-seq
MIRT966713	hsa-miR-4516	CLIP-seq
MIRT966714	hsa-miR-4531	CLIP-seq
MIRT966715	hsa-miR-4642	CLIP-seq
MIRT966716	hsa-miR-4650-5p	CLIP-seq
MIRT966717	hsa-miR-4778-5p	CLIP-seq
MIRT966718	hsa-miR-626	CLIP-seq
MIRT1548390	hsa-miR-4722-3p	CLIP-seq
MIRT1548391	hsa-miR-4755-3p	CLIP-seq
MIRT966710	hsa-miR-377	CLIP-seq
MIRT966710	hsa-miR-377	CLIP-seq
MIRT2220914	hsa-miR-1193	CLIP-seq
MIRT2220915	hsa-miR-1343	CLIP-seq
MIRT2220916	hsa-miR-149	CLIP-seq
MIRT2220917	hsa-miR-1914	CLIP-seq
MIRT2220918	hsa-miR-19a	CLIP-seq
MIRT2220919	hsa-miR-19b	CLIP-seq
MIRT2220920	hsa-miR-2392	CLIP-seq
MIRT2220921	hsa-miR-23a	CLIP-seq
MIRT2220922	hsa-miR-23b	CLIP-seq
MIRT2220923	hsa-miR-23c	CLIP-seq
MIRT2220924	hsa-miR-3064-5p	CLIP-seq
MIRT2220925	hsa-miR-320e	CLIP-seq
MIRT2220926	hsa-miR-323-5p	CLIP-seq
MIRT2220927	hsa-miR-339-5p	CLIP-seq
MIRT2220928	hsa-miR-3689d	CLIP-seq
MIRT966710	hsa-miR-377	CLIP-seq
MIRT2220929	hsa-miR-3921	CLIP-seq
MIRT2220930	hsa-miR-4251	CLIP-seq
MIRT2220931	hsa-miR-4329	CLIP-seq
MIRT966712	hsa-miR-4434	CLIP-seq
MIRT966713	hsa-miR-4516	CLIP-seq
MIRT2220932	hsa-miR-4653-5p	CLIP-seq
MIRT2220933	hsa-miR-4794	CLIP-seq
MIRT2220934	hsa-miR-491-5p	CLIP-seq
MIRT2220935	hsa-miR-597	CLIP-seq
MIRT2220936	hsa-miR-605	CLIP-seq
MIRT2220937	hsa-miR-760	CLIP-seq
MIRT2220938	hsa-miR-876-3p	CLIP-seq
MIRT966710	hsa-miR-377	CLIP-seq

Show/Hide all(40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	ISS
GO:0001655	Process	Urogenital system development	ISS
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IBA	21873635
GO:0005003	Function	Ephrin receptor activity	IDA	8397371, 15536074
GO:0005005	Function	Transmembrane-ephrin receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	8397371, 15536074
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0007275	Process	Multicellular organism development	IBA	21873635
GO:0007411	Process	Axon guidance	IBA	21873635
GO:0007411	Process	Axon guidance	ISS
GO:0007413	Process	Axonal fasciculation	ISS
GO:0008046	Function	Axon guidance receptor activity	IEA
GO:0016477	Process	Cell migration	IDA	15536074
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0021952	Process	Central nervous system projection neuron axonogenesis	IEA
GO:0022038	Process	Corpus callosum development	ISS
GO:0022407	Process	Regulation of cell-cell adhesion	IDA	8397371
GO:0030425	Component	Dendrite	IEA
GO:0031290	Process	Retinal ganglion cell axon guidance	IEA
GO:0033674	Process	Positive regulation of kinase activity	IBA	21873635
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IDA	15536074
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043087	Process	Regulation of GTPase activity	IDA	15536074
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0046777	Process	Protein autophosphorylation	IDA	8397371, 15536074
GO:0048013	Process	Ephrin receptor signaling pathway	IDA	8397371, 15536074
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0048538	Process	Thymus development	ISS
GO:0048546	Process	Digestive tract morphogenesis	ISS
GO:0050770	Process	Regulation of axonogenesis	ISS
GO:0051965	Process	Positive regulation of synapse assembly	ISS
GO:0060021	Process	Roof of mouth development	ISS
GO:0060996	Process	Dendritic spine development	ISS
GO:0060997	Process	Dendritic spine morphogenesis	ISS

MIM	HGNC	e!Ensembl
601839	3394	ENSG00000182580

Protein

UniProt ID

Protein name

Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)

Protein function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is

PDB

3P1I , 3ZFY , 5L6O , 5L6P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01404	Ephrin_lbd	40 → 212	Ephrin receptor ligand binding domain	Domain
PF07699	Ephrin_rec_like	277 → 320	Putative ephrin-receptor like	Family
PF00041	fn3	341 → 437	Fibronectin type III domain	Domain
PF00041	fn3	454 → 535	Fibronectin type III domain	Domain
PF14575	EphA2_TM	560 → 630	Ephrin type-A receptor 2 transmembrane domain	Domain
PF07714	PK_Tyr_Ser-Thr	633 → 892	Protein tyrosine and serine/threonine kinase	Domain
PF00536	SAM_1	923 → 987	SAM domain (Sterile alpha motif)	Domain

Sequence

MARARPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMDTKWVTSELAWTSHPES
GWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIP
NIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKVRS
FGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGT
CIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPCPPGSYKAKQGEGP
CLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNETSLILEWS
EPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTR
YTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPN
GVILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEF
ETTSERGSGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQY
IAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREV
FVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALD
SFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLS
RFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYW
DMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAA
SLKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQM
TAEDLLRIGVTLAGHQKKILSSIQDMRLQMNQTLPVQV

Sequence length

998

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		EPH-Ephrin signaling EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193

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